Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kim M Miles"'
Autor:
Sara K Lindén, Yong H Sheng, Alison L Every, Kim M Miles, Emma C Skoog, Timothy H J Florin, Philip Sutton, Michael A McGuckin
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000617 (2009)
The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H. pylori in a
Externí odkaz:
https://doaj.org/article/8088459c1b2e435baa2308dee51d9eab
Autor:
Andrew K. Sewell, John J. Miles, Stéphane Quideau, Emily S.J. Edwards, Brian M. Baker, Marion Tarbe, Kim M. Miles
A click chemistry‐based approach was implemented to prepare peptidomimetics designed in silico and made from aromatic azides and a propargylated GIGI‐mimicking platform derived from the altered Melan‐A/MART‐1 26(27L)‐35 antigenic peptide EL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98d497bc2a845ff44c98c602c1f6475
Autor:
Marion, Tarbe, John J, Miles, Emily S J, Edwards, Kim M, Miles, Andrew K, Sewell, Brian M, Baker, Stéphane, Quideau
Publikováno v:
ChemMedChem
A click chemistry-based approach was implemented to prepare peptidomimetics designed in silico and made from aromatic azides and a propargylated GIGI-mimicking platform derived from the altered Melan-A/MART-1(26(27L)-35) antigenic peptide ELAGIGILTV.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::341d050e9348aaf5d095b251d8af45d3
https://pubmed.ncbi.nlm.nih.gov/32162475
https://pubmed.ncbi.nlm.nih.gov/32162475
Autor:
Kim M. Miles, Bent K. Jakobsen, Anna Marta Bulek, Yi Li, Moushumi Hossain, Andrew K. Sewell, Malkit Sami, Brian M. Baker, Anna Fuller, Pierre J. Rizkallah, Nathaniel Liddy, Andrea J. A. Schauenburg, Christopher J. Holland, John J. Miles, David K. Cole, Florian Madura
Publikováno v:
The Journal of Biological Chemistry
Background: The molecular principles governing T-cell specificity are poorly understood. Results: High affinity binding of a melanoma-specific T-cell receptor (TCR) is mediated through new MHC contacts and distinct thermodynamics. Conclusion: A novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3a141f6779f4ec0277ae0850ac7331
http://europepmc.org/articles/PMC3696650
http://europepmc.org/articles/PMC3696650
Autor:
Andrea J. A. Schauenburg, David Price, David K. Cole, John J. Miles, Johanne M. Pentier, Andrew Trimby, Julia Ekeruche-Makinde, Hugo A. van den Berg, Ania Skowera, Mai Ping Tan, Jamie Rossjohn, Garry Dolton, Anna Marta Bulek, Tamsin Williams, Andrew K. Sewell, Kim M. Miles, Sian Llewellyn-Lacey, Mick Bailey, Linda Wooldridge, Mathew Clement, Pierre J. Rizkallah, Scott R. Burrows, Mark Peakman
Publikováno v:
Blood. 121:1112-1123
αβ-TCRs expressed at the CD8(+) T-cell surface interact with short peptide fragments (p) bound to MHC class I molecules (pMHCI). The TCR/pMHCI interaction is pivotal in all aspects of CD8(+) T-cell immunity. However, the rules that govern the outco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d0f45966e93cb14ef7416cdd998570
https://doi.org/10.1182/blood-2012-06-437202
https://doi.org/10.1182/blood-2012-06-437202
Publikováno v:
Molecular Immunology
The majority of known major histocompatibility complex class I (MHCI)-associated tumor-derived peptide antigens do not contain an optimal motif for MHCI binding. As a result, anchor residue-modified ‘heteroclitic’ peptides have been widely used i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dddf155b2f86411cc3ad70005e4db45
Autor:
David K, Cole, Kim M, Miles, Florian, Madura, Christopher J, Holland, Andrea J A, Schauenburg, Andrew J, Godkin, Anna M, Bulek, Anna, Fuller, Hephzibah J E, Akpovwa, Phillip G, Pymm, Nathaniel, Liddy, Malkit, Sami, Yi, Li, Pierre J, Rizkallah, Bent K, Jakobsen, Andrew K, Sewell
Publikováno v:
The Journal of Biological Chemistry
Background: TCR recognition of bipartite ligands composed of self (MHC) and non-self (peptide) maintains T-cell specificity. Results: Mutation of residues in the cognate peptide override TCR mutations that enhance MHC binding. Conclusion: TCR-pMHC bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df747e4c2925d78f3f42d0ae7417772b
https://pubmed.ncbi.nlm.nih.gov/24196962
https://pubmed.ncbi.nlm.nih.gov/24196962
Autor:
Priscilla Do, Andrew K. Sewell, John J. Miles, Brian M. Baker, Emily E. Edwards, Céline Douat-Casassus, Stéphane Quideau, Marion Tarbe, Itxaso Azcune, Eva Balentová, Jesus M. Aizpurua, Kim M. Miles
Publikováno v:
Organicbiomolecular chemistry. 8(23)
β-Lactam peptides were envisioned as conformational constraints in antigenic peptides (APs). Three different β-lactam tripeptides of varying flexibility were prepared in solution and incorporated in place of the central part of the altered melanoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd15c3a39177740483f28168b9b8609
https://pubmed.ncbi.nlm.nih.gov/20927455
https://pubmed.ncbi.nlm.nih.gov/20927455
Autor:
Emma C. Skoog, Michael A. McGuckin, Yong H. Sheng, Philip Sutton, Sara K. Lindén, Timothy H. Florin, Alison L. Every, Kim M. Miles
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 5, Iss 10, p e1000617 (2009)
PLoS Pathogens, Vol 5, Iss 10, p e1000617 (2009)
The bacterium Helicobacter pylori can cause peptic ulcer disease, gastric adenocarcinoma and MALT lymphoma. The cell-surface mucin MUC1 is a large glycoprotein which is highly expressed on the mucosal surface and limits the density of H. pylori in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1642fe91eae7a6534f2d801794fa06b5
https://doi.org/10.1371/journal.ppat.1000617
https://doi.org/10.1371/journal.ppat.1000617
Publikováno v:
Gastroenterology. 134:A-117
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf75b2f75e57679ef93715f852db011c
https://doi.org/10.1016/s0016-5085(08)60546-6
https://doi.org/10.1016/s0016-5085(08)60546-6