Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Kim M. Smits"'
Autor:
Ghalib Mobaraki, Shuai Shi, Dan Liu, Kim M. Smits, Kim Severens, Kim Lommen, Dorit Rennspiess, Ernst-Jan M. Speel, Véronique Winnepenninckx, Faisal Klufah, Iryna Samarska, Axel zur Hausen
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8213 (2024)
Worldwide, the incidence of renal cell carcinoma (RCC) is rising, accounting for approximately 2% of all cancer diagnoses and deaths. The etiology of RCC is still obscure. Here, we assessed the presence of HPyVs in paraffin-embedded tissue (FFPE) res
Externí odkaz:
https://doaj.org/article/edcc4fea40b04dd8875375da2fcf47eb
Autor:
Ghalib Mobaraki, Shuai Shi, Kim M. Smits, Kim Severens, Kim Lommen, Dorit Rennspiess, Emil Chteinberg, Véronique Winnepenninckx, Iryna Samarska, Faisal Klufah, Axel zur Hausen
Publikováno v:
Cancers, Vol 16, Iss 9, p 1746 (2024)
Previous studies have indicated a potential role of diet in the pathogenesis of renal cell carcinoma (RCC). Recently, circular bovine meat and milk factor (BMMF) DNAs have been identified in peritumoral tissues of human colon and breast cancers. Here
Externí odkaz:
https://doaj.org/article/f0942bd6c45e4b48891f3e2c9a8b2905
Autor:
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van derMeer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike I. Grabsch, Piet A. van denBrandt
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1137-1156 (2023)
Abstract Background Previous research suggests that Warburg‐subtypes are related to potentially important survival differences in colorectal cancer (CRC) patients. In the present study, we investigated whether mutational subgroups based on somatic
Externí odkaz:
https://doaj.org/article/4f16f53a66a34d5caf70310b0fd58b56
Autor:
Jeroen A. A. van de Pol, Paranita Ferronika, Helga Westers, Manon van Engeland, Martijn M. Terpstra, Kim M. Smits, Kim de Lange, Piet A. van den Brandt, Rolf H. Sijmons, Leo J. Schouten, Klaas Kok
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract In this study, we investigate the influence of the seven genes (VHL, PBRM1, SETD2, BAP1, KDM5C, MTOR and TP53) most frequently mutated in clear cell renal cell cancer (ccRCC) on cancer-specific survival (CSS) in the prospective Netherlands C
Externí odkaz:
https://doaj.org/article/c6048eb133a44760a00156881a3a8d91
Autor:
Tim C. de Ruijter, Frank van der Heide, Kim M. Smits, Maureen J. Aarts, Manon van Engeland, Vivianne C. G. Heijnen
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Abstract Background In patients with hormone receptor-positive breast cancer, differentiating between patients with a low and a high risk of recurrence is an ongoing challenge. In current practice, prognostic clinical parameters are used for risk pre
Externí odkaz:
https://doaj.org/article/9540d4d407c0495dab81dec054c55d77
Autor:
Tim C. de Ruijter, Kim M. Smits, Maureen J. Aarts, Irene E. G. van Hellemond, Leander Van Neste, Bart de Vries, Petronella G. M. Peer, Jürgen Veeck, Manon van Engeland, Vivianne C. G. Tjan-Heijnen
Publikováno v:
Diagnostic and Prognostic Research, Vol 3, Iss 1, Pp 1-8 (2019)
Abstract Background The effect of extended adjuvant aromatase inhibition in hormone-positive breast cancer after sequential tamoxifen, aromatase inhibitor treatment of 5 years was recently investigated by the DATA study. This study found no statistic
Externí odkaz:
https://doaj.org/article/f6e07aacda75400586e399d84923b11c
Autor:
Muriel X. G. Draht, Danny Goudkade, Alexander Koch, Heike I. Grabsch, Matty P. Weijenberg, Manon van Engeland, Veerle Melotte, Kim M. Smits
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Biomarkers that can predict the prognosis of colorectal cancer (CRC) patients and that can stratify high-risk early stage patients from low-risk early stage patients are urgently needed for better management of CRC. During the las
Externí odkaz:
https://doaj.org/article/8bf585c0f0b24788a1194912ebec594b
Publikováno v:
Cancers, Vol 12, Iss 4, p 776 (2020)
Although population-wide screening programs for several cancer types have been implemented in multiple countries, screening procedures are invasive, time-consuming and often perceived as a burden for patients. Molecular biomarkers measurable in non-i
Externí odkaz:
https://doaj.org/article/b0bdd48077ac44928f4f14512bb6d946
Autor:
Marcella M. Baldewijns, Iris J. H. van Vlodrop, Kim M. Smits, Peter B. Vermeulen, Gert G. Van den Eynden, Fiona Schot, Tania Roskams, Hein van Poppel, Manon van Engeland, Adriaan P. de Bruïne
Publikováno v:
Cellular Oncology, Vol 31, Iss 5, Pp 371-382 (2009)
Background: von Hippel–Lindau (VHL) inactivation is common in sporadic clear cell renal cell carcinomas (ccRCC). pVHL is part of the ubiquitin ligase complex that targets the alpha subunits of hypoxia-inducible transcription factor (HIF) for degrad
Externí odkaz:
https://doaj.org/article/e578e2c40e7a44fe984e018d2f677923
Autor:
Josien C. A. Jenniskens, Kelly Offermans, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike I. Grabsch, Piet A. van den Brandt
Publikováno v:
Molecular Carcinogenesis, 61(12), 1099-1115. Wiley-Liss Inc.
KRAS mutations (KRASmut ), PIK3CAmut , BRAFmut , and deficient DNA mismatch repair (dMMR) have been associated with the Warburg effect. We previously reported differential associations between early-life energy balance-related factors (height, energy