Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Kimba L. Ashworth"'
Autor:
Peter F. Bousquet, Daniel H. Albert, Gary A. Gintant, Patrick A. Marcotte, Gilbert Diaz, George A. Cunha, Ruth L. Martin, Kathryn Houseman, Stevan W. Djuric, Jürgen Dinges, Jennifer J. Bouska, Thomas J. Sowin, Paul Tapang, Charles W. Hutchins, Michael R. Michaelides, Kimba L. Ashworth, Eric F. Johnson, Henry Q. Zhang, Irini Akritopoulou-Zanze, Michelle Nyein, Arnold Lee D, Hu Li, Steven K. Davidsen, Alan F. Gasiecki, Christopher M. Harris, Vijaya Gracias, Zhi Su, Zhiren Xia
Publikováno v:
Journal of Medicinal Chemistry. 50:2011-2029
The synthesis of a novel series of 1,4-dihydroindeno[1,2-c]pyrazoles with acetylene-type side chains is described. Optimization of those compounds as KDR kinase inhibitors identified 8, which displayed an oral activity in an estradiol-induced murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7224e585fce7d1645dd21a1f5e3e55
https://doi.org/10.1021/jm061223o
https://doi.org/10.1021/jm061223o
Autor:
Jürgen, Dinges, Kimba L, Ashworth, Irini, Akritopoulou-Zanze, Irini, Akritopolou-Zanze, Lee D, Arnold, Steven A, Baumeister, Peter F, Bousquet, George A, Cunha, Steven K, Davidsen, Stevan W, Djuric, Vijaya J, Gracias, Michael R, Michaelides, Paul, Rafferty, Thomas J, Sowin, Kent D, Stewart, Zhiren, Xia, Henry Q, Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4266-4271
A series of 1,4-dihydroindeno[1,2-c]pyrazoles with a 3-thiophene substituent carrying a urea-type side chain were identified as potent multitargeted (VEGFR and PDGFR families) receptor tyrosine kinase inhibitors. A KDR homology model suggested that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28684c9797329826d7cfb032e78b7827
https://doi.org/10.1016/j.bmcl.2006.05.066
https://doi.org/10.1016/j.bmcl.2006.05.066
Autor:
Steven K. Davidsen, George A. Cunha, Henry Q. Zhang, Jürgen Dinges, Michael R. Michaelides, Lee D. Arnold, Vijaya Gracias, Zhiren Xia, Peter F. Bousquet, Paul Rafferty, Stevan W. Djuric, Steven A. Baumeister, Kent D. Stewart, Irini Akritopoulou-Zanze, Thomas J. Sowin, Kimba L. Ashworth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3516
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1901913aa21b31cb30db679e0630cf
https://doi.org/10.1016/j.bmcl.2007.05.001
https://doi.org/10.1016/j.bmcl.2007.05.001
Autor:
Jürgen Dinges, Daniel H. Albert, Lee D. Arnold, Kimba L. Ashworth, Irini Akritopoulou-Zanze, Peter F. Bousquet, Jennifer J. Bouska, George A. Cunha, Steven K. Davidsen, Gilbert J. Diaz, Stevan W. Djuric, Alan F. Gasiecki, Gary A. Gintant, Vijaya J. Gracias, Christopher M. Harris, Kathryn A. Houseman, Charles W. Hutchins, Eric F. Johnson, Hu Li, Patrick A. Marcotte
Publikováno v:
Journal of Medicinal Chemistry; May2007, Vol. 50 Issue 9, p2011-2029, 19p