Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kim Schuske"'
Autor:
Nikhil Sasidharan, Andrea L. Pappas, Hsiao Fen Han, Mingyu Gu, Mandy Hannemann, Kim Schuske, Susan Dalton, Shigeki Watanabe, Morgan Q. Goulding, Jan Hegermann, Patrick W. Hullett, Erik M. Jorgensen, Qiang Liu, Michael Ailion, Stefan Eimer
Publikováno v:
Neuron. 82(1):167-180
SummaryPeptide neuromodulators are released from a unique organelle: the dense-core vesicle. Dense-core vesicles are generated at the trans-Golgi and then sort cargo during maturation before being secreted. To identify proteins that act in this pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6a26aafb57880b04c8831900d43839
Autor:
Erik M. Jorgensen, Filip Crona, Michel R. Leroux, Brian P. Piasecki, Jan Burghoorn, Kim Schuske, Maria Trieb, Mathieu W. Bakhoum, Prasad Phirke, Swetha Mohan, Peter Swoboda, Evgeni Efimenko
Publikováno v:
Developmental Biology. 357:235-247
Cilia are ubiquitous cell surface projections that mediate various sensory- and motility-based processes and are implicated in a growing number of multi-organ genetic disorders termed ciliopathies. To identify new components required for cilium bioge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873ebe1c0002d958bbbbed61f92d1888
https://doi.org/10.1016/j.ydbio.2011.06.028
https://doi.org/10.1016/j.ydbio.2011.06.028
Publikováno v:
The Journal of Cell Biology
Docking to the plasma membrane prepares vesicles for rapid release. Here, we describe a mechanism for dense core vesicle docking in neurons. In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are excluded fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60ba27938183e6e8e54763b0237d4c9
https://doi.org/10.1083/jcb.200708018
https://doi.org/10.1083/jcb.200708018
Autor:
Erik M. Jorgensen, Kevin S. Hamming, Sean D. Young, Terrance P. Snutch, Colin Thacker, Shigeki Watanabe, Kim Schuske, Maelle Jospin, Deepa Joshi
Publikováno v:
Current Biology. 17:1595-1600
SummarySynaptojanin is a lipid phosphatase required to degrade phosphatidylinositol 4,5 bisphosphate (PIP2) at cell membranes during synaptic vesicle recycling [1, 2]. Synaptojanin mutants in C. elegans are severely uncoordinated and are depleted of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664f98b2e2073f96021ed71b857322a8
https://doi.org/10.1016/j.cub.2007.08.036
https://doi.org/10.1016/j.cub.2007.08.036
Autor:
M. Wayne Davis, Jean-Louis Bessereau, Ashley Wright, Erik M. Jorgensen, Daniel C. Williams, Kim Schuske
Publikováno v:
Nature. 413:70-74
Transposons have been enormously useful for genetic analysis in both Drosophila and bacteria. Mutagenic insertions constitute molecular tags that are used to rapidly clone the mutated gene. Such techniques would be especially advantageous in the nema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f66a3900b7bee2f76ef0175b006706
https://doi.org/10.1038/35092567
https://doi.org/10.1038/35092567
Publikováno v:
Traffic. 2:597-605
After synaptic vesicle exocytosis, synaptic vesicle proteins must be retrieved from the plasma membrane, sorted away from other membrane proteins, and reconstituted into a functional synaptic vesicle. The nematode Caenorhabditis elegans is an organis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d147557c3783ac19d4900c92cd40e7c
https://doi.org/10.1034/j.1600-0854.2001.002009597.x
https://doi.org/10.1034/j.1600-0854.2001.002009597.x
Autor:
Erik M. Jorgensen, Kim Schuske
Publikováno v:
Science. 304:1750-1752
Brain activity depends on the release of the neurotransmitter glutamate by exocytosis of synaptic vesicles. In their Perspective, Schuske and Jorgensen comment on two studies ( Fremeau et al ., Wocjik et al .) that find that mice with the main vesicu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db7f70c19945ef790d84b93ae16d509a
https://doi.org/10.1126/science.1100475
https://doi.org/10.1126/science.1100475
Autor:
Shigeki Watanabe, Kim Schuske, Paul D. Baum, Gian Garriga, Qiang Liu, Erik M. Jorgensen, Mingyu Gu
Publikováno v:
The Journal of Cell Biology
Synaptic vesicles must be recycled to sustain neurotransmission, in large part via clathrin-mediated endocytosis. Clathrin is recruited to endocytic sites on the plasma membrane by the AP2 adaptor complex. The medium subunit (μ2) of AP2 binds to car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13686d0b4e734063bda8f3f5675b726
https://pubmed.ncbi.nlm.nih.gov/19047463
https://pubmed.ncbi.nlm.nih.gov/19047463
Autor:
Kouichi Iwasaki, Matt Petrie, Kyoungsook Ann, Michael Ailion, Erik M. Jorgensen, Kim Schuske, Sean D. Speese, Thomas Martin
Previous studies indicated that CAPS (calcium-dependent activator protein for secretion) functions as an essential component for the Ca(2+)-dependent exocytosis of dense-core vesicles in neuroendocrine cells. However, recent mouse knock-out studies s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942ca741cb0eaa702fc9f672c3f25513
https://europepmc.org/articles/PMC6672138/
https://europepmc.org/articles/PMC6672138/
Publikováno v:
Nature neuroscience. 10(7)
Mutations in unc-46 in Caenorhabditis elegans cause defects in all behaviors that are mediated by GABA. Here we show that UNC-46 is a sorting factor that localizes the vesicular GABA transporter to synaptic vesicles. The UNC-46 protein is related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d93e082f34c6d8bda71ad66da995e66
https://pubmed.ncbi.nlm.nih.gov/17558401
https://pubmed.ncbi.nlm.nih.gov/17558401