Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Kim Ravnskjaer"'
Autor:
Yuka Inaba, Emi Hashiuchi, Hitoshi Watanabe, Kumi Kimura, Yu Oshima, Kohsuke Tsuchiya, Shin Murai, Chiaki Takahashi, Michihiro Matsumoto, Shigetaka Kitajima, Yasuhiko Yamamoto, Masao Honda, Shun-ichiro Asahara, Kim Ravnskjaer, Shin-ichi Horike, Shuichi Kaneko, Masato Kasuga, Hiroyasu Nakano, Kenichi Harada, Hiroshi Inoue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aggravation of liver steatosis shifts the hepatocellular death mode from apoptosis to necroptosis in acute and chronic liver damage. Here the authors report that the transcription factor ATF3 regulates this shift through the induction of RIPK3, a reg
Externí odkaz:
https://doaj.org/article/6e96d9a1b7674a218452a1194f8c9e95
Autor:
Mei Li, Frederik T. Larsen, Marius C. van den Heuvel, Konstanze Gier, Alan R. Gorter, Dorenda Oosterhuis, Johan Bijzet, Vincent E. de Meijer, Kim Ravnskjaer, Anika Nagelkerke, Peter Olinga
Publikováno v:
Nutrients, Vol 16, Iss 5, p 626 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing healthcare problem with limited therapeutic options. Progress in this field depends on the availability of reliable preclinical models. Human precision-cut liver slices (PC
Externí odkaz:
https://doaj.org/article/4c1560dd97c24c469d10e64a52a970a4
Autor:
Marie Bobowski-Gerard, Clémence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Céline Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loïc Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloïse Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianférani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Réjane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, François Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.
Externí odkaz:
https://doaj.org/article/c0d2d56ec91641b79809fad780054395
Autor:
Frederik T. Larsen, Daniel Hansen, Mike K. Terkelsen, Sofie M. Bendixen, Fabio Avolio, Charlotte W. Wernberg, Mette M. Lauridsen, Lea L. Grønkjaer, Birgitte G. Jacobsen, Ellen G. Klinggaard, Susanne Mandrup, Tina Di Caterino, Majken S. Siersbæk, Vineesh Indira Chandran, Jonas H. Graversen, Aleksander Krag, Lars Grøntved, Kim Ravnskjaer
Publikováno v:
JHEP Reports, Vol 5, Iss 2, Pp 100615- (2023)
Background & Aims: Histological assessment of liver biopsies is the gold standard for diagnosis of non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD), despite its well-established limitations. Ther
Externí odkaz:
https://doaj.org/article/018dbabd75474726b81d204c600b8e22
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 5, p 930 (2021)
Liver disease due to metabolic dysfunction constitute a worldwide growing health issue. Severe obesity is a particularly strong risk factor for non-alcoholic fatty liver disease, which affects up to 93% of these patients. Current diagnostic markers f
Externí odkaz:
https://doaj.org/article/259f6a2d123d40009ecb207b5611043b
Autor:
Adhyatmika Adhyatmika, Leonie Beljaars, Kurnia S. S. Putri, Habibie Habibie, Carian E. Boorsma, Catharina Reker-Smit, Theerut Luangmonkong, Burak Guney, Axel Haak, Keri A. Mangnus, Eduard Post, Klaas Poelstra, Kim Ravnskjaer, Peter Olinga, Barbro N. Melgert
Publikováno v:
Pharmaceutics, Vol 12, Iss 5, p 471 (2020)
Osteoprotegerin (OPG) serum levels are associated with liver fibrogenesis and have been proposed as a biomarker for diagnosis. However, the source and role of OPG in liver fibrosis are unknown, as is the question of whether OPG expression responds to
