Itaconimides as Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

Autor: July Fong, Kim T. Mortensen, Amalie Nørskov, Katrine Qvortrup, Liang Yang, Choon Hong Tan, Thomas E. Nielsen, Michael Givskov

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2019)

Pseudomonas aeruginosa is known as an opportunistic pathogen that often causes persistent infections associated with high level of antibiotic-resistance and biofilms formation. Chemical interference with bacterial cell-to-cell communication, termed q

Externí odkaz: https://doaj.org/article/bc1d1d7b987144d1a00125b26f3fe487

Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy

Autor: Abigail R. Hanby, Stephen J. Walsh, Andrew J. Counsell, Nicola Ashman, Kim T. Mortensen, Jason S. Carroll, David R. Spring

Publikováno v: Chemical communications (Cambridge, England). 58(67)

Herein we report the development of a methodology for the dual-functionalisation of IgG antibodies. This is accomplished through the combination of disulfide rebridging divinylpyrimidine technology, with bicyclononyne and methylcyclopropene handles t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9133af13312b865912a4a34013d053c
https://pubmed.ncbi.nlm.nih.gov/35912884

Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

Autor: Abigail R. Hanby, Sarah L. Kidd, Thomas J. Osberger, Kim T. Mortensen, Nikolaj S. Troelsen, David R. Spring

Publikováno v: Hanby, A R, Troelsen, N S, Osberger, T J, Kidd, S L, Mortensen, K T & Spring, D R 2020, ' Fsp 3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery ', Chemical Communications, vol. 56, 2280 . https://doi.org/10.1039/c9cc09796a

Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a1a40755682a5ada095e4f5f3638d9
https://orbit.dtu.dk/en/publications/cb26f2f3-abf9-4018-a2c5-b8d91361bb70

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery

Autor: Kim T. Mortensen, Thomas A. King, Hannah L. Stewart, David R. Spring, Andrew J. P. North, Hannah F. Sore

Publikováno v: European Journal of Organic Chemistry

In recent years the pharmaceutical industry has benefited from the advances made in fragment-based drug discovery (FBDD) with more than 30 fragment-derived drugs currently marketed or progressing through clinical trials. The success of fragment-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02824b02e58fd1f168f32c5f7bf7b9e4
https://pubmed.ncbi.nlm.nih.gov/31598091

Oxidative Modification of Tryptophan-Containing Peptides

Autor: Katrine Qvortrup, Vitaly V. Komnatnyy, Kim T. Mortensen, Jonas O. Petersen, Thomas E. Nielsen, Katrine E. Christensen, Mathias T. Nielsen

Publikováno v: Petersen, J, Christensen, P K, Nielsen, M T, Mortensen, K T, Komnatnyy, V V, Nielsen, T E & Qvortrup, K 2018, ' Oxidative Modification of Tryptophan-Containing Peptides ', A C S Combinatorial Science, vol. 20, no. 6 . https://doi.org/10.1021/acscombsci.8b00014

We herein present a broadly useful method for the chemoselective modification of a wide range of tryptophan-containing peptides. Exposing a tryptophan-containing peptide to 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) resulted in a selective cyclo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925dfdd9ec4643ada17a379324dea00f
https://orbit.dtu.dk/en/publications/c40f7ccf-07ef-43a9-83b8-938a313acb2f