Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kim Q Tran"'
Autor:
Martin Oft, Michael Totagrande, Luis Zuniga, David B Rosen, Priyanka Balasubrahmanyam, Zhenya Koliesnik, Ryan Burgess, Kim Q Tran, Michele Bauer, Bharghavi Jayaraman, Cindy Buffone, Jan Emmerich, Deepti Chaturvedi, Deepti Rokkam, Rene De Waal Malefyt, Heiko Greb, Navneet Ratti, Sandro Vivona, Robert Kastelein, Patrick Lupardus
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/3e0b02efc0da4cb49b22cd8ab1e23832
Autor:
Nadine S. Jahchan, Jing Shan Lim, Becky Bola, Karen Morris, Garrett Seitz, Kim Q. Tran, Lei Xu, Francesca Trapani, Christopher J. Morrow, Sandra Cristea, Garry L. Coles, Dian Yang, Dedeepya Vaka, Michael S. Kareta, Julie George, Pawel K. Mazur, Thuyen Nguyen, Wade C. Anderson, Scott J. Dylla, Fiona Blackhall, Martin Peifer, Caroline Dive, Julien Sage
Publikováno v:
Cell Reports, Vol 16, Iss 3, Pp 644-656 (2016)
Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. Th
Externí odkaz:
https://doaj.org/article/42469f1e4e5a450c8d76fbf3b09b570b
Publikováno v:
Composite Structures. 315:116981
Publikováno v:
Aerospace Science and Technology. 137:108270
Abstract 1833: Novel IL-12 Partial Agonist For Cancer Immunotherapy Avoids NK-cell Mediated Toxicity
Autor:
Ievgen Koliesnik, Jan Emmerich, Kim Q. Tran, Michele Bauer, Michael Totagrande, Bhargavi Jayaraman, Cindy Buffone, Priyanka Balasubrahmanyam, Deepti Rokkam, Rene de Waal Malefyt, Luis Zuniga, Heiko Greb, Navneet Ratti, Sandro Vivona, Martin Oft, Patrick J. Lupardus, Robert A. Kastelein
Publikováno v:
Cancer Research. 83:1833-1833
Here we report on a novel human IL-12 partial agonist (hIL-12v) that has diminished binding to IL-12Rb1. IL-12v is designed to more selectively engage antigen activated T-cells, which strongly upregulate IL-12Rb1 upon activation, and to reduce stimul