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Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia

Autor: Salvador Nares, Anthony M. Iacopino, Christopher W. Cutler, James Fojt, Russell E. Dill, Kim Stoever, Andrea Gonzales, Deborah Doxey

Publikováno v: Scopus-Elsevier

Phenytoin (pht) is an anticonvulsant drug commonly used for the prevention of seizures. A common side effect of PHT therapy is gingival hyperplasia, occasionally so severe that it requires surgical intervention. Cyclosporine A (CSA) is a drug widely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e4c0dc2c0e97c0456670f60abe74a3
https://pubmed.ncbi.nlm.nih.gov/9029455

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Akademický článek

Cyclosporin A suppresses Porphyromonas gingivalis lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1.

Autor: Jiang, Lei¹ (AUTHOR), Liu, Min Ni² (AUTHOR), Wang, Guo Dong¹ (AUTHOR), Wu, Qun² (AUTHOR), Zhao, Yun Fu¹ (AUTHOR)

Publikováno v: Growth Factors. Feb2020, Vol. 38 Issue 2, p65-74. 10p.

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Akademický článek

Phenytoin and Cyclosporine A Specifically Regulate Macrophage Phenotype and Expression of Platelet‐Derived Growth Factor and Interleukin‐1 In Vitro and In Vivo: Possible Molecular Mechanism of Drug‐Induced Gingival Hyperplasia.

Autor: Iacopino, Anthony M., Doxey, Deborah, Cutler, Christopher W., Nares, Salvador, Stoever, Kim, Fojt, James, Gonzales, Andrea, Dill, Russell E.

Publikováno v: Journal of Periodontology; Jan1997, Vol. 68 Issue 1, p73-83, 11p

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