Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kim Zarse"'
Autor:
Carolin Thomas, Reto Erni, Jia Yee Wu, Fabian Fischer, Greta Lamers, Giovanna Grigolon, Sarah J. Mitchell, Kim Zarse, Erick M. Carreira, Michael Ristow
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract To ameliorate or even prevent signatures of aging in ultimately humans, we here report the identification of a previously undescribed polyacetylene contained in the root of carrots (Daucus carota), hereafter named isofalcarintriol, which we
Externí odkaz:
https://doaj.org/article/816cfe15ca7a4de49c80b72c8c28c860
Autor:
Doruntina Bresilla, Hansjoerg Habisch, Iva Pritišanac, Kim Zarse, Warisara Parichatikanond, Michael Ristow, Tobias Madl, Corina T. Madreiter-Sokolowski
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Due to intact reactive oxygen species homeostasis and glucose metabolism, C57BL/6NRj mice are especially suitable to study cellular alterations in metabolism. We applied Nuclear Magnetic resonance spectroscopy to analyze five different tissu
Externí odkaz:
https://doaj.org/article/7444a2211d2f43c883a78096d298a36a
Autor:
Giovanna Grigolon, Elisa Araldi, Reto Erni, Jia Yee Wu, Carolin Thomas, Marco La Fortezza, Beate Laube, Doris Pöhlmann, Markus Stoffel, Kim Zarse, Erick M. Carreira, Michael Ristow, Fabian Fischer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Life- and healthspan of organisms can be modulated by dietary, genetic, or pharmacological interventions, which often affect metabolic pathways. Here the authors report that Grainyhead 1 is an evolutionarily conserved, drug-inducible transcription fa
Externí odkaz:
https://doaj.org/article/cb59d5e7eada454092055d343fa39584
Autor:
Chiara Musillo, Letizia Giona, Michael Ristow, Kim Zarse, Karsten Siems, Alessia Di Francesco, Barbara Collacchi, Carla Raggi, Francesca Cirulli, Alessandra Berry
Publikováno v:
Nutrients, Vol 15, Iss 15, p 3366 (2023)
A growing body of evidence suggests that regular consumption of natural products might promote healthy aging; however, their mechanisms of action are still unclear. Rosmarinic acid (RA) is a polyphenol holding anti-inflammatory, antioxidant and neuro
Externí odkaz:
https://doaj.org/article/b72bd22ef3c9417399dd394e1d54f802
Autor:
Troy L. Merry, Chris P. Hedges, Stewart W. Masson, Beate Laube, Doris Pöhlmann, Stephan Wueest, Michael E. Walsh, Myrtha Arnold, Wolfgang Langhans, Daniel Konrad, Kim Zarse, Michael Ristow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Hyper-insulinemia associated with excess calorie intake may cause metabolic dysfunction. Here the authors report that mice with partially reduced insulin receptor expression in peripheral tissues are protected from and experience reversal of fatty li
Externí odkaz:
https://doaj.org/article/3f677e3dd7d8427a94a17c5f51b1a7b5
Autor:
Leonid Rozanov, Meenakshi Ravichandran, Giovanna Grigolon, Maria Clara Zanellati, Johannes Mansfeld, Kim Zarse, Nir Barzilai, Gil Atzmon, Fabian Fischer, Michael Ristow
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
Physiological aging is a complex process, influenced by a plethora of genetic and environmental factors. While being far from fully understood, a number of common aging hallmarks have been elucidated in recent years. Among these, transcriptomic alter
Externí odkaz:
https://doaj.org/article/7266385a6a5d43b1a6621649e21a4cdc
Autor:
Troy L. Merry, Chris P. Hedges, Stewart W. Masson, Beate Laube, Doris Pöhlmann, Stephan Wueest, Michael E. Walsh, Myrtha Arnold, Wolfgang Langhans, Daniel Konrad, Kim Zarse, Michael Ristow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/fe1ab036bcc64b3e9e1f297620bff69a
Autor:
Misa Hirose, Paul Schilf, Kim Zarse, Hauke Busch, Georg Fuellen, Olaf Jöhren, Rüdiger Köhling, Inke R. König, Barbara Richer, Jan Rupp, Markus Schwaninger, Karsten Seeger, Christian Sina, Michael Ristow, Saleh M. Ibrahim
Publikováno v:
Genes, Vol 10, Iss 7, p 532 (2019)
Mitochondrial complex I—the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery—has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting p
Externí odkaz:
https://doaj.org/article/0589b49b8a25435aab07f5330fbab6c3
Autor:
Steffen Priebe, Uwe Menzel, Kim Zarse, Marco Groth, Matthias Platzer, Michael Ristow, Reinhard Guthke
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77776 (2013)
Glucose restriction mimicked by feeding the roundworm Caenorhabditis elegans with 2-deoxy-D-glucose (DOG) - a glucose molecule that lacks the ability to undergo glycolysis - has been found to increase the life span of the nematodes considerably. To f
Externí odkaz:
https://doaj.org/article/887ca5221a8547eda386e9fdf3f64806
Autor:
Kim Zarse, Michael Ristow
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e4062 (2008)
It was recently suggested that specific antidepressants of the serotonin-antagonist type, namely mianserin and methiothepin, may exert anti-aging properties and specifically extend lifespan of the nematode C.elegans by causing a state of perceived ca
Externí odkaz:
https://doaj.org/article/b3bad61f623e411ea1eb633c3b8f9c76