Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kimberley A. Treinen"'
Autor:
Raviprakash R. Dugyala, Barry S. McIntyre, Ronald D. Snyder, Kimberley A. Treinen, Robert Veneziale, Yi‐Zhong Gu, Leslie A. Obert, Brian P. Enright
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89:474-484
BACKGROUND: The effects of histamine H1 antagonist chlorcyclizine on rat palate development were characterized following in utero exposure. METHODS: To identify the optimum dose for inducing cleft palate, pregnant rats were administered 30, 60, or 90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1304b85e6b04839c08eb470926aad416
https://doi.org/10.1002/bdrb.20261
https://doi.org/10.1002/bdrb.20261
Autor:
Kimberley A. Treinen, Stephan J. Kopytek, Evan A. Thackaberry, Barry S. McIntyre, Brian P. Enright
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 89:504-516
BACKGROUND: A series of studies were conducted to assess Polysorbate 80 (PS80), Propylene Glycol (PG), and Hydroxypropyl-β-Cyclodextrin (HPβCD), when compared with Hydroxypropyl Methylcellulose (MC) in developmental and reproductive toxicology (DAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0298b80d83b89b790e486bacd1f331b6
https://doi.org/10.1002/bdrb.20273
https://doi.org/10.1002/bdrb.20273
Autor:
Daniel C. Maneval, Christopher M. Bral, Zoe Chen, Kimberley A. Treinen, Irwin Y. Rosenblum, Mark E. Cartwright, Robert W. Veneziale, Joseph C. Arezzo, Dinesh P. Sinha, Xiao Yan Cai, Barbara Faha, Joyce Nelson, Robert J. Munger, Robert W. Watkins, Constance Cullen, Narendra S. Kishnani
Publikováno v:
Cutaneous and Ocular Toxicology. 26:83-105
Monkey studies were conducted for the preclinical safety assessment of SCH 412499, an adenovirus encoding p21, administered by subconjunctival injection prior to trabeculectomy for postoperative maintenance of the surgical opening. Biodistribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70eb2c7ff7aba0ce68b1be35413bfde9
https://doi.org/10.1080/15569520701212167
https://doi.org/10.1080/15569520701212167
Autor:
Thomas F.X. Collins, Ronald H. Gray, R. Woodrow Setzer, Ulrike Luderer, Kimberley A. Treinen, George P. Daston, Andrew F. Olshan, Roel Vermeulen, Franklin E. Mirer, Lawrence J. Fischer
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 77:110-193
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7960241f268751e5981f8c9a6e1bad2d
https://doi.org/10.1002/bdrb.20061
https://doi.org/10.1002/bdrb.20061
Publikováno v:
Reproductive Toxicology. 17:691-697
Normal pre- and postnatal male reproductive development and function is dependent upon testicular androgen production and is sensitive to antiandrogenic perturbations. It was of interest to determine if the H(1) histamine antagonist loratadine had th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46891c0556e52099574df1629d54bfe3
https://doi.org/10.1016/s0890-6238(03)00108-4
https://doi.org/10.1016/s0890-6238(03)00108-4
Publikováno v:
Toxicological Sciences. 41:199-207
Idoxifene, a tissue-specific selective estrogen receptor modulator, was evaluated in male and female rats and female rabbits after oral administration for effects on fertility and/or embryo–fetal development. In all studies, adult toxicity was evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3019deb9dfe6a6e0fb86ec04e096b9c
https://doi.org/10.1093/toxsci/41.2.199
https://doi.org/10.1093/toxsci/41.2.199
Publikováno v:
Toxicological Sciences. 33:11-15
Mangafodipir trisodium injection (MnDPDP) is an intravenously administered manganese chelate undergoing clinical evaluation for magnetic resonance imaging contrast enhancement of the hepatobiliary system. The anticipated single clinical dose for adul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b497b726e4cd013fd0ac8fbfc1404480
https://doi.org/10.1093/toxsci/33.1.11
https://doi.org/10.1093/toxsci/33.1.11
Publikováno v:
Teratology. 52:109-115
Mangafodipir trisodium (MnDPDP) is a manganese chelate being developed as a contrast agent for magnetic resonance imaging of the hepatobiliary system. The intended clinical dose is 5 mumol/kg. The potential for MnDPDP to induce embryotoxicity and/or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3be26e0d04fa91beeb9b3d180309f80
https://doi.org/10.1002/tera.1420520207
https://doi.org/10.1002/tera.1420520207
Autor:
Stephan J. Kopytek, Stephen A. Barat, Kimberley A. Treinen, Brian P. Enright, Barry S. McIntyre
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 95(1)
BACKGROUND SCH 486757 is a nociceptin-1 receptor agonist that was in development as an antitussive. Studies were conducted to characterize its effects on female fertility and to examine its potential modes of action. METHODS Female rats were administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bffa190f4ff3496a29143da9055a88b
https://pubmed.ncbi.nlm.nih.gov/21922640
https://pubmed.ncbi.nlm.nih.gov/21922640
Autor:
Kimberley A. Treinen, Robert E. Chapin
Publikováno v:
Toxicology and Applied Pharmacology. 107:325-335
Boric acid is an inorganic acid that impairs fertility in male rodents. A reproductive assessment by continuous breeding study found that male rats treated with boric acid had decreased fertility and sperm motility. In order to determine the cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e28553124de73f32d003ff69e80ab2
https://doi.org/10.1016/0041-008x(91)90212-w
https://doi.org/10.1016/0041-008x(91)90212-w