Výsledky vyhledávání - "Kimberly Cruz"

Activation of Pyruvate Kinase-R with Etavopivat (FT-4202) Is Well Tolerated, Improves Anemia, and Decreases Intravascular Hemolysis in Patients with Sickle Cell Disease Treated for up to 12 Weeks

Autor: Santosh L. Saraf, Patrick Kelly, Theodosia A. Kalfa, Marilyn J. Telen, Modupe Idowu, Patricia Schroeder, James Geib, Kimberly Cruz, R. Clark Brown, Sanjeev Forsyth, Eric Q. Wu

Publikováno v: Blood. 138:9-9

Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR), that increases PKR activity, resulting in decreased 2,3-DPG and increased ATP in red blood cells (RBCs) of healthy volunteers (HV) and patients (pts) with sickle cell dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0fce9c947e441ecfe5e8d335ccf9156
https://doi.org/10.1182/blood-2021-147091

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Binding of Hg by bacterial extracellular polysaccharide: a possible role in Hg tolerance

Autor: Tamar Barkay, Jean Guezennec, Kimberly Cruz

Publikováno v: Applied Microbiology And Biotechnology (0175-7598) (Springer), 2017-07, Vol. 101, N. 13, P. 5493-5503

Bacteria employ adaptive mechanisms of mercury (Hg) tolerance to survive in environments containing elevated Hg concentrations. The potential of extracellular polysaccharides (EPS) production by bacteria as a mechanism of Hg tolerance has not been pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8334f12525d52e5682ac1382ed34a40f
https://doi.org/10.1007/s00253-017-8239-z

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FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

Autor: Santosh L. Saraf, Patrick Kelly, Frans A. Kuypers, Patricia Schroeder, Eric Q. Wu, Sanjeev Forsyth, Theodosia A. Kalfa, Renae Mayer, Marilyn J. Telen, Punam Malik, Mark Lerman, Luke R. Smart, Jeremie H. Estepp, Kimberly Cruz, Maria D. Ribadeneira, R. Clark Brown

Publikováno v: Blood. 136:19-20

I NTRODUCTION: The hallmark of sickle cell disease (SCD) is hemoglobin S (HbS) polymerization upon deoxygenation, resulting in red blood cell (RBC) sickling, oxidative damage, membrane damage, hemolysis, cell adhesion, and vaso-occlusion. Exacerbatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1cf42e524e00d46570afb00e1e37038
https://doi.org/10.1182/blood-2020-134269

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Potential Application in Mercury Bioremediation of a Marine Sponge-Isolated Bacillus cereus strain Pj1

Autor: Tamar Barkay, Juliana F. Santos-Gandelman, Sharron Crane, Guilherme Muricy, Marinella S. Laport, Kimberly Cruz, Marcia Giambiagi-deMarval

Publikováno v: Current Microbiology. 69:374-380

Sponges are sessile marine invertebrates that can live for many years in the same location, and therefore, they have the capability to accumulate anthropogenic pollutants such as metals over a long period. Almost all marine sponges harbor a large num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418379ed5a2b2deda32fb7df8fbeffb7
https://doi.org/10.1007/s00284-014-0597-5

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