Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Kimberly A Kraynyak"'
1
Akademický článek
Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors
Autor: Laurent Humeau, David Weiner, Robert H Vonderheide, Matthew P Morrow, Trevor McMullan, Anthony F Shields, Ashish V Chintakuntlawar, Kimberly A Kraynyak, Autumn J McRee, Jennifer M Johnson, Weijing Sun, Jan Pawlicki, Albert J Sylvester, Robert Samuels, Joseph J Kim, Jean D Boyer, Jeffrey M Skolnik
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Human telomerase reverse transcriptase (hTERT) is frequently classified as a ‘universal’ tumor associated antigen due to its expression in a vast number of cancers. We evaluated plasmid DNA-encoded hTERT as an immunotherapy across nine
Externí odkaz: https://doaj.org/article/a019d7273be04e4cbb43557f12c156de
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2
Akademický článek
Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis
Autor: Charu Aggarwal, Roger B. Cohen, Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Jocelyn Cheung, Kelsie Dickerson, Veronique Schulten, Dawson Knoblock, Elisabeth Gillespie, Joshua M. Bauml, Jian Yan, Malissa Diehl, Jean Boyer, Michael Dallas, J. Joseph Kim, David B Weiner, Jeffrey M. Skolnik
Publikováno v: Vaccines, Vol 8, Iss 1, p 56 (2020)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually associated with human papilloma virus (HPV) subtypes 6, 11. INO-3106 is a DNA plasmid-based im
Externí odkaz: https://doaj.org/article/f4b8a7fdd42a4cab99ccb32b9c547661
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3
Akademický článek
Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100
Autor: Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Xuefei Shen, Dinah Amante, Lindsay Sakata, Lamar Parker, Jian Yan, Jean Boyer, Christian Roh, Laurent Humeau, Amir S Khan, Kate Broderick, Kathleen Marcozzi-Pierce, Mary Giffear, Jessica Lee, Cornelia L Trimble, J Joseph Kim, Niranjan Y Sardesai, David B Weiner, Mark L Bagarazzi
Publikováno v: Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
We have previously demonstrated the immunogenicity of VGX-3100, a multicomponent DNA immunotherapy for the treatment of Human Papillomavirus (HPV)16/18-positive CIN2/3 in a phase 1 clinical trial. Here, we report on the ability to boost immune respon
Externí odkaz: https://doaj.org/article/6cdec84404f44e6da5cce111757a5347
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