Zobrazeno 1 - 10
of 683
pro vyhledávání: '"Kimberly A Smith"'
Autor:
Mean-Hwan Kim, Cristina Radaelli, Elliot R Thomsen, Deja Monet, Thomas Chartrand, Nikolas L Jorstad, Joseph T Mahoney, Michael J Taormina, Brian Long, Katherine Baker, Trygve E Bakken, Luke Campagnola, Tamara Casper, Michael Clark, Nick Dee, Florence D'Orazi, Clare Gamlin, Brian E Kalmbach, Sara Kebede, Brian R Lee, Lindsay Ng, Jessica Trinh, Charles Cobbs, Ryder P Gwinn, C Dirk Keene, Andrew L Ko, Jeffrey G Ojemann, Daniel L Silbergeld, Staci A Sorensen, Jim Berg, Kimberly A Smith, Philip R Nicovich, Tim Jarsky, Hongkui Zeng, Jonathan T Ting, Boaz P Levi, Ed Lein
Publikováno v:
eLife, Vol 12 (2023)
Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well investigated in human cortex, where ther
Externí odkaz:
https://doaj.org/article/9eba18f71257492da7a084c53084bbca
Autor:
Trygve E Bakken, Cindy TJ van Velthoven, Vilas Menon, Rebecca D Hodge, Zizhen Yao, Thuc Nghi Nguyen, Lucas T Graybuck, Gregory D Horwitz, Darren Bertagnolli, Jeff Goldy, Anna Marie Yanny, Emma Garren, Sheana Parry, Tamara Casper, Soraya I Shehata, Eliza R Barkan, Aaron Szafer, Boaz P Levi, Nick Dee, Kimberly A Smith, Susan M Sunkin, Amy Bernard, John Phillips, Michael J Hawrylycz, Christof Koch, Gabe J Murphy, Ed Lein, Hongkui Zeng, Bosiljka Tasic
Publikováno v:
eLife, Vol 10 (2021)
Abundant evidence supports the presence of at least three distinct types of thalamocortical (TC) neurons in the primate dorsal lateral geniculate nucleus (dLGN) of the thalamus, the brain region that conveys visual information from the retina to the
Externí odkaz:
https://doaj.org/article/f603ae63e1374a53a6a3312be848bb59
Autor:
Brian R Lee, Agata Budzillo, Kristen Hadley, Jeremy A Miller, Tim Jarsky, Katherine Baker, DiJon Hill, Lisa Kim, Rusty Mann, Lindsay Ng, Aaron Oldre, Ram Rajanbabu, Jessica Trinh, Sara Vargas, Thomas Braun, Rachel A Dalley, Nathan W Gouwens, Brian E Kalmbach, Tae Kyung Kim, Kimberly A Smith, Gilberto Soler-Llavina, Staci Sorensen, Bosiljka Tasic, Jonathan T Ting, Ed Lein, Hongkui Zeng, Gabe J Murphy, Jim Berg
Publikováno v:
eLife, Vol 10 (2021)
The Patch-seq approach is a powerful variation of the patch-clamp technique that allows for the combined electrophysiological, morphological, and transcriptomic characterization of individual neurons. To generate Patch-seq datasets at scale, we ident
Externí odkaz:
https://doaj.org/article/34e4a68dbc504e52805f073d4e7d3060
Autor:
Trygve E Bakken, Rebecca D Hodge, Jeremy A Miller, Zizhen Yao, Thuc Nghi Nguyen, Brian Aevermann, Eliza Barkan, Darren Bertagnolli, Tamara Casper, Nick Dee, Emma Garren, Jeff Goldy, Lucas T Graybuck, Matthew Kroll, Roger S Lasken, Kanan Lathia, Sheana Parry, Christine Rimorin, Richard H Scheuermann, Nicholas J Schork, Soraya I Shehata, Michael Tieu, John W Phillips, Amy Bernard, Kimberly A Smith, Hongkui Zeng, Ed S Lein, Bosiljka Tasic
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209648 (2018)
Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq provides less biased cellular coverage, does not appear to suffer cell isolation-b
Externí odkaz:
https://doaj.org/article/a582d6cca35342eaac24aa2cf90cf4a8
Autor:
Jeremy A Miller, Angela Guillozet-Bongaarts, Laura E Gibbons, Nadia Postupna, Anne Renz, Allison E Beller, Susan M Sunkin, Lydia Ng, Shannon E Rose, Kimberly A Smith, Aaron Szafer, Chris Barber, Darren Bertagnolli, Kristopher Bickley, Krissy Brouner, Shiella Caldejon, Mike Chapin, Mindy L Chua, Natalie M Coleman, Eiron Cudaback, Christine Cuhaciyan, Rachel A Dalley, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadezhda I Dotson, Michael Fisher, Nathalie Gaudreault, Garrett Gee, Terri L Gilbert, Jeff Goldy, Fiona Griffin, Caroline Habel, Zeb Haradon, Nika Hejazinia, Leanne L Hellstern, Steve Horvath, Kim Howard, Robert Howard, Justin Johal, Nikolas L Jorstad, Samuel R Josephsen, Chihchau L Kuan, Florence Lai, Eric Lee, Felix Lee, Tracy Lemon, Xianwu Li, Desiree A Marshall, Jose Melchor, Shubhabrata Mukherjee, Julie Nyhus, Julie Pendergraft, Lydia Potekhina, Elizabeth Y Rha, Samantha Rice, David Rosen, Abharika Sapru, Aimee Schantz, Elaine Shen, Emily Sherfield, Shu Shi, Andy J Sodt, Nivretta Thatra, Michael Tieu, Angela M Wilson, Thomas J Montine, Eric B Larson, Amy Bernard, Paul K Crane, Richard G Ellenbogen, C Dirk Keene, Ed Lein
