Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kimberly Cramer-Morales"'
Autor:
Katherine Sullivan, Kimberly Cramer-Morales, Daniel L McElroy, David A Ostrov, Kimberly Haas, Wayne Childers, Robert Hromas, Tomasz Skorski
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147230 (2016)
It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libra
Externí odkaz:
https://doaj.org/article/d0ce38a5e77f4bc28620ce675bd9464d
Autor:
Silvia Maifrede, Grazyna Hoser, Vera Gorbunova, Elisabeth Bolton-Gillespie, Tomasz Stoklosa, Kimberly Cramer-Morales, Sabine Cerny-Reiterer, Katarzyna Piwocka, Curt I. Civin, Jean C.Y. Wang, John E. Dick, Katherine J. Sullivan, Jaewong Lee, Peter Valent, Ravi Bhatia, Ilona Seferynska, Daniela Di Marcantonio, Huaqing Zhao, Yashodhara Dasgupta, Kolja Eppert, Margaret Nieborowska-Skorska, Daniel Gritsyuk, Stephen M. Sykes, Markus Müschen, Smita Bhatia, Min Li, Esteban Martínez, Tomasz Skorski, Mark D. Minden, Artur Slupianek, Lars Bullinger, Paulina Podszywalow-Bartnicka
Publikováno v:
Journal of Clinical Investigation
Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinase-mediated (DNA-PK-mediated) nonhomologous en
Autor:
Kara A. Scheibner, Jae-Woong Lee, Kimberly Cramer-Morales, Margaret Nieborowska-Skorska, Mariusz A. Wasik, Mhairi Copland, Tomasz Skorski, Michelle Padget, Curt I. Civin, David Irvine, Huimin Geng, Kimberly Haas, Markus Müschen, Feyruz V. Rassool, Wayne E. Childers, Tomasz Sliwinski, Darshan Roy, Artur Slupianek
Publikováno v:
Blood. 122:1293-1304
Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomeno
Autor:
Wayne E. Childers, Tomasz Skorski, Robert Hromas, Daniel L. McElroy, David A. Ostrov, Katherine J. Sullivan, Kimberly Cramer-Morales, Kimberly Haas
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147230 (2016)
PLoS ONE
PLoS ONE
It has been reported that inhibition of RAD52 either by specific shRNA or a small peptide aptamer induced synthetic lethality in tumor cell lines carrying BRCA1 and BRCA2 inactivating mutations. Molecular docking was used to screen two chemical libra
Autor:
Wayne E. Childers, Tomasz Skorski, Robert Hromas, Daniel L. McElroy, Kimberly Haas, David A. Ostrov, Katherine J. Sullivan, Margaret Nieborowska-Skorska, Kimberly Cramer-Morales, Alexander V. Mazin, Richard T. Pomerantz
Publikováno v:
Blood. 126:4434-4434
Altered DNA repair mechanisms are responsible for survival of leukemia stem cells (LSCs) and/or leukemia progenitor cells (LPCs) accumulating numerous lethal DNA double-strand breaks (DSBs). DSBs resulting from stalled/broken replication forks in pro
Autor:
Paulina Podszywalow-Bartnicka, Margaret Nieborowska-Skorska, Stephen M. Sykes, Artur Slupianek, Curt I. Civin, Markus Müschen, Elisabeth Bolton-Gillespie, Sabine Cerny-Reiterer, Tomasz Skorski, Grazyna Hoser, Tomasz Stoklosa, Katherine J. Sullivan, Mark D. Minden, Kimberly Cramer-Morales, Kolja Eppert, Chun Zhou, Peter Valent
Publikováno v:
Blood. 124:480-480
Leukemia stem cells (LSCs), and especially quiescent LSCs, have a dual role as tumor initiating and therapy-refractory cells. Therefore, even if anti-tumor treatment clears a disease burden consisting mostly of proliferating leukemia progenitor cells