Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Kim S. Midwood"'
Autor:
James Ozanne, Mel Lewis, Anja Schwenzer, Dominic Kurian, Jeff Brady, David Pritchard, Gerry McLachlan, Colin Farquharson, Kim S. Midwood
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Serum biomarkers are the gold standard in non-invasive disease diagnosis and have tremendous potential as prognostic and theranostic tools for patient stratification. Circulating levels of extracellular matrix molecules are gaining traction as an eas
Externí odkaz:
https://doaj.org/article/d9c7a7df630743ee8ab0d79d1b4c24bd
Autor:
Alissa Domaingo, Philipp Jokesch, Alexandra Schweiger, Martha Gschwandtner, Tanja Gerlza, Manuel Koch, Kim S. Midwood, Andreas J. Kungl
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14694 (2023)
Tenascin-C (TNC) is a complex glycoprotein of the extracellular matrix (ECM) involved in a plethora of (patho-)physiological processes, such as oncogenesis and inflammation. Since chemokines play an essential role in both disease processes, we have i
Externí odkaz:
https://doaj.org/article/9011af0a98024d60a61f60a3c4779d6b
Autor:
Martha Gschwandtner, Anís N. Gammage, Claire Deligne, Linda F. M. Mies, Alissa Domaingo, Devardarssen Murdamoothoo, Thomas Loustau, Anja Schwenzer, Rupert Derler, Raphael Carapito, Manuel Koch, Matthias Mörgelin, Gertraud Orend, Andreas J. Kungl, Kim S. Midwood
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8365 (2023)
Bidirectional dialogue between cellular and non-cellular components of the tumor microenvironment (TME) drives cancer survival. In the extracellular space, combinations of matrix molecules and soluble mediators provide external cues that dictate the
Externí odkaz:
https://doaj.org/article/33af24ec82844ef08e3637a9ae0c01b1
Autor:
James Ozanne, Brandon Shek, Louise A. Stephen, Amanda Novak, Elspeth Milne, Gerry Mclachlan, Kim S. Midwood, Colin Farquharson
Publikováno v:
Matrix Biology Plus, Vol 14, Iss , Pp 100112- (2022)
Inflammatory Bowel Disease (IBD) is a grouping of chronic inflammatory disorders of the gut. Tenascin-C is a pro-inflammatory, extracellular matrix protein found upregulated in IBD patients and whilst a pathological driver of chronic inflammation, it
Externí odkaz:
https://doaj.org/article/efe28cc97485484a948d1f263e3f09b7
Autor:
Jesse A. Coker, Vittorio L. Katis, Michael Fairhead, Anja Schwenzer, Stine B. Clemmensen, Bent U. Frandsen, Willem A. de Jongh, Opher Gileadi, Nicola A. Burgess-Brown, Brian D. Marsden, Kim S. Midwood, Wyatt W. Yue
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Recombinant protein expression in eukaryotic insect cells is a powerful approach for producing challenging targets. However, due to incompatibility with standard baculoviral platforms and existing low-throughput methodology, the use of the Drosophila
Externí odkaz:
https://doaj.org/article/b1a66327cf994b558e7f1cba4b4aa7bc
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/4547c8a06717478190ccd3bd0ff30832
Autor:
Jing Song, Anja Schwenzer, Alicia Wong, Sara Turcinov, Cliff Rims, Lorena Rodriguez Martinez, David Arribas-Layton, Christina Gerstner, Virginia S. Muir, Kim S. Midwood, Vivianne Malmström, Eddie A. James, Jane H. Buckner
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Tenascin-C (TNC), an extracellular matrix protein that has proinflammatory properties, is a recently described antibody target in rheumatoid arthritis (RA). In this study, we utilized a systematic discovery process and identified 5 potentially novel
Externí odkaz:
https://doaj.org/article/817bed96baa04ee0b9d77c2c5b9df132
Autor:
Claire Deligne, Kim S. Midwood
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Solid cancers such as breast tumors comprise a collection of tumor, stromal and immune cells, embedded within a network of tumor-specific extracellular matrix. This matrix is associated with tumor aggression, treatment failure, chemo- and radio-resis
Externí odkaz:
https://doaj.org/article/f9018b6761e64cf2b418be5b4d8b825c
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types both during physiological immune defense and in pathological circumst
Externí odkaz:
https://doaj.org/article/4659c39a490848f6ba9bd66efafcc953
Autor:
Lorena Zuliani-Alvarez, Anna M. Marzeda, Claire Deligne, Anja Schwenzer, Fiona E. McCann, Brian D. Marsden, Anna M. Piccinini, Kim S. Midwood
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code
Externí odkaz:
https://doaj.org/article/280b5571ad664b09ab67b12a008edf59