Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kimberly, Newberry"'
Autor:
Carolyn Diane Dzierba, Debra J. Post-Munson, Ronald J. Knox, Lorin A. Thompson, Shuya Wang, Matthew G. Soars, Michele Matchett, Linda J. Bristow, James Herrington, Clotilde Bourin, Amy Newton, Rick L. Pieschl, Eric Shields, Amy Easton, Kathy Mosure, Guanglin Luo, Kimberly Newberry, Ling Chen, John D. Graef, Arun K. Senapati, Nicholas A. Meanwell, Digavalli V. Sivarao
Publikováno v:
Journal of Medicinal Chemistry. 62:831-856
3-Aryl-indole and 3-aryl-indazole derivatives were identified as potent and selective Nav1.7 inhibitors. Compound 29 was shown to be efficacious in the mouse formalin assay and also reduced complete Freund’s adjuvant (CFA)-induced thermal hyperalge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8738aee38a77abf37b839d8d841c0ca8
https://doi.org/10.1021/acs.jmedchem.8b01550
https://doi.org/10.1021/acs.jmedchem.8b01550
Autor:
Mahesh Paschapur, Jeffrey M. Brown, Tanmaya Bastia, Lawrence R. Marcin, Jayakumar Sankara Warrier, Srinivasan Thangathirupathy, Joanne J. Bronson, Raja Reddy Kallem, Huiping Zhang, Jyoti Gulia, Alda Fernandes, Digavalli V. Sivarao, Deborah Keavy, Amy Newton, Jianqing Li, Pattipati S. Naidu, Kuchibhotla Vijaya Kumar, James Kempson, Michael R. Weed, Rick L. Pieschl, Mark Bookbinder, Charlie F. Albright, Kimberly Newberry, Yu-Wen Li, Dalton King, Manjunath Ramarao, Jean Simmermacher, Linda J. Bristow, Meenakshee Sinha, Eric Shields, Lorin A. Thompson, John E. Macor, Charulatha Sanmathi, Imadul Islam, B.N. Srikumar, Richard E. Olson, John D. Graef, Arvind Mathur, Narasimharaju Kalidindi, Joseph Polino, Michael Sinz, Thaddeus F. Molski, Jayant Aher, Reeba K. Vikramadithyan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 363:377-393
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3S,4S)-3-fluoro-1-((R)-1-(4-methylbenzyl)-2-oxopyrrolidin-3-yl)piperidin-4-yl)phenyl dihydrogen phosphate (BMS-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fc12be7607ec5d5401f625fdca24cd2
https://doi.org/10.1124/jpet.117.242784
https://doi.org/10.1124/jpet.117.242784
Autor:
Debra J. Post-Munson, Amy Easton, Carolyn Diane Dzierba, Amy Newton, Yong-Jin Wu, Ronald J. Knox, Kevin J. Robbins, Jason M. Guernon, Clotilde Bourin, Ramkumar Rajamani, Richard E. Olson, James Herrington, Michele Matchett, Kimberly Newberry, John D. Graef, Jianliang Shi, Lorin A. Thompson, Shuya Wang, Jonathan L. Ditta, Nicholas A. Meanwell, Rick L. Pieschl, Matthew G. Soars, Linda J. Bristow, Kathleen W. Mosure
Publikováno v:
Journal of Medicinal Chemistry. 60:2513-2525
By taking advantage of certain features in piperidine 4, we developed a novel series of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Nav1.7 inhibitors. However, compound 24, one of the early analogs, failed to red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70eeeaf9d44c1cee668426b1f9c6fa0f
https://doi.org/10.1021/acs.jmedchem.6b01918
https://doi.org/10.1021/acs.jmedchem.6b01918
Autor:
Guanglin, Luo, Ling, Chen, Amy, Easton, Amy, Newton, Clotilde, Bourin, Eric, Shields, Kathy, Mosure, Matthew G, Soars, Ronald J, Knox, Michele, Matchett, Rick L, Pieschl, Debra J, Post-Munson, Shuya, Wang, James, Herrington, John, Graef, Kimberly, Newberry, Digavalli V, Sivarao, Arun, Senapati, Linda J, Bristow, Nicholas A, Meanwell, Lorin A, Thompson, Carolyn, Dzierba
Publikováno v:
Journal of medicinal chemistry. 62(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65eb13dd58efb30cbfdb34202aa50d9e
https://pubmed.ncbi.nlm.nih.gov/30576602
https://pubmed.ncbi.nlm.nih.gov/30576602
Autor:
Linda J, Bristow, Jyoti, Gulia, Michael R, Weed, Bettadapura N, Srikumar, Yu-Wen, Li, John D, Graef, Pattipati S, Naidu, Charulatha, Sanmathi, Jayant, Aher, Tanmaya, Bastia, Mahesh, Paschapur, Narasimharaju, Kalidindi, Kuchibhotla Vijaya, Kumar, Thaddeus, Molski, Rick, Pieschl, Alda, Fernandes, Jeffrey M, Brown, Digavalli V, Sivarao, Kimberly, Newberry, Mark, Bookbinder, Joseph, Polino, Deborah, Keavy, Amy, Newton, Eric, Shields, Jean, Simmermacher, James, Kempson, Jianqing, Li, Huiping, Zhang, Arvind, Mathur, Raja Reddy, Kallem, Meenakshee, Sinha, Manjunath, Ramarao, Reeba K, Vikramadithyan, Srinivasan, Thangathirupathy, Jayakumar, Warrier, Imadul, Islam, Joanne J, Bronson, Richard E, Olson, John E, Macor, Charlie F, Albright, Dalton, King, Lorin A, Thompson, Lawrence R, Marcin, Michael, Sinz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(3)
