MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1

Autor: Ana P. Lopes, Joel A. G. van Roon, Sofie L. M. Blokland, Maojie Wang, Eleni Chouri, Sarita A. Y. Hartgring, Kim M. G. van der Wurff-Jacobs, Aike A. Kruize, Boudewijn M. T. Burgering, Marzia Rossato, Timothy R. D. J. Radstake, Maarten R. Hillen

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Objectives: Considering the critical role of microRNAs (miRNAs) in regulation of cell activation, we investigated their role in circulating type-2 conventional dendritic cells (cDC2s) of patients with primary Sjögren's syndrome (pSS) compared to hea

Externí odkaz: https://doaj.org/article/3a7902173977420cbbcbec6212b5cab0

Potential Use of Extracellular Vesicles Generated by Microbubble-Assisted Ultrasound as Drug Nanocarriers for Cancer Treatment

Autor: Kim M G van der Wurff-Jacobs, Yuana Yuana, Chrit T. W. Moonen, Banuja Balachandran, Raymond M. Schiffelers

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 3024, p 3024 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 8

Extracellular vesicles (EVs)-carrying biomolecules derived from parental cells have achieved substantial scientific interest for their potential use as drug nanocarriers. Ultrasound (US) in combination with microbubbles (MB) have been shown to trigge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576239738562300784e1de9924bffb43
https://www.mdpi.com/1422-0067/21/8/3024

Assessment of Intratumoral Doxorubicin Penetration after Mild Hyperthermia-mediated Release from Thermosensitive Liposomes

Autor: Quincy Q van Houtum, Kim M G van der Wurff-Jacobs, Angelique D. Barten-Van Rijbroek, Ludwig Dubois, Chrit T. W. Moonen, Jean-Michel Escoffre, Marc Derieppe, Baudouin Denis de Senneville, Clemens Bos

Publikováno v: Contrast Media and Molecular Imaging
Contrast Media and Molecular Imaging, Wiley, 2019, ⟨10.1155/2019/2645928⟩
Contrast Media & molecular imaging, 2019. John Wiley and Sons Ltd
Contrast Media & Molecular Imaging
Contrast Media & Molecular Imaging, Vol 2019 (2019)
Contrast Media and Molecular Imaging, 2019, ⟨10.1155/2019/2645928⟩
Contrast Media & Molecular Imaging, 2019:2645928, 1-13. Wiley Hindawi Partnership

In solid tumors, rapid local intravascular release of anticancer agents, e.g., doxorubicin (DOX), from thermosensitive liposomes (TSLs) can be an option to overcome poor extravasation of drug nanocarriers. The driving force of DOX penetration is the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258e35e062a64241a39a5141f9346c49
https://hal.archives-ouvertes.fr/hal-02377672/file/2645928.pdf

Clinical efficacy of leflunomide in primary Sjögren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression

Autor: Johannes W. J. Bijlsma, Jan-Maarten van Woerkom, A. Bikker, Aike A. Kruize, Floris P J G Lafeber, Kim M G van der Wurff-Jacobs, Joel A G van Roon

Publikováno v: Annals of the Rheumatic Diseases. 71:1934-1941

Objectives To investigate whether the immunomodulatory capacities of leflunomide are associated with clinical efficacy in the treatment of primary Sjogren9s syndrome (SS) in a phase II pilot study. Methods Peripheral blood mononuclear cells from 13 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda2b5848163aa3559bccf86cfb8d558
https://doi.org/10.1136/annrheumdis-2011-201026

Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1/PD-L1 interactions

Autor: Johannes W. J. Bijlsma, Kim M G van der Wurff-Jacobs, Floris P J G Lafeber, Frederique M Moret, Joel A G van Roon

Publikováno v: Arthritis Research & Therapy

Introduction: The aim of this study was to investigate PD-1/PD-L1 involvement in the hyporesponsiveness of rheumatoid arthritis (RA) synovial fluid (SF) CD4 T cells upon stimulation by thymic stromal lymphopoietin (TSLP)–primed CD1c myeloid dendrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302ca5c4f442cf700e246c4b2e3d598f
https://pubmed.ncbi.nlm.nih.gov/25433812