Výsledky vyhledávání - "Kimberly Blake"

Population Modeling Highlights Drug Disposition Differences Between Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in the Blood and Semen

Autor: Myron S. Cohen, Julie A. E. Nelson, Kimberly Blake, Craig Sykes, Amanda P. Schauer, Heather M.A. Prince, Jingxian Chen, Stephen A. Greene, Julie B. Dumond

Publikováno v: Clin Pharmacol Ther

Understanding antiretroviral disposition in the male genital tract, a distinct viral compartment, can provide insight for the eradication of HIV. Population pharmacokinetic modeling was conducted to investigate the disposition of tenofovir disoproxil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864094fe404ab53b37eac6a66216c33a
https://doi.org/10.1002/cpt.1464

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Genital Mucosal Drug Concentrations and anti-HIV Activity in Tenofovir-Based PrEP Products: Intravaginal Ring vs. Oral Administration

Autor: Xi Fang, Louise A. Ouattara, Gustavo F. Doncel, Andrea R. Thurman, Mackenzie L. Cottrell, Susan Ju, Jill L. Schwartz, Nikolas C. Vann, Craig Sykes, Kimberly Blake, Terry A. Jacot

Publikováno v: Journal of Acquired Immune Deficiency Syndromes (1999)

Supplemental Digital Content is Available in the Text.
Objective: To describe and compare systemic and local pharmacokinetics (PK) and cervicovaginal (CV) pharmacodynamics (PD) of oral tenofovir disoproxil fumarate (TDF) in combination with emtr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5021eb8d531bae40cf506b4f5371f0
https://pubmed.ncbi.nlm.nih.gov/34878438

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Antiretroviral Penetration and Drug Transporter Concentrations in the Spleens of Three Preclinical Animal Models and Humans

Autor: John K. Fallon, Lourdes Adamson, Angela D. M. Kashuba, Craig Sykes, Jason R. Pirone, Ramesh Akkina, Martina Kovarova, Amanda P. Schauer, Kimberly Blake, Leila Remling-Mulder, Philip C. Smith, Brian Van Horne, Paul A. Luciw, Aaron S. Devanathan, J. Victor Garcia, Nicole White

Publikováno v: Antimicrob Agents Chemother

Adequate antiretroviral (ARV) concentrations in lymphoid tissues are critical for optimal antiretroviral therapy (ART). While the spleen contains 25% of the body’s lymphocytes, there are minimal data on ARV penetration in this organ. This study qua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fce9413b373c18ee890be5925b1048
https://doi.org/10.1128/aac.01384-20

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Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs

Autor: Erin M. Burgunder, Lourdes Adamson, Craig Sykes, Kimberly Blake, Ramesh Akkina, Martina Kovarova, Aaron S. Devanathan, Nithya Srinivas, Nicole White, J. Victor Garcia, Jason R. Pirone, Paul A. Luciw, Angela D. M. Kashuba, Leila Remling-Mulder, Amanda P. Schauer, Elias P. Rosen

Publikováno v: Antimicrob Agents Chemother

For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a624af0134b107057c8fec400d2996a6
https://europepmc.org/articles/PMC7187610/

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Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair

Autor: Nicole White, Mackenzie L. Cottrell, Amanda P. Schauer, Bani Tamraz, Angela D. M. Kashuba, Craig Sykes, Kimberly Blake, Bryan B. Guzman

Publikováno v: Analytical and bioanalytical chemistry. 410(29)

Measurement of drug concentrations in hair provides a non-invasive approach to assess drug adherence. Here, we report on the development and validation of a method for the quantification of the antiretroviral dolutegravir (DTG) extracted from human h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9831ec65d9056daf64fe556a9191d0
https://pubmed.ncbi.nlm.nih.gov/30280227

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Attributions for Relatives' Behavior and Perceived Criticism: Studies With Community Participants and Patients With Anxiety Disorders

Autor: Kimberly Blake, Rachel A. Simmons, Dianne L. Chambless

Publikováno v: Behavior Therapy. 41:388-400

The relationship between perceived criticism from one’s relative and attributions about that relative’s behavior was examined in two studies. In Study 1, 50 community couples volunteered to participate in a study of marital interaction. Participa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce6eaaeefa646dd1665815513a81aa7
https://doi.org/10.1016/j.beth.2009.11.001

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Evidence That Normal Fetal Growth Can Be Noncontinuous

Autor: Ira M. Bernstein, Brian Wall, Gary J. Badger, Kimberly Blake

Publikováno v: Journal of Maternal-Fetal and Neonatal Medicine. 4:197-201

Fetal growth is presumed by current models to be continuous. We hypothesized that normal fetal growth is not continuous and that it demonstrates a pulsatile pattern. Fetal morphometric parameters were examined in 9 healthy women at an average interva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbbb8b4043970a966b774bb63dd3f6c
https://doi.org/10.3109/14767059509025370

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Construct validity of the Perceived Criticism Measure

Autor: Kimberly Blake, Dianne L. Chambless

Publikováno v: Behavior therapy. 40(2)

The construct validity of the Perceived Criticism Measure (PCM) was examined in 2 studies. In Study 1, 50 community couples participated in problem-solving interactions after which they rated interaction-specific perceived criticism and their critici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff41210e8f18bf4e7745e84a51d576dd
https://pubmed.ncbi.nlm.nih.gov/19433146

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The social isolation of young men with quadriplegia

Autor: Kimberly Blake

Publikováno v: Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses. 20(1)

This article describes the results of a study undertaken to identify perceptions of possible social isolation among individuals who become quadriplegic as young adults. Two focus group sessions were held with 4 male participants in each group. All th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53836af1d70b2b1fa67b6492e048077e
https://pubmed.ncbi.nlm.nih.gov/7855409

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