Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Kimberly B, Shepard"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 398 (2024)
Designing spray-dried particles for inhalation aims at specific physicochemical properties including a respirable aerodynamic diameter and adequate powder dispersibility. Leucine, an amphiphilic amino acid, has been shown to aid in optimizing bulk po
Externí odkaz:
https://doaj.org/article/12b805a38cd34eb5a643f951f85a2019
Autor:
Mani Ordoubadi, Kimberly B. Shepard, Hui Wang, Zheng Wang, Amanda M. Pluntze, Joseph P. Churchman, Reinhard Vehring
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 435 (2023)
Carrier-free spray-dried dispersions for pulmonary delivery, for which the demand is growing, frequently require the incorporation of dispersibility-enhancing excipients into the formulations to improve the efficacy of the dosage form. One of the mos
Externí odkaz:
https://doaj.org/article/20d0c84ee1354331a593f8f23866d5fb
Autor:
Deanna M. Mudie, Stephanie Buchanan, Aaron M. Stewart, Adam Smith, Kimberly B. Shepard, Nishant Biswas, Derrick Marshall, Alyssa Ekdahl, Amanda Pluntze, Christopher D. Craig, Michael M. Morgen, John M. Baumann, David T. Vodak
Publikováno v:
International Journal of Pharmaceutics: X, Vol 2, Iss , Pp 100042- (2020)
Although Amorphous Solid Dispersions (ASDs) effectively increase bioavailability, tablet mass can be high due to the large fraction of excipients needed to stabilize the amorphous drug in the solid state, extend drug supersaturation in solution and a
Externí odkaz:
https://doaj.org/article/8e1484a46ae7434bad8a08fa6b3ab5c2
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1130 (2022)
Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including proteins. In thi
Externí odkaz:
https://doaj.org/article/65415066ea6e45ddae1b22b1310eec79
Autor:
Kimberly B. Shepard, Na Li, Lynne S. Taylor, Michael M. Morgen, Jonathan L. Cape, Dmitry Zemlyanov, Bharat R. Mankani
Publikováno v:
Molecular Pharmaceutics
Spray drying is widely used in the manufacturing of amorphous solid dispersion (ASD) systems due to its fast drying rate, enabling kinetic trapping of the drug in amorphous form. Spray-drying conditions, such as solvent composition, can have a profou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2bb1f0bcffc9ea3eb2e8e9cd758d8f
https://doi.org/10.1021/acs.molpharmaceut.0c00798
https://doi.org/10.1021/acs.molpharmaceut.0c00798
Novel High-Drug-Loaded Amorphous Dispersion Tablets of Posaconazole; In Vivo and In Vitro Assessment
Autor:
John M. Baumann, Aaron M. Stewart, Timothy J. Brodeur, Michael M. Morgen, Nishant Biswas, Adam J. Smith, Kimberly B. Shepard, Deanna M. Mudie, David T. Vodak
Publikováno v:
Molecular Pharmaceutics. 17:4463-4472
Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and, therefore, a large dosage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0d4c41cbfc30ffc15571fe67ade33c8
https://doi.org/10.1021/acs.molpharmaceut.0c00471
https://doi.org/10.1021/acs.molpharmaceut.0c00471
Autor:
Daniel T. Regan, Deanna M. Mudie, Molly S. Adam, Kimberly B. Shepard, John M. Baumann, Michael M. Morgen, David T. Vodak
Publikováno v:
Powder Technology. 362:221-230
Spray drying is one of the most broadly applicable and widely used methods of producing amorphous solid dispersions (ASDs). ASDs can improve the oral absorption of poorly water-soluble active pharmaceutical ingredients. Eudragit L100 is an appealing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce9819c7e3edb38ff40f1f0b6a2f1b58
https://doi.org/10.1016/j.powtec.2019.12.013
https://doi.org/10.1016/j.powtec.2019.12.013
Autor:
David Revelli, Jonathan L. Cape, Lauren Switala, Amanda M. Pluntze, John M. Baumann, Michael Banks, Yue Zhou, Philip J. Kuehl, Kimberly B. Shepard, Julia C. Oddo, Molly S. Adam, David T. Vodak
Publikováno v:
AAPS PharmSciTech
Local delivery of biotherapeutics to the lung holds great promise for treatment of lung diseases, but development of physically stable, biologically active dry powder formulations of large molecules for inhalation has remained a challenge. Here, spra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f28cd5b4865b05b9a55ffcbc8cfe24
https://doi.org/10.1208/s12249-021-02095-7
https://doi.org/10.1208/s12249-021-02095-7
Autor:
Deanna M, Mudie, Aaron M, Stewart, Nishant, Biswas, Timothy J, Brodeur, Kimberly B, Shepard, Adam, Smith, Michael M, Morgen, John M, Baumann, David T, Vodak
Publikováno v:
Molecular pharmaceutics. 17(12)
Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and, therefore, a large dosage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0dd39827cda281513d0be2ae2937550
https://pubmed.ncbi.nlm.nih.gov/32835489
https://pubmed.ncbi.nlm.nih.gov/32835489
Autor:
Nishant Biswas, Kimberly B. Shepard, Stephanie S. Buchanan, Adam J. Smith, Derrick J Marshall, Christopher D. Craig, Deanna M. Mudie, Aaron M. Stewart, Amanda M. Pluntze, Michael M. Morgen, John M. Baumann, Alyssa Ekdahl, David T. Vodak
Publikováno v:
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X, Vol 2, Iss, Pp 100042-(2020)
International Journal of Pharmaceutics: X, Vol 2, Iss, Pp 100042-(2020)
Although Amorphous Solid Dispersions (ASDs) effectively increase bioavailability, tablet mass can be high due to the large fraction of excipients needed to stabilize the amorphous drug in the solid state, extend drug supersaturation in solution and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e954d4271c80481b31c23708fdaae260
http://europepmc.org/articles/PMC7058468
http://europepmc.org/articles/PMC7058468