Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kimberly C. Brannen"'
Publikováno v:
ILAR journal. 57(2)
In the pharmaceutical industry, preclinical developmental and reproductive toxicity studies are conducted in laboratory animals in order to predict and prevent adverse effects of drugs on human reproductive health and development. However, these stud
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781493972067
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320afc4170fa23f3f5ea72bedfe0839a
https://doi.org/10.1007/7653_2016_67
https://doi.org/10.1007/7653_2016_67
Autor:
Yan Ma, Kimberly C. Brannen, Cindy X. Zhang, Julieta M. Panzica-Kelly, Karen Augustine-Rauch, Oliver P. Flint, Lois D. Lehman-McKeeman
Publikováno v:
Toxicological Sciences. 131:447-457
The mouse embryonic stem cell test (EST) is a 10-day screen for teratogenic potential developed to reduce animal use for embryotoxicity testing of chemicals (Spielmann, 2005; Spielmann et al., 1997). In this study, we used the cytotoxicity IC(50) val
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:52-68
The artemisinin antimalarials cause embryo death and malformations in animals by killing embryonic erythroblasts. Groups of pregnant rats (N = 4) were administered 35 and 48 µmol/kg artesunate and 17.2, 28.7, 48, 96, and 191 µmol/kg artelinic acid
Autor:
Cindy X. Zhang, Tracy L. Danberry, Annette Flood, Kimberly C. Brannen, Julieta M. Panzica-Kelly, Karen Augustine-Rauch, Judiann W. DeLan
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89:382-395
BACKGROUND: Recently we reported the development and optimization of a zebrafish teratogenicity assay using dechorionated AB strain embryos, a promising assay that was 87% concordant in correctly identifying in vivo teratogens and non-teratogens from
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 71:80-88
BACKGROUND: Exposure of pregnant outbred CD-1 mice to methanol during the period of gastrulation results in exencephaly, cleft palate, and cervical vertebra malformations [Rogers and Mole, Teratology 55: 364, 1997], while inbred C57BL/6J mice are sen
Publikováno v:
Developmental Neuroscience. 20:34-41
GABA acts as a trophic signal for cultured embryonic rat monoamine neurons by activating GABAA receptors. These effects are blocked by the organochlorine insecticide dieldrin and the classic GABAA antagonist bicuculline. Both dieldrin and another org
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 947
As a model for teratogenicity research, zebrafish are gaining popularity and creditability. Zebrafish embryos have been proven to be a highly valuable tool in genetics and developmental biology research and have advanced our understanding of a number
Publikováno v:
Methods in Molecular Biology ISBN: 9781627031301
As a model for teratogenicity research, zebrafish are gaining popularity and creditability. Zebrafish embryos have been proven to be a highly valuable tool in genetics and developmental biology research and have advanced our understanding of a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca89a265c66836c3f833c3f734b3a72e
https://doi.org/10.1007/978-1-62703-131-8_28
https://doi.org/10.1007/978-1-62703-131-8_28
Autor:
Frederic Moulin, Nelly Aranibar, Jeffrey H. Charlap, John C. Kozlosky, Oliver P. Flint, Liya Kang, John R. Megill, Joseph Horvath, Michael J. Bennett, Karl-Heinz Ott, Julieta M. Panzica-Kelly, Katherine M. Dubrow, William E. Achanzar, Kenneth E. Carlson, Haiying Zhang, Evan B. Janovitz, Mark Tirmenstein, Karen A. Augustine, Laura Patrone, Lindsay Tomlinson, Kimberly C. Brannen, Laura T. Rosini
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 129(2)
Ibipinabant (IBI), a potent cannabinoid-1 receptor (CB1R) antagonist, previously in development for the treatment of obesity, causes skeletal and cardiac myopathy in beagle dogs. This toxicity was characterized by increases in muscle-derived enzyme a