Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Kim M O'Sullivan"'
Autor:
Joanna R Ghali, Kim M O'Sullivan, Peter J Eggenhuizen, Stephen R Holdsworth, A Richard Kitching
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123118 (2015)
Fms-like tyrosine kinase 3-ligand (FL) is a growth factor that may expand dendritic cell and regulatory T cell populations. We hypothesised that FL-induced regulatory T cells would protect mice from experimental rapidly progressive glomerulonephritis
Externí odkaz:
https://doaj.org/article/b82402d73a524bd3ba747305ffffd658
Autor:
Sharon L. Ford, Kim M. O’Sullivan, A. Richard Kitching, Stephen R. Holdsworth, Poh Yi Gan, Shaun A. Summers
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1339 (2023)
ANCA-associated vasculitis (AAV) is intricately linked with infections. Toll-like receptors (TLR) provide a potential link between infection and anti-myeloperoxidase (MPO) autoimmunity. TLR9 ligation has been shown to promote anti-MPO autoimmunity an
Externí odkaz:
https://doaj.org/article/891f048a26584d48ac71a9dafef47d7e
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Our understanding of immune recognition and response to infection and non-infectious forms of cell damage and death is rapidly increasing. The major focus is on host immunity and microbiological invasion. However, it is also clear that these same pat
Externí odkaz:
https://doaj.org/article/7b69170fd6e0428e85f2b9ff6f0885f1
Autor:
Xiaoyong Chen, Benedette J. Cuffari, Valentina Dubljevic, Anupama Shirali, Jiangbing Zhou, James A. Campbell, Stephen C. Suits, Kim M. O’Sullivan, James E. Hansen
Publikováno v:
ImmunoHorizons. 6:356-365
Nuclear-penetrating anti-DNA autoantibodies have therapeutic potential as delivery agents and in targeting DNA and the DNA damage response (DDR). Derivatives of such Abs have advanced to human testing in genetic disease and are in preparation for onc
Autor:
Amina Ahmad, Mawj Mandwie, Kim M. O'Sullivan, Christine Smyth, Jarrod York, Helen Doyle, Stephen R. Holdsworth, Matthew C. Pickering, Peter J. Lachmann, Ian E. Alexander, Grant J. Logan
Publikováno v:
Human Gene Therapy. 33:560-571
Adeno-associated virus (AAV) vectors are proving to be clinically transformative tools in the treatment of monogenic genetic disease. Rapid ongoing development of this technology promises to not only increase the number of monogenic disorders amenabl
Autor:
Melanie L.R. Wyld, Nicole L. De La Mata, Andrea Viecelli, Ramyasuda Swaminathan, Kim M O'Sullivan, Emma O'Lone, Matthew Rowlandson, Anna Francis, Kate Wyburn, Angela C. Webster
Publikováno v:
Seminars in Nephrology. 42:153-169
Globally, females are ∼30% more likely to have pre-dialysis chronic kidney disease (CKD) than males for reasons that are not fully understood. CKD is associated with numerous adverse health outcomes which makes understanding and working to eradicat
Autor:
Kim M. O’Sullivan, Virginie Oudin, Anne Cao Le, Jonathan Dick, Raymond Shim, Stephen R. Holdsworth, Daniel Koo Yuk Cheong, A. Richard Kitching, Joshua D. Ooi, Poh-Yi Gan, Maliha A. Alikhan
Publikováno v:
J Am Soc Nephrol
Background Myeloperoxidase ANCA-associated vasculitis is a major cause of ESKD. Efficacy of anti-CD20 mAb treatment was tested in a mouse model of the disease. Methods MPO immunization induced anti-MPO autoimmunity, and a subnephritogenic dose of she
Autor:
Stephen R. Holdsworth, Philip G. Bardin, Nadeene Clarke, Ken L. Wan, Zhong X. Lu, David S. Armstrong, Roleen Sharma, Jennifer Schaefer, Paul T. King, Rosemary Carzino, Sarath Ranganathan, Kim M. O’Sullivan, Aveena Anantharajah, Lovisa Dousha
Publikováno v:
ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 2 (2021)
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 2 (2021)
Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood. One potentiall
Autor:
Anna, Francis, Kim M, O'Sullivan, Pinika, Patel, Andrea K, Viecelli, James A, Hedley, Ramyasuda, Swaminathan, Amy, Crosthwaite, Imad, Haloob, Alice, Kennard, Matthew, Rowlandson, Neil, Boudville, Angela C, Webster, Kate, Wyburn
Publikováno v:
Internal medicine journal. 52(11)
Despite diversity initiatives, inequities persist in medicine with negative implications for the workforce and patients. Little is known about workplace inequity in nephrology.To describe perceptions and experiences of bias by health professionals in
Autor:
Kim M. O’Sullivan, Kei Nagai, Poh-Yi Gan, A. Richard Kitching, Joshua D. Ooi, Virginie Oudin, Amy J. Chan, Jonathan Dick, Stephen R. Holdsworth, Raymond Shim
Publikováno v:
Kidney International. 96:1121-1133
Anti-myeloperoxidase nephritogenic autoimmunity induces severe glomerulonephritis. To assess the therapeutic potential of monoclonal antibodies targeting T helper (Th) subset differentiation determining cytokines, we studied a murine model of anti-my