Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Kimberly A. Cooney"'
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Akademický článek
Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
Autor: Eugene Nyamugenda, Haven Griffin, Susan Russell, Kimberly A. Cooney, Nicholas S. Kowalczyk, Ishrar Islam, Kevin D. Phelan, Giulia Baldini
Publikováno v: iScience, Vol 23, Iss 5, Pp - (2020)
Summary: In the melanocortin pathway, melanocortin-4 receptor (MC4R) functions to control energy homeostasis. MC4R is expressed in a sub-population of Sim1 neurons (Sim1/MC4R neurons) and functions in hypothalamic paraventricular nuclei (PVN) to cont
Externí odkaz: https://doaj.org/article/5016c2a568894aad8ece56d21a2a46bb
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3
A Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion
Autor: Woojin M. Han, Frederick Strobel, Kimberly A. Cooney, Rebecca D. Levit, Lanfang Wang, Andrés J. García, Laura Hansen, Michael N. Sayegh
Publikováno v: Arterioscler Thromb Vasc Biol
Objective: Adenosine is an important vasodilatory, anti-inflammatory, and antithrombotic agent; however, its delivery for the treatment of cardiovascular diseases is challenging due to the drug’s short half-life and dose-limiting side effects. Peri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d39d5c5974b4808f33dcb24474172f3
https://doi.org/10.1161/atvbaha.120.315428
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4
Adenosine from a biologic source regulates neutrophil extracellular traps (NETs)
Autor: Lanfang Wang, Eric Shin, Juline Deppen, Kai Xu, Rebecca D. Levit, Sydney C Ginn, Kimberly A. Cooney
Publikováno v: J Leukoc Biol
Neutrophil extracellular traps (NETs) are implicated in autoimmune, thrombotic, malignant, and inflammatory diseases; however, little is known of their endogenous regulation under basal conditions. Inflammatory effects of neutrophils are modulated by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5015beee8c36bfcc056506d486310eb0
https://doi.org/10.1002/jlb.3vma0918-374r
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6
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Autor: Zachary Strongin, Timothy N. Hoang, Rebecca D. Levit, Shelly Wang, Sherrie Jean, Kimberly A. Cooney, Susan Pereira Ribeiro, Mirko Paiardini, Lanfang Wang, Gregory K. Tharp, Rafick Pierre Sekaly, Michael Nekorchuk, Elise G. Viox, Raymond F. Schinazi, Justin L. Harper, Jacob D. Estes, Steven E. Bosinger, Michelle Y.H. Lee, Hilmi Al-Shakhshir, Rachelle L. Stammen, Kathleen Busman-Sahay, Arun K. Boddapati, Daniela Weiskopf, Sijia Tao, Anne Piantadosi, Guido Silvestri, Kathryn L. Pellegrini, Maria Pino, Michael N. Sayegh, Fawn Connor-Stroud, Thomas H. Vanderford, Tristan R. Horton, Jesse J. Waggoner, Joyce Cohen, Olivia M. Delmas, Jennifer S. Wood, Peter D. Filev, Carly E. Starke, Amit A. Upadhyay, Sudhir Pai Kasturi, Ernestine A. Mahar, Shannon Kirejczyk, Elizabeth N. Beagle, Sanjeev Gumber, Keivan Zandi
Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1
Cell
SARS-CoV-2 induced hypercytokinemia and inflammation are critically associated with COVID-19 disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor, is currently being investigated in COVID-19 clinical trials. Here, we investigated the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4714908327d21cfa2db754cec36a91
https://pubmed.ncbi.nlm.nih.gov/32995780
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7
Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity
Autor: Nicholas S. Kowalczyk, Haven Griffin, Kevin D. Phelan, Susan Russell, Eugene Nyamugenda, Giulia Baldini, Ishrar Islam, Kimberly A. Cooney
Publikováno v: iScience
iScience, Vol 23, Iss 5, Pp-(2020)
Summary In the melanocortin pathway, melanocortin-4 receptor (MC4R) functions to control energy homeostasis. MC4R is expressed in a sub-population of Sim1 neurons (Sim1/MC4R neurons) and functions in hypothalamic paraventricular nuclei (PVN) to contr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f02f6d32ca5a756b2adcf697d217fc
http://europepmc.org/articles/PMC7240135
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8
Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum
Autor: Srividhya Iyer, Kimberly A. Cooney, Susan Russell, Gunnar Boysen, Alan J. Tackett, Tiffany K. Miles, Kevin D. Phelan, Eugene Nyamugenda, Haven Griffin, Giulia Baldini, Brian Koss, Marcus Trentzsch
Publikováno v: Cell Death Discovery, Vol 6, Iss 1, Pp 1-16 (2020)
Cell Death Discovery
Genetic obesity increases in liver phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio, inducing endoplasmic reticulum (ER) stress without concomitant increase of ER chaperones. Here, it is found that exposing mice to a palm oil-based high f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02acfc99e94461b5c691f794246742a9
https://doi.org/10.1038/s41420-020-0241-z
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10
Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists
Autor: Giulia Baldini, Lex H.T. Van der Ploeg, Brent M. Molden, Kirk West, Kimberly A. Cooney
Publikováno v: Molecular Endocrinology. 29:1619-1633
The melanocortin-4 receptor (MC4R) is a G protein-coupled receptor expressed in the brain, where it controls energy balance through pathways including α-melanocyte-stimulating hormone (α-MSH)-dependent signaling. We have reported that the MC4R can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e19ead42f931b90bdffbac249a34c4
https://doi.org/10.1210/me.2015-1071
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