Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kimberli J. Kamer"'
Autor:
Xiang Li, Mahboubeh Kheirabadi, Patrick G. Dougherty, Kimberli J. Kamer, Xiulong Shen, Nelsa L. Estrella, Suresh Peddigari, Anushree Pathak, Sara L. Blake, Emmanuelle Sizensky, Carmen del Genio, Arti B. Gaur, Mohanraj Dhanabal, Mahasweta Girgenrath, Natarajan Sethuraman, Ziqing Qian
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 273-285 (2023)
Biological therapeutic agents are highly targeted and potent but limited in their ability to reach intracellular targets. These limitations often necessitate high therapeutic doses and can be associated with less-than-optimal therapeutic activity. On
Externí odkaz:
https://doaj.org/article/c545362a9b934efa93a2eb6bb193eec3
Autor:
David G. Nicholls, Anya Wernersson, Vamsi K. Mootha, Peter Spégel, Kimberli J. Kamer, H. Barnard, Elaine Cowan, Neelanjan Vishnu, Annika Bagge, Alexander Hamilton, Malin Fex, Anders Tengholm, Hindrik Mulder, Y. Sancak
Publikováno v:
Molecular Metabolism, Vol 51, Iss, Pp 101239-(2021)
Molecular Metabolism
Molecular Metabolism
Objective Transport of Ca2+ into pancreatic β cell mitochondria facilitates nutrient-mediated insulin secretion. However, the underlying mechanism is unclear. Recent establishment of the molecular identity of the mitochondrial Ca2+ uniporter (MCU) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896292a8a6b0f86d39660eb55ca5d9ff
http://www.sciencedirect.com/science/article/pii/S2212877821000843
http://www.sciencedirect.com/science/article/pii/S2212877821000843
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3546-3555
The mitochondrial uniporter is a Ca 2+ -channel complex resident within the organelle’s inner membrane. In mammalian cells the uniporter’s activity is regulated by Ca 2+ due to concerted action of MICU1 and MICU2, two paralogous, but functionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e1e8ee366a2cbdfaaf491b76902cea
https://doi.org/10.1073/pnas.1817759116
https://doi.org/10.1073/pnas.1817759116
Autor:
Molly Plovanich, Roman L Bogorad, Yasemin Sancak, Kimberli J Kamer, Laura Strittmatter, Andrew A Li, Hany S Girgis, Satya Kuchimanchi, Jack De Groot, Lauren Speciner, Nathan Taneja, Jonathan Oshea, Victor Koteliansky, Vamsi K Mootha
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55785 (2013)
Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter th
Externí odkaz:
https://doaj.org/article/a7337a4d9d914019b479cff21e32b7e5
Publikováno v:
EMBO reports. 18:1397-1411
The mitochondrial calcium uniporter is a Ca 2+ ‐activated Ca 2+ channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca 2+ signals. It is regulated by two paralogous EF‐hand proteins—MICU1 and MICU2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4bc3e7b1441d4ccd37b011e71a4cf51
https://doi.org/10.15252/embr.201643748
https://doi.org/10.15252/embr.201643748
Autor:
Vamsi K. Mootha, Olivier Julien, Karl R. Clauser, Sarah E. Calvo, James A. Wells, Kimberli J. Kamer, Hongying Shen
Publikováno v:
Molecular & Cellular Proteomics. 16:512-523
The majority of mitochondrial proteins are encoded in the nuclear genome, translated in the cytoplasm, and directed to the mitochondria by an N-terminal presequence that is cleaved upon import. Recently, N-proteome catalogs have been generated for mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f846b4b6cf66623e65eae175a375ce
https://doi.org/10.1074/mcp.m116.063818
https://doi.org/10.1074/mcp.m116.063818
Autor:
Kimberli J. Kamer, Alexander Hamilton, Anders Tengholm, Annika Bagge, Anya Wernersson, Hindrik Mulder, Neelanjan Vishnu, David G. Nicholls, Malin Fex, H. Barnard, Peter Spégel, Elaine Cowan, Y. Sancak, Vamsi K. Mootha
SUMMARYTransport of Ca2+from the cytosol to the mitochondrial matrix of insulin-secreting pancreatic β-cells facilitates nutrient-mediated insulin secretion. However, the underlying mechanism is unclear. The establishment of the molecular identity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c618e137a14287998101dd6644877a4b
Autor:
Kimberli J, Kamer, Yasemin, Sancak, Yevgenia, Fomina, Joshua D, Meisel, Dipayan, Chaudhuri, Zenon, Grabarek, Vamsi K, Mootha
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(34)
The mitochondrial uniporter is a Ca(2+)-activated Ca(2+) channel complex that displays exceptionally high conductance and selectivity. Here, we report cellular metal toxicity screens highlighting the uniporter’s role in Mn(2+) toxicity. Cells lacki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b5ab3a8565e7cff7d030610a9748bd3
https://pubmed.ncbi.nlm.nih.gov/30082385
https://pubmed.ncbi.nlm.nih.gov/30082385
Autor:
Dipayan Chaudhuri, Vamsi K. Mootha, Yasemin Sancak, Yevgenia Fomina, Joshua D. Meisel, Zenon Grabarek, Kimberli J. Kamer
Publikováno v:
Proceedings of the National Academy of Sciences. 115
The mitochondrial uniporter is a Ca2+-activated Ca2+ channel complex that displays exceptionally high conductance and selectivity. Here, we report cellular metal toxicity screens highlighting the uniporter’s role in Mn2+ toxicity. Cells lacking the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f37e65ec51ae21727766b150f726bf6f
https://doi.org/10.1073/pnas.1807811115
https://doi.org/10.1073/pnas.1807811115
Autor:
Tawfeg Ben-Omran, Nawal Makhseed, Mariam Almureikhi, Kimberli J. Kamer, Fatma Al Mesaifri, Sara Musa, Noora Shahbeck, Rehab Ali, Wafaa Ali AlShehhi, Zakkiriah Mohamed, Jane Juusola, Vamsi K. Mootha, Wafaa Eyaid
Publikováno v:
JIMD Reports ISBN: 9783662586136
MICU1 encodes a Ca2+ sensing, regulatory subunit of the mitochondrial uniporter, a selective calcium channel within the organelle’s inner membrane. Ca2+ entry into mitochondria helps to buffer cytosolic Ca2+ transients and also activates ATP produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98c33b17cf4e8009fa9ec86a65f0f2f5
https://doi.org/10.1007/8904_2018_107
https://doi.org/10.1007/8904_2018_107