Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kim Stever"'
Autor:
Andrew G. Cole, Steven G. Kultgen, Nagraj Mani, Andrzej Ardzinski, Kristi Yi Fan, Emily P. Thi, Bruce D. Dorsey, Kim Stever, Tim Chiu, Sunny Tang, Owen Daly, Janet R. Phelps, Troy Harasym, Andrea Olland, Robert K. Suto, Michael J. Sofia
Publikováno v:
RSC Med Chem
Disruption of the HBV viral life cycle with small molecules that prevent the encapsidation of pregenomic RNA and viral polymerase through binding to HBV core protein is a clinically validated approach to inhibiting HBV viral replication. Herein we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3d746e0df2833c3377ff3c4df6151d
https://europepmc.org/articles/PMC8942244/
https://europepmc.org/articles/PMC8942244/
Autor:
Kristi Fan, Andrea Cuconati, Robbin Burns, Xiaowei Teng, Amy C.H. Lee, Nagraj Mani, Ellen Evangelista, Bruce D. Dorsey, Sunny Tang, Salam Kadhim, Roseann Kowalski, Angela Miller, Troy Harasym, Janet R. Phelps, Kim Stever, Andrzej Ardzinski, Alice H. Li, Chris Pasetka, Rene Rijnbrand, Andrew G. Cole, Holly M. Micolochick Steuer, Stephen P. Reid, Steven G. Kultgen, Michael J. Sofia, Xiaohe Wang, Tim T. Chiu, Sara A. Majeski, Fang Guo
Publikováno v:
Antiviral research. 197
AB-506, a small-molecule inhibitor targeting the HBV core protein, inhibits viral replication in vitro (HepAD38 cells: EC50 of 0.077 μM, CC50 > 25 μM) and in vivo (HBV mouse model: ∼3.0 log10 reductions in serum HBV DNA compared to the vehicle co
Autor:
Emily P. Thi, Andrew G. Cole, Gavin Heffernan, Christina Iott, Seyma Ozturk, Sharie C Ganchua, Dan Nguyen, Ingrid Graves, Vijay Ahuja, Kim Stever, Kristi Fan, Jorge G. Quintero, Steven G. Kultgen, Maria Shubina, Boya Liu, Sunny Tang, Troy O. Harasym, Angela M Lam, Michael J. Sofia
Publikováno v:
Journal of Hepatology. 77:S848
Autor:
Emily P. Thi, Andrew G. Cole, Gavin Heffernan, Christina L. Iott, Seyma Ozturk, Sharie C. Ganchua, Dan Nguyen, Ingrid Graves, Jorge G. Quintero, Kim Stever, Kristi Fan, Vijay Ahuja, Steven G. Kultgen, Maria Shubina, Boya Liu, Sunny Tang, Troy Harasym, Angela M. Lam, Michael J. Sofia
Publikováno v:
Journal of Clinical Oncology. 40:e14558-e14558
e14558 Background: The PD-1/PD-L1 checkpoint axis is a validated target in oncology, and immunotherapy with antibody approaches have proven efficacy across various tumor types. Oral small-molecule inhibitors of PD-L1 may offer advantages over antibod
Autor:
Richeng Mao, Bruce D. Dorsey, Andrew G. Cole, Quanxin Long, Alice H. L. Li, Sunny Tang, Rene Rijnbrand, Troy Harasym, Ellen Evangelista, Xiaohe Wang, Nicholas M. Snead, Kevin McClintock, Sara A. Majeski, Haitao Guo, Nagraj Mani, Kyle D. Cobarrubias, Stephen P. Reid, Fang Guo, Holly M. Micolochick Steuer, Janet R. Phelps, Steven G. Kultgen, Andrea Cuconati, Ju-Tao Guo, Qiong Zhao, Amy C.H. Lee, Salam Kadhim, Kim Stever, Kristi Fan, Andrzej Ardzinski, Michael J. Sofia
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62
AB-423 is a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors in phase 1 clinical trials. In cell culture models, AB-423 showed potent inhibition of HBV replication (50% effective concentration [EC 50 ] = 0.08
Autor:
Gordon, Devin
Publikováno v:
Newsweek. 12/20/1999, Vol. 134 Issue 25, p8. 1/6p. 1 Color Photograph.
Autor:
Cole AG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA. Electronic address: acole@arbutusbio.com., Kultgen SG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Mani N; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Quintero JG; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Yi Fan K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Ardzinski A; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Stever K; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Dorsey BD; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Phelps JR; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Lee ACH; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Thi EP; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Chiu T; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Tang S; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Horanyi PS; UCB Pharma, 87 Cambridge Park Drive, Cambridge, MA 02140, USA., Mayclin SJ; UCB Pharma, 87 Cambridge Park Drive, Cambridge, MA 02140, USA., Harasym TO; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA., Sofia MJ; Arbutus Biopharma, Inc., 701 Veterans Circle, Warminster, PA 18974, USA.
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Oct 01; Vol. 94, pp. 129456. Date of Electronic Publication: 2023 Aug 25.