Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kimberly C. Howland"'
Autor:
Abul K. Abbas, Douglas Dresnek, Matthew F. Krummel, Kimberly C. Howland, Samuel Edmondson, Pietro G. Andres
Publikováno v:
The Journal of Immunology. 172:5880-5886
T cell recognition of peptide-MHC complexes on APCs results in the aggregation of TCRs at a central supramolecular activation complex (c-SMAC) within a mature immunological synapse. T cells require a second “costimulatory” signal for activation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d84ee7d8e5ddba48c81cc0be9aa1cc4
https://doi.org/10.4049/jimmunol.172.10.5880
https://doi.org/10.4049/jimmunol.172.10.5880
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
Publikováno v:
Nature Immunology. 2:37-44
A region of the interleukin-2 (IL-2) promoter known as the RE/AP element is activated in concert by signals that originate from the T cell antigen receptor and the CD28 coreceptor. We show here that the serine-threonine kinase Akt can provide a costi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22134525811430ab95e6f10606f6586a
https://doi.org/10.1038/83144
https://doi.org/10.1038/83144
Publikováno v:
The Journal of Immunology. 164:4465-4470
Costimulation of T cell activation involves both the B7:CD28 as well as the CD40 ligand (CD40L):CD40 pathway. To determine the importance of these pathways to in vitro and in vivo T cell activation, a direct comparison was made of the responses of TC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501e86f4657d406a0158c3c41d195485
https://doi.org/10.4049/jimmunol.164.9.4465
https://doi.org/10.4049/jimmunol.164.9.4465
Autor:
Luke Barron, Pietro G. Andres, Ajay Nirula, Ali Sadra, Abul K. Abbas, Kimberly C. Howland, Lawrence P. Kane, Arthur Weiss, Douglas Dresnek, John B. Imboden
Publikováno v:
Nature immunology. 5(4)
CD28 costimulation is essential for CD4(+) T cell proliferation, survival, interleukin 2 (IL-2) production and T helper type 2 development. To define the nature of the signals that may drive different T cell responses, we have done a structure-functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9862176ad0165b63bbbfd4ee64ad6
https://pubmed.ncbi.nlm.nih.gov/15004555
https://pubmed.ncbi.nlm.nih.gov/15004555
Publikováno v:
Gastroenterology. 124:A154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::222a3082f657459e348518e5c83532b6
https://doi.org/10.1016/s0016-5085(03)80767-9
https://doi.org/10.1016/s0016-5085(03)80767-9