Externí odkaz:
https://doaj.org/article/b319b910af32449c8e3333c092aedcec
Autor:
Kim Ravnskjaer, Francesca Frigerio, Michael Boergesen, Tina Nielsen, Pierre Maechler, Susanne Mandrup
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 6, Pp 1370-1379 (2010)
The peroxisome proliferator-activated receptor δ (PPARδ) is implicated in regulation of mitochondrial processes in a number of tissues, and PPARδ activation is associated with decreased susceptibility to ectopic lipid deposition and metabolic dise
Externí odkaz:
https://doaj.org/article/694882c2a8e7492b9dff5dcf1b85aa23
Autor:
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen
Publikováno v:
Indira Chandran, V, Wernberg, C W, Lauridsen, M M, Skytthe, M K, Bendixen, S M, Larsen, F T, Hansen, C D, Grønkjær, L L, Siersbæk, M S, Caterino, T D, Detlefsen, S, Møller, H J, Grøntved, L, Ravnskjaer, K, Moestrup, S K, Thiele, M S, Krag, A & Graversen, J H 2023, ' Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness ', Hepatology, vol. 77, no. 2, pp. 558-572 . https://doi.org/10.1002/hep.32620
Background and Aims: Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomark
Autor:
Kim Ravnskjaer, Sönke Detlefsen, Thomas Andersen, Anders Schlosser, Emma A.H. Scott, Andreas F. Moeller, Aleksander Krag, Henrik Dimke, Susanne Mandrup, Daniel Aaen Hansen, Kedar Nath Natarajan, Ronni Nielsen, Mike Krogh Terkelsen, Sofie M. Bendixen, Grith Lykke Sørensen
Publikováno v:
Hepatology (Baltimore, Md.)
Terkelsen, M K, Bendixen, S M, Hansen, D, Scott, E A H, Moeller, A F, Nielsen, R, Mandrup, S, Schlosser, A, Andersen, T L, Sorensen, G L, Krag, A, Natarajan, K N, Detlefsen, S, Dimke, H & Ravnskjaer, K 2020, ' Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury ', Hepatology, vol. 72, no. 6, pp. 2119-2133 . https://doi.org/10.1002/hep.31215
Terkelsen, M K, Bendixen, S M, Hansen, D, Scott, E A H, Moeller, A F, Nielsen, R, Mandrup, S, Schlosser, A, Andersen, T L, Sorensen, G L, Krag, A, Natarajan, K N, Detlefsen, S, Dimke, H & Ravnskjaer, K 2020, ' Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury ', Hepatology, vol. 72, no. 6, pp. 2119-2133 . https://doi.org/10.1002/hep.31215
Background and Aims: Hepatic sinusoidal cells are known actors in the fibrogenic response to injury. Activated hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and Kupffer cells are responsible for sinusoidal capillarization and per
Autor:
Shigenobu Matsumura, Kim Ravnskjaer, Tsuyoshi Goto, Tomoki Jinno, Jin Tanaka, Mike Krogh Terkelsen, Tsutomu Sasaki, Kazuo Inoue, Fuka Ishikawa
Publikováno v:
Matsumura, S, Ishikawa, F, Sasaki, T, Terkelsen, M K, Ravnskjaer, K, Jinno, T, Tanaka, J, Goto, T & Inoue, K 2021, ' Loss of CREB coactivator CRTC1 in SF1 cells leads to hyperphagia and obesity by high-fat diet but not normal chow diet ', Endocrinology, vol. 162, no. 9, bqab076 . https://doi.org/10.1210/endocr/bqab076
Endocrinology
Endocrinology
Cyclic adenosine monophosphate responsive element–binding protein-1-regulated transcription coactivator-1 (CRTC1) is a cytoplasmic coactivator that translocates to the nucleus in response to cyclic adenosine monophosphate. Whole-body knockdown of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c11792fb131fd2a7e19dd00480ad0c8
https://findresearcher.sdu.dk:8443/ws/files/184073250/bqab076.pdf
https://findresearcher.sdu.dk:8443/ws/files/184073250/bqab076.pdf