Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Kimberly D, Siegmund"'
Autor:
Talar S. Habeshian, Kimberly L. Cannavale, Jeff M. Slezak, Yu-Hsiang Shu, Gary W. Chien, XuFeng Chen, Feng Shi, Kimberly D. Siegmund, Stephen K. Van Den Eeden, Jiaoti Huang, Chun R. Chao
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTAccurately identifying life-threatening prostate cancer (PCa) at time of diagnosis remains an unsolved problem. We evaluated whether DNA methylation status of selected candidate genes can predict the risk of metastasis beyond clinical risk fa
Externí odkaz:
https://doaj.org/article/e9339ab4917847d98550c4fbbffd952c
Autor:
Eric M. Nickels, Shaobo Li, Swe Swe Myint, Katti Arroyo, Qianxi Feng, Kimberly D. Siegmund, Adam J. de Smith, Joseph L. Wiemels
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The role of DNA methylation in predisposing to pediatric acute lymphoblastic leukemia remains unknown. Here, the authors utilize a discordant twin model to investigate how DNA methylation variation contributes to disease risk in genetically identical
Externí odkaz:
https://doaj.org/article/3889c1c5cc274b629ea0d875b109d181
Autor:
Stella Tommasi, Niccolo Pabustan, Meng Li, Yibu Chen, Kimberly D. Siegmund, Ahmad Besaratinia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract We constructed and analyzed the whole transcriptome in leukocytes of healthy adult vapers (with/without a history of smoking), ‘exclusive’ cigarette smokers, and controls (non-users of any tobacco products). Furthermore, we performed sin
Externí odkaz:
https://doaj.org/article/dd72f671dbf64e5bb3287a2fd5e0e489
Autor:
Ivo S. Muskens, Shaobo Li, Thomas Jackson, Natalina Elliot, Helen M. Hansen, Swe Swe Myint, Priyatama Pandey, Jeremy M. Schraw, Ritu Roy, Joaquin Anguiano, Katerina Goudevenou, Kimberly D. Siegmund, Philip J. Lupo, Marella F. T. R. de Bruijn, Kyle M. Walsh, Paresh Vyas, Xiaomei Ma, Anindita Roy, Irene Roberts, Joseph L. Wiemels, Adam J. de Smith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Down syndrome has a high co-morbidity with immune and hematopoietic disorders. Here, the authors perform an epigenome-wide association study in newborns with and without Down syndrome to find differential methylation across the genome, including in h
Externí odkaz:
https://doaj.org/article/638c652373704f3aa4579682f8dc481e
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objective Recently, many tumor sequencing studies have inferred and reported on mutational signatures, short nucleotide patterns at which particular somatic base substitutions appear more often. A number of signatures reflect biological proc
Externí odkaz:
https://doaj.org/article/b4d48ad1e6094fd8a62374f221d9851f
Autor:
Kathryn L. Mills, Kimberly D. Siegmund, Christian K. Tamnes, Lia Ferschmann, Lara M. Wierenga, Marieke G.N. Bos, Beatriz Luna, Chun Li, Megan M. Herting
Publikováno v:
NeuroImage, Vol 242, Iss , Pp 118450- (2021)
A fundamental task in neuroscience is to characterize the brain's developmental course. While replicable group-level models of structural brain development from childhood to adulthood have recently been identified, we have yet to quantify and underst
Externí odkaz:
https://doaj.org/article/0a0cae17bc7d4512a356ef451010eac0
Publikováno v:
Epigenetics, Vol 13, Iss 10-11, Pp 1027-1038 (2018)
AXL is one of the TAM (TYRO3, AXL and MERTK) receptor tyrosine kinases and may be involved in airway inflammation. Little is known about how epigenetic changes in AXL may affect lung development during adolescence. We investigated the association bet
Externí odkaz:
https://doaj.org/article/32dddf9248364388b4a933e7edd033d8
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)
Abstract Background To integrate molecular features from multiple high-throughput platforms in prediction, a regression model that penalizes features from all platforms equally is commonly used. However, data from different platforms are likely to di
Externí odkaz:
https://doaj.org/article/b23a285ad1b54a30b6208477ddc37f78
Autor:
Zhijie Xu, Hemant Gujar, Guanghou Fu, Hamed Ahmadi, Sumeet Bhanvadia, Daniel J. Weisenberger, Baiye Jin, Parkash S. Gill, Inderbir Gill, Siamak Daneshmand, Kimberly D. Siegmund, Gangning Liang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundMuscle-invasive bladder cancer (MIBC) accounts for approximately 20% of all urothelial bladder carcinomas (UBC) at time of diagnosis, and up to 30% of patients with non-muscle invasive UBC will progress to MIBC over time. An increasing body
Externí odkaz:
https://doaj.org/article/3716e0941f1e4cf7a057fd87bd25d42d
Publikováno v:
F1000Research, Vol 9 (2020)
There are two frameworks for characterizing mutational signatures which are commonly used to describe the nucleotide patterns that arise from mutational processes. Estimated mutational signatures from fitting these two methods in human cancer can be
Externí odkaz:
https://doaj.org/article/9bc4567e4a044e7bbb1f89fa6e21da05