Metal-free and MRI visible theranostic lyotropic liquid crystal nitroxide-based nanoparticles

Autor: Benjamin W. Muir, Durga Acharya, S. M. Pereira, Ben J. Boyd, Lynne J. Waddington, Bradford A. Moffat, Xavier Mulet, Hong X. Wang, Danielle F. Kennedy, Nigel Kirby, Tracey M. Hinton, Kim L. Wark, Richard A. Evans, Tri-Hung Nguyen, David W. Wright, Gary F. Egan

Publikováno v: Biomaterials. 33:2723-2733

The development of improved, low toxicity, clinically viable nanomaterials that provide MRI contrast have tremendous potential to form the basis of translatable theranostic agents. Herein we describe a class of MRI visible materials based on lyotropi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7dde142ae5b23ff499f9cb681f5f4a
https://doi.org/10.1016/j.biomaterials.2011.12.018

Germline humanization of a murine Aβ antibody and crystal structure of the humanized recombinant Fab fragment

Autor: Janet Newman, Kim L. Wark, Lesley A. Pearce, Olan Dolezal, Remy Robert, Victor A. Streltsov

Publikováno v: Protein Science. 19:299-308

Alzheimer's disease is the most common form of dementia, affecting 26 million people worldwide. The Abeta peptide (39-43 amino acids) derived from the proteolytic cleavage of the amyloid precursor protein is one of the main constituents of amyloid pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260238bfbba489ea91ce496fc07132d2
https://doi.org/10.1002/pro.312

Peptide-Functionalized, Low-Biofouling Click Multilayers for Promoting Cell Adhesion and Growth

Autor: Georgina K. Such, Frank Caruso, Kim L. Wark, Cameron R. Kinnane, Angus P. R. Johnston

Publikováno v: Small. 5:444-448

The preparation of low-fouling poly(ethylene glycol) (PEG) acrylate multilayers through the click-layer-by-layer (LbL) technique was reported. Radical polymerization was used to synthesize PEG-acrylate polymers with alkyne or azide functionalities. N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3e150623f6b359462820777814e76a
https://doi.org/10.1002/smll.200801012

Biodistribution of polymer hydrogel capsules for the delivery of therapeutics

Autor: Kerry Breheney, Kim L. Wark, Mark Tizard, Joseph A. Nicolazzo, Tracey M. Hinton, Sander A.A. Kooijmans, Diane Green, Shuning Shi, Alexander N. Zelikin, Paul Monaghan

Publikováno v: Hinton, T M, Monaghan, P, Green, D, Kooijmans, S A A, Shi, S, Breheney, K, Tizard, M, Nicolazzo, J A, Zelikin, A N & Wark, K 2012, ' Biodistribution of polymer hydrogel capsules for the delivery of therapeutics ', Acta Biomaterialia, vol. 8, no. 9, pp. 3251-60 . https://doi.org/10.1016/j.actbio.2012.05.028

A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc40c02f91c9b229fae5f0e717004e57
https://pubmed.ncbi.nlm.nih.gov/22659177

Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

Autor: Francesca Ercole, Pascal D. Odermatt, Kim L. Wark, Brigitte Städler, Elli Saveriades, Frank Caruso, Rona Chandrawati, Kerry Breheney, Almar Postma, Leticia Hosta-Rigau

Publikováno v: Hosta-Rigau, L, Chandrawati, R, Saveriades, E, Odermatt, P D, Postma, A, Ercole, F, Breheney, K, Wark, K L, Stadler, B & Caruso, F 2010, ' Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery ', Biomacromolecules, vol. 11, pp. 3548-3555 .

We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to nonco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db6a88ae18fe195e4d64e4e1b232556
https://pure.au.dk/portal/da/publications/noncovalent-liposome-linkage-and-miniaturization-of-capsosomes-for-drug-delivery(4d7c7ec0-f962-11df-a891-000ea68e967b).html