Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Kimball SD"'
Autor:
Raj N. Misra, William G. Humphreys, K R Webster, John S. Sack, Y. F. Kelly, Janet G. Mulheron, Kimball Sd, Ligang Qian, Sam T. Chao, Kyoung S. Kim, Leslie Leith, John T. Hunt, Barri Wautlet, John S. Tokarski
Publikováno v:
Journal of Medicinal Chemistry. 43:4126-4134
Flavopiridol analogues, thio- and oxoflavopiridols which contain a sulfur (16) or oxygen (18) atom linker between a chromone ring and the hydrophobic side chain, are selective cyclin-dependent kinase 1 (CDK1) inhibitors with an IC(50) of 110 and 130
Autor:
Mary F. Malley, B. C. O'reilly, K. S. Atwal, J. Schwartz, Jack Z. Gougoutas, Kimball Sd, Suzanne Moreland, G. C. Rovnyak, Anders Hedberg
Publikováno v:
ChemInform. 24
Autor:
Jagabandhu Das, G. C. Rovnyak, Ving G. Lee, Chester F. Turk, David M. Floyd, Kimball Sd, Duff Kj, Robert V. Moquin, John Krapcho, John T. Hunt
Publikováno v:
Journal of Medicinal Chemistry. 35:780-793
We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the pr
Autor:
Richard A. Morrison, Wen-Ching Han, Ronald E. White, Ping Chen, Jagabandhu Das, R. Gedamke, Kimball Sd, Robert V. Moquin, Mary T. Obermeier, William G. Humphreys, S. Chong
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 33(1)
1. The disposition of acyl prodrugs was studied to improve the delivery of a guanidine-containing parent compound with poor membrane permeability and poor absorption. 2. The prodrugs were evaluated in vitro and in vivo for conversion to drug. Prodrug
Autor:
G. C. Rovnyak, Jack Z. Gougoutas, Anders Hedberg, G Cucinotta, John D. Dimarco, B Beyer, Mary F. Malley, J P McCarthy, Kimball Sd, Rongan Zhang
Publikováno v:
Journal of medicinal chemistry. 38(1)
Dihydropyrimidines 4, 6, and 15, uniquely designed to unambiguously establish structural and conformational determinants for DHP receptor occupation and for modulation of calcium channel function, were prepared and examined for calcium channel modula
Autor:
Brian C. O'Reilly, Suzanne Moreland, Jack Z. Gougoutas, Karnail Atwal, Anders Hedberg, Kimball Sd, Joseph Schwartz, Mary F. Malley, G. C. Rovnyak
Publikováno v:
Journal of medicinal chemistry. 35(17)
We have examined a series of novel dihydropyrimidine calcium channel blockers that contain a basic group attached to either C5 or N3 of the heterocyclic ring. Structure-activity studies show that a 1-(phenylmethyl)-4-piperidinyl carbamate moiety at N
Autor:
Kimball Sd, Jagabandhu Das, Mary T. Obermeier, Ridgewell Re, David M. Floyd, Suzanne Moreland, White Re, Michael W. Lago, Duff Kj, John Krapcho
Publikováno v:
Journal of medicinal chemistry. 35(14)
We have shown that the pyrrolidinylmethyl substituent on the lactam nitrogen (N1) of benzazepinone and benzothiazepinone calcium channel blocking agents is resistant to metabolic deamination and generally increases the duration and potency of antihyp
Autor:
Jagabandhu Das, Jack Z. Gougoutas, Vu Tc, Robert V. Moquin, Mary F. Malley, Ving G. Lee, Michael W. Lago, Kimball Sd, Duff Kj, David M. Floyd
Publikováno v:
Journal of medicinal chemistry. 35(4)
As part of a program aimed at identifying novel analogues of diltiazem, we developed several synthetic routes for 3-alkylbenzazepinones, both in racemic and nonracemic form. Structure-activity relationship studies in this series have led to identific
Autor:
Jack Z. Gougoutas, Andrew T. Pudzianowski, Suzanne Moreland, G. C. Rovnyak, Niels H. Andersen, Mary F. Malley, Anders Hedberg, Kimball Sd, M Porubcan
Publikováno v:
Journal of medicinal chemistry. 34(8)
The conformational requisites at the receptor for unsymmetrically substituted phenyl-1,4-dihydropyridine calcium entry blockers are examined by screening a series of (2'-halophenyl)-1,4-dihydropyridines 1-4, with increasing bulk at the 2'-position of
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.