Publikováno v:
eLife, Vol 6 (2017)
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer’s disease (AD) have not led to effective treatments,
Externí odkaz:
https://doaj.org/article/34f96814eec64ca19f44cf823cbe4aa1
Autor:
Nikolai C. Dembrow, Scott Sawchuk, Rachel Dalley, Ximena Opitz-Araya, Mark Hudson, Cristina Radaelli, Lauren Alfiler, Sarah Walling-Bell, Darren Bertagnolli, Jeff Goldy, Nelson Johansen, Jeremy A. Miller, Kamiliam Nasirova, Scott F. Owen, Alejandro Parga-Becerra, Naz Taskin, Michael Tieu, David Vumbaco, Natalie Weed, Julia Wilson, Brian R. Lee, Kimberly A. Smith, Staci A. Sorensen, William J. Spain, Ed S. Lein, Steve I. Perlmutter, Jonathan T. Ting, Brian E. Kalmbach
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114718- (2024)
Summary: Large-scale analysis of single-cell gene expression has revealed transcriptomically defined cell subclasses present throughout the primate neocortex with gene expression profiles that differ depending upon neocortical region. Here, we test w
Externí odkaz:
https://doaj.org/article/f682c29824904980a5a21055862f0370
Autor:
Julie Ann Harris, Karla E Hirokawa, Staci A Sorensen, Hong eGu, Maya eMills, Lydia L Ng, Phillip eBohn, Marty eMortrud, Benjamin eOuellette, Jolene eKidney, Kimberly A Smith, Chinh eDang, Susan eSunkin, Amy eBernard, Seung Wook Oh, Linda eMadisen, Hongkui eZeng
Publikováno v:
Frontiers in Neural Circuits, Vol 8 (2014)
Significant advances in circuit-level analyses of the brain require tools that allow for labeling, modulation of gene expression, and monitoring and manipulation of cellular activity in specific cell types and/or anatomical regions. Large-scale proje
Externí odkaz:
https://doaj.org/article/277e0c714c2241699cb6edb55972c225
Autor:
Adriana M Zimnicka, Haiyang Tang, Qiang Guo, Frank K Kuhr, Myung-Jin Oh, Jun Wan, Jiwang Chen, Kimberly A Smith, Dustin R Fraidenburg, Moumita S R Choudhury, Irena Levitan, Roberto F Machado, Jack H Kaplan, Jason X-J Yuan
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90544 (2014)
Pulmonary vascular remodeling and increased arterial wall stiffness are two major causes for the elevated pulmonary vascular resistance and pulmonary arterial pressure in patients and animals with pulmonary hypertension. Cellular copper (Cu) plays an
Externí odkaz:
https://doaj.org/article/13005cca34f249ebac95ee232fff417b
Autor:
Katie M. Ellison, Aseel El Zein, Chelsi Reynolds, Sarah E. Ehrlicher, Julianne G. Clina, Tsz-Kiu Chui, Kimberly A. Smith, James O. Hill, Holly R. Wyatt, R. Drew Sayer
Publikováno v:
Nutrients, Vol 16, Iss 17, p 2874 (2024)
Background: Obesity is commonly aggregated with indices of metabolic health. Proponents of body positivity approaches question whether body size is a determinant of health and well-being. Our objective was to conduct an exploratory factor analysis (E
Externí odkaz:
https://doaj.org/article/1b38d7190fd449ff9a0036b5c9e2c307
Autor:
Carol L Thompson, Jonathan P Wisor, Chang-Kyu Lee, Sayan D Pathak, Dmitry Gerashchenko, Kimberly A Smith, Shanna R Fischer, Chihchau L Kuan, Susan M Sunkin, Lydia L Ng, Christopher Lau, Mike Hawrylycz, Allan R Jones, Thomas Kilduff, Edward S Lein
Publikováno v:
Frontiers in Neuroscience, Vol 4 (2010)
Sleep deprivation (SD) leads to a suite of cognitive and behavioral impairments, and yet the molecular consequences of SD in the brain are poorly understood. Using a systematic immediate-early gene mapping to detect neuronal activation, the consequen
Externí odkaz:
https://doaj.org/article/fe125b5a6c004614aac265269d4c1310