Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kim L. Zeller"'
Autor:
Patricia Schroeder, Jalaj Arora, Kim L. Zeller, Reto Gadient, Minli Zhang, Jeffrey S. Smith, Nathan Spear, Vijay Chhajlani, Deidre E. Wilkins, Mylinh Do
Publikováno v:
European Journal of Pharmacology. 659:146-154
Recent reports have indicated that patients with schizophrenia have a profound hypo-functionality of glutamatergic signaling pathways. Positive allosteric modulation of mGlu(5) receptor has been postulated to augment NMDA function and thereby allevia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070ccb46b7ab7d2b25c844a5605d6845
https://doi.org/10.1016/j.ejphar.2011.02.003
https://doi.org/10.1016/j.ejphar.2011.02.003
Publikováno v:
Psychopharmacology. 166:408-415
Compounds with a mechanism of action different from benzodiazepines may retain the anxiolytic effects of benzodiazepines with fewer side effects. CRF(1) antagonists have anxiolytic-like effects but may have different discriminative stimulus (DS) effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6078f49935d3a96ee9b97eced692f834
https://doi.org/10.1007/s00213-002-1331-8
https://doi.org/10.1007/s00213-002-1331-8
Autor:
Steven Bai, George L. Trainor, Keith J. Miller, Paul J. Gilligan, John F. McElroy, Todd Clarke, Karen Heman, Liqi He, Joanne Saye, Carol M. Krause, David W. Robertson, Yu-Wen Li, Lawrence W. Fitzgerald, Snjezana Lelas, Paul Hartig, Anne Marshall, Scott J. Grossman, Kathyrn Ward, Kim L. Zeller, Harvey Wong, Stephen P Arneric, Ge Zhang, Robert Zaczek
Publikováno v:
Journal of medicinal chemistry. 52(9)
This report describes the syntheses and structure-activity relationships of 8-(substituted pyridyl)pyrazolo[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF(1)) receptor antagonists. These CRF(1) receptor antagonists may be potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64977ac6b05ebbfbea408945e48534b2
https://pubmed.ncbi.nlm.nih.gov/19361209
https://pubmed.ncbi.nlm.nih.gov/19361209
Autor:
Snjezana, Lelas, Harvey, Wong, Yu-Wen, Li, Karen L, Heman, Kathryn A, Ward, Kim L, Zeller, Kristine K, Sieracki, Joseph L, Polino, Helen E, Godonis, Shelly X, Ren, Xiao-Xin, Yan, Stephen P, Arneric, David W, Robertson, Paul R, Hartig, Scott, Grossman, George L, Trainor, Rebecca A, Taub, Robert, Zaczek, Paul J, Gilligan, John F, McElroy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 309(1)
Corticotropin-releasing factor(1) (CRF(1)) antagonists may be effective in the treatment of anxiety disorders with fewer side effects compared with classic benzodiazepines. The behavioral effects of DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2144377a626b48a085b0afadd07313e6
https://pubmed.ncbi.nlm.nih.gov/14742750
https://pubmed.ncbi.nlm.nih.gov/14742750
Autor:
Liqi He, Kathryn A. Ward, Snjezana Lelas, Paul J. Gilligan, John F. McElroy, Kim L. Zeller, Keith W Jones
Publikováno v:
Psychopharmacology. 165(1)
Rationale. CRF1 antagonists may be effective in the treatment of anxiety disorders while having fewer side effects compared with classical benzodiazepines. Objectives. The effects of a small molecule selective CRF1 antagonist DMP696 on anxiety-like b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933294fab0d01893424931b50acd7d29
https://pubmed.ncbi.nlm.nih.gov/12474122
https://pubmed.ncbi.nlm.nih.gov/12474122
Autor:
Amie Mazzola, Kelly Amy, Kenneth W. Rohrbach, William Keim, Kathryn A. Ward, John F. McElroy, James Cawley, Kim L. Zeller
Publikováno v:
Drug Development Research. 30:257-259
The selective dopamine D3 receptor ligand 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) produced stereotypical sniffing and climbing, increased locomotor activity, and caused 6-hydroxydopamine-lesioned animals to rotate in a contralateral dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090cb4db7ba6aef8db641e35d62e88fe
https://doi.org/10.1002/ddr.430300409
https://doi.org/10.1002/ddr.430300409