Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Kim Van Vliet"'
Autor:
Dan Wang, Shaoyong Li, Dominic J. Gessler, Jun Xie, Li Zhong, Jia Li, Karen Tran, Kim Van Vliet, Lingzhi Ren, Qin Su, Ran He, Jason E. Goetzmann, Terence R. Flotte, Mavis Agbandje-McKenna, Guangping Gao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 234-246 (2018)
Adeno-associated virus (AAV) has provided the gene therapy field with the most powerful in vivo gene delivery vector to realize safe, efficacious, and sustainable therapeutic gene expression. Because many clinically relevant properties of AAV-based v
Externí odkaz:
https://doaj.org/article/2cc5779e721144d889d5f82d48f8b7d8
Autor:
Kim Van Vliet, Claybourne Moore
Publikováno v:
Journal of Microbiology & Biology Education, Vol 17, Iss 1, Pp 13-16 (2016)
The Internet and smart phone technologies have opened up new avenues for collaboration among scientists around the world. These technologies have also expanded citizen science opportunities and public participation in scientific research (PPSR). Here
Externí odkaz:
https://doaj.org/article/b3527886db774cd38d700f781f0ef322
Autor:
Bridget Lins-Austin, Saajan Patel, Mario Mietzsch, Dewey Brooke, Antonette Bennett, Balasubramanian Venkatakrishnan, Kim Van Vliet, Adam N. Smith, Joanna R. Long, Robert McKenna, Mark Potter, Barry Byrne, Sanford L. Boye, Brian Bothner, Regine Heilbronn, Mavis Agbandje-McKenna
Publikováno v:
Viruses, Vol 12, Iss 6, p 668 (2020)
Adeno-associated viruses (AAVs) are small, non-pathogenic ssDNA viruses being used as therapeutic gene delivery vectors for the treatment of a variety of monogenic diseases. An obstacle to successful gene delivery is inefficient capsid trafficking th
Externí odkaz:
https://doaj.org/article/c53fc790c6d747268e96cc1198cbcd18
Autor:
Mark Potter, Bridget Lins, Mario Mietzsch, Regine Heilbronn, Kim Van Vliet, Paul Chipman, Mavis Agbandje-McKenna, Brian D Cleaver, Nathalie Clément, Barry J Byrne, Sergei Zolotukhin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
We describe a new rapid, low cost, and scalable method for purification of various recombinant adeno-associated viruses (rAAVs) from the lysates of producer cells of either mammalian or insect origin. The method takes advantage of two general biochem
Externí odkaz:
https://doaj.org/article/c17f51f63f434046bfc638662e57c782
Autor:
Christine N Kay, Renee C Ryals, George V Aslanidi, Seok Hong Min, Qing Ruan, Jingfen Sun, Frank M Dyka, Daniel Kasuga, Andrea E Ayala, Kim Van Vliet, Mavis Agbandje-McKenna, William W Hauswirth, Sanford L Boye, Shannon E Boye
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62097 (2013)
Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transd
Externí odkaz:
https://doaj.org/article/acb82117f6a642269cce77147bb4a790
Autor:
Joseph Tellez, Kim Van Vliet, Yu-Shan Tseng, Jonathan D Finn, Nick Tschernia, Graça Almeida-Porada, Valder R Arruda, Mavis Agbandje-McKenna, Christopher D Porada
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75142 (2013)
AAV vectors have shown great promise for clinical gene therapy (GT), but pre-existing human immunity against the AAV capsid often limits transduction. Thus, testing promising AAV-based GT approaches in an animal model with similar pre-existing immuni
Externí odkaz:
https://doaj.org/article/b8fc4cc13a6f453f99279058b44d1722
Autor:
George V Aslanidi, Angela E Rivers, Luis Ortiz, Liujiang Song, Chen Ling, Lakshmanan Govindasamy, Kim Van Vliet, Mengqun Tan, Mavis Agbandje-McKenna, Arun Srivastava
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59142 (2013)
The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of AAV2 vectors, and phosphorylation of certain surface-exposed amino acid residues on the capsid provides the primary signal for ubiquitination. Removal of sever
Externí odkaz:
https://doaj.org/article/ad3cc4e20a7a4d0b901038d575181fd8
Autor:
Christine N. Kay, Renee C. Ryals, George V. Aslanidi, Seok Hong Min, Qing Ruan, Jingfen Sun, Frank M. Dyka, Daniel Kasuga, Andrea E. Ayala, Kim Van Vliet, Mavis Agbandje-McKenna, William W. Hauswirth, Sanford L. Boye, Shannon E. Boye
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/1e7d397ee6504d4991261a14ef4ad389
Autor:
Li Zhong, Shaoyong Li, Ran He, Qin Su, Dominic J. Gessler, Terence R. Flotte, Jia Li, Jason E. Goetzmann, Mavis Agbandje-McKenna, Dan Wang, Kim Van Vliet, Karen Tran, Lingzhi Ren, Jun Xie, Guangping Gao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 234-246 (2018)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Adeno-associated virus (AAV) has provided the gene therapy field with the most powerful in vivo gene delivery vector to realize safe, efficacious, and sustainable therapeutic gene expression. Because many clinically relevant properties of AAV-based v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58adfc3253763f7f3731609eafcbc05
http://www.sciencedirect.com/science/article/pii/S2329050118300330
http://www.sciencedirect.com/science/article/pii/S2329050118300330
Autor:
Miranda L. Scalabrino, Jim Peterson, Shreyasi Choudhury, Shannon E. Boye, Antonette Bennett, Qing Ruan, Mavis Agbandje-McKenna, Sanford L. Boye, Kim Van Vliet, K. Tyler McCullough
Publikováno v:
Journal of Virology. 90:4215-4231
Adeno-associated viruses (AAVs) currently are being developed to efficiently transduce the retina following noninvasive, intravitreal (Ivt) injection. However, a major barrier encountered by intravitreally delivered AAVs is the inner limiting membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2a31f2dd1a36a2ceae341023faef27
https://doi.org/10.1128/jvi.00200-16
https://doi.org/10.1128/jvi.00200-16