(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd1b2a02de8ae2373f7595e246bd87cd
https://pubmed.ncbi.nlm.nih.gov/28954811
https://pubmed.ncbi.nlm.nih.gov/28954811
Autor:
Yong-Jin, Wu, Jason, Guernon, Jianliang, Shi, Jonathan, Ditta, Kevin J, Robbins, Ramkumar, Rajamani, Amy, Easton, Amy, Newton, Clotilde, Bourin, Kathleen, Mosure, Matthew G, Soars, Ronald J, Knox, Michele, Matchett, Rick L, Pieschl, Debra J, Post-Munson, Shuya, Wang, James, Herrington, John, Graef, Kimberly, Newberry, Linda J, Bristow, Nicholas A, Meanwell, Richard, Olson, Lorin A, Thompson, Carolyn, Dzierba
Publikováno v:
Journal of medicinal chemistry. 60(6)
By taking advantage of certain features in piperidine 4, we developed a novel series of cyclohexylamine- and piperidine-based benzenesulfonamides as potent and selective Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e80c1ea1fde8494818d5f15453edf10a
https://pubmed.ncbi.nlm.nih.gov/28234467
https://pubmed.ncbi.nlm.nih.gov/28234467
Autor:
Richard E. Olson, Ivar M. McDonald, Kimberly Newberry, Linda J. Bristow, Thaddeus F. Molski, Nicholas J. Lodge, Kelli M. Jones, Rick L. Pieschl, John E. Macor, Debra J. Post-Munson, Ryan Westphal, Ping Chen, Yu-Wen Li, Amy Easton, Yulia Benitex, Robert Zaczek, Yukiko Asaka, James Herrington, Siva Digavalli, Regina Miller, Daniel G. Morgan
Publikováno v:
European journal of pharmacology. 807
The α7 nicotinic acetylcholine receptor is thought to play an important role in human cognition. Here we describe the in vivo effects of BMS-902483, a selective potent α7 nicotinic acetylcholine receptor partial agonist, in relationship to α7 nico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f575d42b7bec741272adfcfbfcd33b57
https://pubmed.ncbi.nlm.nih.gov/28438647
https://pubmed.ncbi.nlm.nih.gov/28438647
Autor:
Debra J. Post-Munson, Clotilde Bourin, Carolyn Diane Dzierba, Ling Chen, Michele Matchett, John D. Graef, Ronald J. Knox, Kimberly Newberry, Guanglin Luo, James B Herrington, Amy Newton, Matthew G. Soars, Arun K. Senapati, Kathy Mosure, Nicholas A. Meanwell, Digavalli V. Sivarao, Shuya Wang, Rick L. Pieschl, Linda J. Bristow, Eric Shields, Lorin A. Thompson, Amy Easton
Publikováno v:
Journal of Medicinal Chemistry. 62:2213-2213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b1cafdbe761a2ee2b84d1a8c68e354
https://doi.org/10.1021/acs.jmedchem.9b00202
https://doi.org/10.1021/acs.jmedchem.9b00202
Autor:
Kimberly Newberry, Kevin W. Gillman, Matthew T. Taber, Snjezana Lelas, Tanya L. Wallace-Boone, Yu-Wen Li, Carl D. Davis, Rick L. Pieschl, Nicholas J. Lodge, John E. Macor, Thaddeus F. Molski, Michael F. Parker, Joanne J. Bronson, Amy Newton
Publikováno v:
Neuropharmacology. 73:232-240
The known interactions between the serotonergic and neurokinin systems suggest that serotonin reuptake inhibitor (SSRIs) efficacy may be improved by neurokinin-1 receptor (NK1R) antagonism. In the current studies combination of a subeffective dose of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2478511e61245db99427a73ea617f5
https://doi.org/10.1016/j.neuropharm.2013.05.038
https://doi.org/10.1016/j.neuropharm.2013.05.038
Autor:
Kimberly Newberry, Amy Newton, Laszlo Kiss, John D. Graef, Eric Shields, Linda J. Bristow, Jean Simmermacher, Rick L. Pieschl, Fu-ni Luan, Eric Schaeffer, David Luchetti, Yu-Wen Li
Publikováno v:
Brain research. 1609
The long lasting antidepressant response seen following acute, i.v. ketamine administration in patients with treatment-resistant depression (TRD) is thought to result from enhanced synaptic plasticity in cortical and hippocampal circuits. Using extra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606eb3e88a058dd79f9c084ae96106dd
https://pubmed.ncbi.nlm.nih.gov/25796435
https://pubmed.ncbi.nlm.nih.gov/25796435