Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Kim Theilgaard‐Mönch"'
Autor:
Sophia Engelhard, Montserrat Estruch, Shuyu Qin, Christoph A. Engelhard, Francisco G. Rodriguez-Gonzalez, Martine Drilsvik, Javier Martin-Gonzalez, Jeng-Wei Lu, David Bryder, Claus Nerlov, Joachim Weischenfeldt, Kristian Reckzeh, Kim Theilgaard-Mönch
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114475- (2024)
Summary: Endomucin (EMCN) currently represents the only hematopoietic stem cell (HSC) marker expressed by both murine and human HSCs. Here, we report that EMCN+ long-term repopulating HSCs (LT-HSCs; CD150+CD48−LSK) have a higher long-term multi-lin
Externí odkaz:
https://doaj.org/article/3dfc405563e042acaabd1378d8d20651
Autor:
Kim Theilgaard-Mönch, Sachin Pundhir, Kristian Reckzeh, Jinyu Su, Marta Tapia, Benjamin Furtwängler, Johan Jendholm, Janus Schou Jakobsen, Marie Sigurd Hasemann, Kasper Jermiin Knudsen, Jack Bernard Cowland, Anna Fossum, Erwin Schoof, Mikkel Bruhn Schuster, Bo T. Porse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors show that differentiation of haematopoietic stem cells into mature blood cells is primed by cell type-specific transcription factors at the enhancer level during early differentiation, before they confere promoter-driven growth arres
Externí odkaz:
https://doaj.org/article/c8be37de68644952b82321d25c3ff0a5
Autor:
Thierry Jaffredo, Alessandra Balduini, Anna Bigas, Rosa Bernardi, Dominique Bonnet, Bruno Canque, Pierre Charbord, Anna Cumano, Ruud Delwel, Charles Durand, Willem Fibbe, Lesley Forrester, Lucia de Franceschi, Cedric Ghevaert, Bjørn Gjertsen, Berthold Gottgens, Thomas Graf, Olaf Heidenreich, Olivier Hermine, Douglas Higgs, Marina Kleanthous, Hannes Klump, Valerie Kouskoff, Daniela Krause, George Lacaud, Cristina Lo Celso, Joost H.A. Martens, Simón Méndez-Ferrer, Pablo Menendez, Robert Oostendorp, Sjaak Philipsen, Bo Porse, Marc Raaijmakers, Catherine Robin, Henk Stunnenberg, Kim Theilgaard-Mönch, Ivo Touw, William Vainchenker, Joan-Lluis Vives Corrons, Laurent Yvernogeau, Jan Jacob Schuringa
Publikováno v:
HemaSphere, Vol 5, Iss 12, p e669 (2021)
Externí odkaz:
https://doaj.org/article/b92def9715344d93ad65db2c745664f9
Autor:
Kristian Reckzeh, Hüsün Kizilkaya, Alexandra Søgaard Helbo, Montserrat Estruch Alrich, André Gundersen Deslauriers, Amit Grover, Nicolas Rapin, Fazila Asmar, Kirsten Grønbæk, Bo Porse, Niels Borregaard, Dietmar Vestweber, Claus Nerlov, Kim Theilgaard-Mönch
Publikováno v:
Blood Advances, Vol 2, Iss 13, Pp 1628-1632 (2018)
Externí odkaz:
https://doaj.org/article/2f66945dee264ca7845692de80ef5b07
Autor:
Nan Hu, Helena Mora-Jensen, Kim Theilgaard-Mönch, Berber Doornbos-van der Meer, Minke G Huitema, Coen A Stegeman, Peter Heeringa, Cees G M Kallenberg, Johanna Westra
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99671 (2014)
ObjectiveDifferential gene expression in CD177+ and CD177- neutrophils was investigated, in order to detect possible differences in neutrophil function which could be related to the pathogenesis of ANCA-associated Vasculitides (AAV).MethodsNeutrophil
Externí odkaz:
https://doaj.org/article/b6660195b8d34d87be429bd05cd7e26c
Autor:
Maria T Larsen, Christoffer Hother, Mattias Häger, Corinna C Pedersen, Kim Theilgaard-Mönch, Niels Borregaard, Jack B Cowland
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58454 (2013)
The purpose of this study was to describe the microRNA (miRNA) expression profiles of neutrophils and their precursors from the initiation of granulopoiesis in the bone marrow to extravasation and accumulation in skin windows. We analyzed three diffe
Externí odkaz:
https://doaj.org/article/36eac848033041eaa9f8ddf61fe23bf5
Autor:
Marie S Hasemann, Mikkel B Schuster, Anne-Katrine Frank, Kim Theilgaard-Mönch, Thomas Å Pedersen, Claus Nerlov, Bo T Porse
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38841 (2012)
BackgroundTranscription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical a
Externí odkaz:
https://doaj.org/article/435adf3ec52b4d42a64f1396f579cd8c
Autor:
Kim Theilgaard-Mönch, Thomas Helleday, Ulrika Warpman Berglund, Sophia Engelhard, Camilla Vittori, Kumar Sanjiv, Kristian Reckzeh, Montserrat Estruch, Anders Centio
Currently, the majority of patients with acute myeloid leukemia (AML) still die of their disease due to primary resistance or relapse toward conventional reactive oxygen species (ROS)- and DNA damage–inducing chemotherapy regimens. Herein, we explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d214d6aedb84973092fd78ecb7c18fe
https://doi.org/10.1158/1535-7163.c.6543309
https://doi.org/10.1158/1535-7163.c.6543309
Autor:
Kim Theilgaard-Mönch, Thomas Helleday, Ulrika Warpman Berglund, Sophia Engelhard, Camilla Vittori, Kumar Sanjiv, Kristian Reckzeh, Montserrat Estruch, Anders Centio
Supplementary Figure from Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d2b851cc283c27330d8dc9028e56f9
https://doi.org/10.1158/1535-7163.22522218.v1
https://doi.org/10.1158/1535-7163.22522218.v1
Autor:
Ulrika Warpman Berglund, Thomas Helleday, Julian Walfridsson, Päivi Östling, Mathew J. Garnett, Kim Theilgaard-Mönch, Sören Lehmann, Teresa Sandvall, Olov Wallner, Martin Henriksson, Tobias Koolmeister, Martin Scobie, Torkild Visnes, Nona Struyf, Thea Kristin Våtsveen, Montserrat Estruch, Anders Centio, Stefanie Friedrich, Azita Rasti, Camilla Göktürk, Elisee Wiita, Helge Gad, Akhilesh Nagesh Danda, Brinton Seashore-Ludlow, Yaser Heshmati, Andreas Höglund, Ingrid Almlöf, Viktoriia Tsuber, Tom Erkers, Therese M. Pham, José Manuel Calderón-Montaño, Kumar Sanjiv
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested to drive leukemogenesis and is thus a potential novel target for treating AML. MTH1 prevents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc3a2e4a790d48cfedb4902184be996
https://doi.org/10.1158/0008-5472.c.6533174.v1
https://doi.org/10.1158/0008-5472.c.6533174.v1