Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kimberly A. Gwin"'
Autor:
Gordon J. Ruan, Xiaosheng Wu, Kimberly A. Gwin, Michelle K Manske, Jithma P. Abeykoon, Vaishali Bhardwaj, Taylor L. Witter, Matthew J. Schellenberg, Kari G Rabe, Neil E. Kay, Sameer A. Parikh, Thomas E. Witzig
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
The open reading frame 8 (ORF8) protein, encoded by the SARS-CoV-2 virus after infection, stimulates monocytes/macrophages to produce pro-inflammatory cytokines. We hypothesized that a positive ex vivo monocyte response to ORF8 protein pre-COVID-19 w
Externí odkaz:
https://doaj.org/article/01329c39a20f4a1cb4a1181ddc685ff6
Autor:
Baustin M. Welch, Bryce A. Manso, Kimberly A. Gwin, Petra K. Lothert, Sameer A. Parikh, Neil E. Kay, Kay L. Medina
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD19+ CD5+ clonal B lymphocytes in the blood, bone marrow, and peripheral lymphoid organs. Treatment options for patients range from historical chemoimmunotherapy (CIT) to sma
Externí odkaz:
https://doaj.org/article/3af2d62a88864d4880ba353b1c54c869
Autor:
Xiaosheng Wu, Michelle K. Manske, Gordon J. Ruan, Taylor L. Witter, Kevin E. Nowakowski, Jithma P. Abeykoon, Xinyi Tang, Yue Yu, Kimberly A. Gwin, Annie Wu, Vanessa Taupin, Vaishali Bhardwaj, Jonas Paludo, Surendra Dasari, Haidong Dong, Stephen M. Ansell, Andrew D. Badley, Matthew J. Schellenberg, Thomas E. Witzig
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106929- (2023)
Summary: Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the viru
Externí odkaz:
https://doaj.org/article/008c8e98333d4304b6e7fee69dec3a76
Autor:
Bryce A. Manso, Jordan E. Krull, Kimberly A. Gwin, Petra K. Lothert, Baustin M. Welch, Anne J. Novak, Sameer A. Parikh, Neil E. Kay, Kay L. Medina
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101994- (2021)
Summary: TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture
Externí odkaz:
https://doaj.org/article/3512d80d493a465ba952a1c7986839c3
Autor:
Xiaosheng Wu, Michelle K. Manske, Gordon J. Ruan, Taylor L. Witter, Kevin E. Nowakowski, Jithma P. Abeykoon, Xinyi Tang, Yue Yu, Kimberly A. Gwin, Annie Wu, Vanessa Taupin, Vaishali Bhardwaj, Jonas Paludo, Surendra Dasari, Haidong Dong, Stephen M. Ansell, Andrew D. Badley, Matthew J. Schellenberg, Thomas E. Witzig
COVID-19 is a significant cause of morbidity and mortality in blood cancer patients, especially those on immunosuppressive therapy. Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcaffd6955ded03bd44ff3e533144642
https://doi.org/10.1101/2021.12.02.470978
https://doi.org/10.1101/2021.12.02.470978
Autor:
Kay L Medina, Sarah N Tangen, Lauren M Seaburg, Puspa Thapa, Kimberly A Gwin, Virginia Smith Shapiro
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78408 (2013)
B-cell-biased lymphoid progenitors (BLPs) and Pre-pro B cells lie at a critical juncture between B cell specification and commitment. However, both of these populations are heterogenous, which hampers investigation into the molecular changes that occ
Externí odkaz:
https://doaj.org/article/c6c441f284724124a84b17f84670151e
Autor:
Kay L. Medina, Petra K. Lothert, Sameer A. Parikh, Bryce A. Manso, Neil E. Kay, Anne J. Novak, Kimberly A. Gwin, Baustin M. Welch, Jordan E. Krull
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101994-(2021)
iScience, Vol 24, Iss 1, Pp 101994-(2021)
Summary TNFα is implicated in chronic lymphocytic leukemia (CLL) immunosuppression and disease progression. TNFα is constitutively produced by CLL B cells and is a negative regulator of bone marrow (BM) myelopoiesis. Here, we show that co-culture o
Autor:
Bryce A. Manso, Charla R. Secreto, Neil E. Kay, Anne J. Novak, Wei Ding, Kimberly A. Gwin, Jordan E. Krull, Petra K. Lothert, Sameer A. Parikh, Kay L. Medina
Publikováno v:
Blood. 134:4276-4276
The current paradigms of known peripheral immune abnormalities in B-Chronic Lymphocytic Leukemia (CLL) are not able to consistently explain patient complications and it is difficult to correct a given CLL patient's immune status. Here, we expand on o
Autor:
Wei Ding, Kimberly A. Gwin, Henan Zhang, Neil E. Kay, Sameer A. Parikh, Kay L. Medina, Charla R. Secreto, Bryce A. Manso, Molly G. Mikkelson
Publikováno v:
Leukemia. 33(3)
The consequences of immune dysfunction in B-chronic lymphocytic leukemia (CLL) likely relate to the incidence of serious recurrent infections and second malignancies that plague CLL patients. The well-described immune abnormalities are not able to co
Autor:
Fan Chi Hsu, Virginia Smith Shapiro, Joseph J. Dolence, Mariya B. Shapiro, Kimberly A. Gwin, Kay L. Medina
Publikováno v:
Immunity, Inflammation and Disease. 3:103-117
B lymphopoiesis in bone marrow (BM) is critical for maintaining a diverse peripheral B cell pool to fight infection and establish lifelong immunity. The generation of immature B cells is reduced in Flt3-ligand (FL-/-) mice leading to deficiencies in