Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kim May Lee"'
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-6 (2024)
Abstract Background Mediation analysis, often completed as secondary analysis to estimating the main treatment effect, investigates situations where an exposure may affect an outcome both directly and indirectly through intervening mediator variables
Externí odkaz:
https://doaj.org/article/d8085a78f1554df5a963b92bbf3bdcf6
Autor:
Kim May Lee, Richard Emsley
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background A platform trial approach allows adding arms to on-going trials to speed up intervention discovery programs. A control arm remains open for recruitment in a platform trial while intervention arms may be added after the onset of th
Externí odkaz:
https://doaj.org/article/1410e6b13c5648e6a35bfe9c638348af
Autor:
Elizabeth Ball, Babu Karavadra, Bethany Jade Kremer-Yeatman, Connor Mustard, Kim May Lee, Sharandeep Bhogal, Julie Dodds, Andrew W Horne, John Allotey, Carol Rivas
Publikováno v:
Reproduction and Fertility, Vol 2, Iss 1, Pp 69-80 (2021)
Background: Up to 28% of endometriosis patients do not get pain relief from therapeutic laparoscopy but this subgroup is not defined. Objectives: To identify any prognostic patient-specific factors (such as but not limited to patients’ type or loca
Externí odkaz:
https://doaj.org/article/b91c93c32289402d86dca50b3747e7d8
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Platform trials improve the efficiency of the drug development process through flexible features such as adding and dropping arms as evidence emerges. The benefits and practical challenges of implementing novel trial designs have
Externí odkaz:
https://doaj.org/article/e153b54a87034a1fb0faabe561699ba4
Autor:
Kim May Lee, James Wason
Publikováno v:
BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Platform trials allow adding new experimental treatments to an on-going trial. This feature is attractive to practitioners due to improved efficiency. Nevertheless, the operating characteristics of a trial that adds arms have not
Externí odkaz:
https://doaj.org/article/dbfee75080ef486aacb699a04c6762f4
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274272 (2022)
When comparing the performance of multi-armed bandit algorithms, the potential impact of missing data is often overlooked. In practice, it also affects their implementation where the simplest approach to overcome this is to continue to sample accordi
Externí odkaz:
https://doaj.org/article/09a455d145f74a119a7905d3f3b76f7b
Publikováno v:
Statistics in Medicine. 42:1156-1170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5868ab1c110eba8e03d6e4960a9ac48f
https://doi.org/10.1002/sim.9663
https://doi.org/10.1002/sim.9663
Publikováno v:
Anesthesiology. 136:148-161
Background The relationship between late clinical outcomes after injury and early dynamic changes between fibrinolytic states is not fully understood. The authors hypothesized that temporal transitions in fibrinolysis states using rotational thromboe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efb382e0c5d3723f00f734b0f8385a6
https://doi.org/10.1097/aln.0000000000004036
https://doi.org/10.1097/aln.0000000000004036
Publikováno v:
King's College London
Response-Adaptive Randomization (RAR) is part of a wider class of data-dependent sampling algorithms, for which clinical trials are typically used as a motivating application. In that context, patient allocation to treatments is determined by randomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55727895f1e8e0bd8df7641a52891a9c
Peer reviewed: True
Funder: Biometrika Trust
Funder: NIHR Maudsley Biomedical Research Centre
Covariate adjustment via a regression approach is known to increase the precision of statistical inference when fixed trial designs are emplo
Funder: Biometrika Trust
Funder: NIHR Maudsley Biomedical Research Centre
Covariate adjustment via a regression approach is known to increase the precision of statistical inference when fixed trial designs are emplo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ca76a87fe69280cba8f2d4c6b59c54