Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Kimal, Rajapakshe"'
Autor:
Marco Napoli, Sarah J. Wu, Bethanie L. Gore, Hussein Abbas, Kyubum Lee, Rahul Checker, Shilpa Dhar, Kimal Rajapakshe, Aik Choon Tan, Min Gyu Lee, Cristian Coarfa, Elsa R. Flores
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The mechanistic role regulated by the oncogene ∆Np63 in lung cancer development is currently unclear. Here, the authors show that ΔNp63 is pro-tumorigenic in lung adenocarcinoma as well as squamous cell carcinoma, and maintains lung cancer progeni
Externí odkaz:
https://doaj.org/article/a54ffb2bed5c4674b91dd20aff90866c
Autor:
Gianfranco Matrone, Sung Yun Jung, Jong Min Choi, Antrix Jain, Hon-Chiu Eastwood Leung, Kimal Rajapakshe, Cristian Coarfa, Julie Rodor, Martin A. Denvir, Andrew H. Baker, John P. Cooke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The role of the post-translational modifications in tissue regeneration is still not clearly understood. Here, the authors show that many nuclear proteins change S-nitrosylation state in the regenerating zebrafish tailfin, highlighting the importance
Externí odkaz:
https://doaj.org/article/adfe028e44264c2b8db2eceb6959bc23
Autor:
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Cristian Coarfa, Kimal Rajapakshe, Dimuthu Perera, Jizhong Cheng, Huaizhu Wu, Christie M. Ballantyne, Zheng Sun, Liang Xie, Xinchun Pi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The vascular endothelium contributes to metabolic regulation, however, the underlying mechanisms are not fully understood. Here the authors show that endothelial low-density lipoprotein receptor-related protein 1 regulates glucose homeostasis via ost
Externí odkaz:
https://doaj.org/article/2bb6c637cb5f4e2eb55a2f359b4beb74
Autor:
Brittany A. Stork, Adam Dean, Andrea R. Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D. Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L. Lorenzi, Bruce E. Kemp, Benjamin E. Turk, John W. Scott, Anthony R. Means, Brian York
Publikováno v:
Molecular Metabolism, Vol 62, Iss , Pp 101513- (2022)
Objective: The liver is the primary internal metabolic organ that coordinates whole body energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological inhibition of calcium/calmodulin-dependent protein kinase kinase 2 (Ca
Externí odkaz:
https://doaj.org/article/3fe4f2f2b8c740fa9ee651656cb3b479
Autor:
Marco Napoli, Xiaobo Li, Hayley D. Ackerman, Avani A. Deshpande, Ivan Barannikov, Marlese A. Pisegna, Isabelle Bedrosian, Jürgen Mitsch, Philip Quinlan, Alastair Thompson, Kimal Rajapakshe, Cristian Coarfa, Preethi H. Gunaratne, Douglas C. Marchion, Anthony M. Magliocco, Kenneth Y. Tsai, Elsa R. Flores
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Mutations in TP53 and hyperactivation of the PI3K/AKT pathway are the two most frequent drivers of cancer progression across multiple human tumour types. Here, the authors identify two TAp63 regulated long non-coding RNAs, TROLL-2 and TROLL-3, that c
Externí odkaz:
https://doaj.org/article/54b1981e95054652a2e282a7299606ef
Autor:
Meenu Sharma, Hiep Khong, Faisal Fa’ak, Salah-Eddine Bentebibel, Louise M. E. Janssen, Brent C. Chesson, Caitlin A. Creasy, Marie-Andrée Forget, Laura Maria S. Kahn, Barbara Pazdrak, Binisha Karki, Yared Hailemichael, Manisha Singh, Christina Vianden, Srinivas Vennam, Uddalak Bharadwaj, David J. Tweardy, Cara Haymaker, Chantale Bernatchez, Shixia Huang, Kimal Rajapakshe, Cristian Coarfa, Michael E. Hurwitz, Mario Sznol, Patrick Hwu, Ute Hoch, Murali Addepalli, Deborah H. Charych, Jonathan Zalevsky, Adi Diab, Willem W. Overwijk
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Interleukin-2 can induce an anti-tumour response, but is associated with toxicity. Here, the authors demonstrate that an engineered interleukin-2 promotes intratumoral T regulatory cell depletion while enhancing effective anti-tumour CD8+ T cell resp
Externí odkaz:
https://doaj.org/article/ef1801862b2840b0a440db03c657db66
ISA101 and nivolumab for HPV-16+ cancer: updated clinical efficacy and immune correlates of response
Autor:
Jing Wang, Lei Feng, Qi Wang, Erminia Massarelli, Renata Ferrarotto, Michael A Curran, Jack Lee, Ignacio Wistuba, Cornelis J M Melief, Bonnie S Glisson, Kimal Rajapakshe, Cristian Coarfa, William William, Luana Guimaraes de Sousa, Jaime Rodriguez Canales, Renee L Chin, Tomas Z Barrese, Faye M Johnson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Background The combination of ISA101, a human papilloma virus (HPV) 16 peptide vaccine, and nivolumab showed a promising response rate of 33% in patients with incurable HPV-16+ cancer. Here we report long-term clinical outcomes and immune correlates
Externí odkaz:
https://doaj.org/article/34f47116ff354f21a698a6dbad44cf29
Autor:
Michael Curran, Chao-Hsien Chen, Qinying Liu, Kimal Rajapakshe, Cristian Coarfa, Anupallavi Srinivasamani, Shwetha Hegde
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/8fc6dfde9c1d4c5699a6659c9c18bed2
Autor:
Casey Ager, Michael Curran, Philip Jones, Akash Boda, Kimal Rajapakshe, Spencer Lea, Maria Emilia Di Francesco
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/a8c57b4098cb4bf187b61852eb7e7973
Autor:
Michael A Curran, Casey R Ager, Philip Jones, Akash Boda, Kimal Rajapakshe, Spencer Thomas Lea, Maria Emilia Di Francesco, Priyamvada Jayaprakash, Ravaen B Slay, Brittany Morrow, Rishika Prasad, Meghan A Dean, Colm R Duffy, Cristian Coarfa
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background Intratumoral injection of cyclic dinucleotide (CDN) agonists of the stimulator of interferon genes (STING) pathway engages innate immune activation and priming of adaptive immune effectors to foster local and distal tumor clearance. Despit
Externí odkaz:
https://doaj.org/article/d0f57e0df0f34deebce56caf111fe5d1