Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kimberley El"'
Autor:
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O’Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) signaling is critical in GIP-based therapeutics’ ability to lower body weight, but pathways leveraged by GIPR pharmacology in the brain remain incompletely understood. We ex
Externí odkaz:
https://doaj.org/article/98622c9a195d4352900a24be2e5b4bd3
Autor:
Bin Yang, Vasily M. Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Barent DuBois, Ann Maria Kruse Hansen, Diego Perez-Tilve, Patrick J. Knerr, David D'Alessio, Jonathan E. Campbell, Jonathan D. Douros, Brian Finan
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101638- (2022)
Objective: Glucose-dependent insulinotropic polypeptide (GIP) is one of the two major incretin factors that regulate metabolic homeostasis. Genetic ablation of its receptor (GIPR) in mice confers protection against diet-induced obesity (DIO), while G
Externí odkaz:
https://doaj.org/article/5be25854491f46ddb6f40e6afecdb0ce
Akademický článek
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Type 1 Diabetes (T1D) is caused by autoimmune-mediated beta cell destruction. Following beta cell injury, the pancreas attempts to launch a cellular repair and regenerative program, yet it fails to completely restore functional beta cell mass. One co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a02823c2024fa0156599373541449faf
https://doi.org/10.1101/2023.01.30.526325
https://doi.org/10.1101/2023.01.30.526325
Autor:
Suneet Kaur, Badr Sokrat, Megan E. Capozzi, Kimberley El, Yushi Bai, Aeva Jazic, Bridgette Han, Kaavya Krishna Kumar, David A. D'Alessio, Jonathan E. Campbell, Michel Bouvier, Sudha K. Shenoy
Publikováno v:
Journal of Biological Chemistry. 299:104690
Autor:
Kimberley El, Kyle W. Sloop, Derek J. Nunez, J. L. Brown, Megan E. Capozzi, Jonathan E. Campbell, Sara E. Encisco, Bryanna M. Chazotte, A. Clifford, Berit Svendsen, Sarah M. Gray, Matthew J. Merrins, E. R. Knuth, E. Jin, David A. D'Alessio
Publikováno v:
Science Advances
GIPR activity in α cells is required for the complete metabolic response to a meal.
Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP
Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP
Autor:
Femke Christina Ching-Chuan van Rhijn-Brouwer, Kimberley Elaine Wever, Romy Kiffen, Jon-Ruben van Rhijn, Hendrik Gremmels, Joost Ougust Fledderus, Robin Wilhelmus Maria Vernooij, Marianne Christina Verhaar
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/509249206fd742eea6e38faf60d61c35
Publikováno v:
Endocrinology
Glucose homeostasis is maintained in large part due to the actions of the pancreatic islet hormones insulin and glucagon, secreted from β- and α-cells, respectively. The historical narrative positions these hormones in opposition, with insulin prim
Autor:
Yurong Xin, Sarah M. Gray, David A. D'Alessio, Megan E. Capozzi, Elizabeth C. Ross, Kimberley El, Berit Svendsen, Jenny Tong, Jesper Gromada, Peter Ravn, Jonathan E. Campbell, Bryanna M. Chazotte, Kyle W. Sloop
Publikováno v:
J Biol Chem
The insulinotropic actions of glucagon-like peptide 1 receptor (GLP-1R) in β-cells have made it a useful target to manage type 2 diabetes. Metabolic stress reduces β-cell sensitivity to GLP-1, yet the underlying mechanisms are unknown. We hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04f12e4515a1de02b8be69f5bfd768d
https://europepmc.org/articles/PMC7450118/
https://europepmc.org/articles/PMC7450118/
Autor:
Kimberley El, Paul Emmerson, David A. D'Alessio, Kyle W. Sloop, Jennifer L. Brown, Megan Capozzi, Sarah M. Gray, Francis S. Willard, Jonathan Campbell
Publikováno v:
Diabetes. 69
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are the principal incretins connecting nutrient intake to postprandial insulin secretion. Both GIP and GLP-1 directly stimulate insulin secretion in β-cells throu