Efficient prime editing in two-cell mouse embryos using PEmbryo.

Autor: Kim-Yip RP; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., McNulty R; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Joyce B; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Mollica A; Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Chen PJ; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.; Prime Medicine, Inc., Cambridge, MA, USA., Ravisankar P; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Law BK; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Toettcher JE; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Ivakine EA; Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Posfai E; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. eposfai@princeton.edu., Adamson B; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. badamson@princeton.edu.; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA. badamson@princeton.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Feb 06. Date of Electronic Publication: 2024 Feb 06.

Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal.

Autor: Kim-Yip RP; Center for Reproductive Sciences, Departments of Anatomy and OB/GYN-RS, University of California, San Francisco, CA 94143-0452, USA., Nystul TG; Center for Reproductive Sciences, Departments of Anatomy and OB/GYN-RS, University of California, San Francisco, CA 94143-0452, USA todd.nystul@ucsf.edu.

Publikováno v: Development (Cambridge, England) [Development] 2018 Dec 05; Vol. 145 (23). Date of Electronic Publication: 2018 Dec 05.