Výsledky vyhledávání - "Kim L. Stocking"

Comparison of Submental Blood Collection with the Retroorbital and Submandibular Methods in Mice (Mus musculus)

Autor: Rainy D, Regan, Judy E, Fenyk-Melody, Sam M, Tran, Guang, Chen, Kim L, Stocking

Nonterminal blood sample collection of sufficient volume and quality for research is complicated in mice due to their small size and anatomy. Large (>100 μL) nonterminal volumes of unhemolyzed or unclotted blood currently are typically collected fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3844a64bb5c4256606c43c36a2207653
https://europepmc.org/articles/PMC5029828/

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Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain

Autor: David J. Pinsky, M. Johan Broekman, Jacques J. Peschon, Kim L. Stocking, Tomoyuki Fujita, Ravichandran Ramasamy, E. Sander Connolly, Judy Huang, Szilard Kiss, Yuan Zhang, Tanvir F. Choudhri, Ryan A. McTaggart, Hui Liao, Joan H.F. Drosopoulos, Virginia L. Price, Aaron J. Marcus, Charles R. Maliszewski

Publikováno v: Journal of Clinical Investigation. 109:1031-1040

Endothelial CD39 metabolizes ADP released from activated platelets. Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in response to ADP and reduced cerebral infarct volumes in mice following transient middle ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae326f9d788ff85fee3a6fd95d6d0320
https://doi.org/10.1172/jci0210649

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Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

Autor: Stewart D. Lyman, Jeffrey B. Smith, Charles R. Maliszewski, Hilary J. McKenna, David H. Lynch, Eileen R. Roux, Kim L. Stocking, Bali Pulendran, Kenneth Brasel, Thibaut De Smedt, Mark Teepe, Robert E. Miller, Eugene Maraskovsky, Jacques J. Peschon

Publikováno v: Blood. 95:3489-3497

The ligand for the receptor tyrosine kinase fms-like tyrosine kinase 3 (flt3), also referred to as fetal liver kinase-2 (flk-2), has an important role in hematopoiesis. The flt3 ligand (flt3L) is a growth factor for hematopoietic progenitors and indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee01f985d2c97cb22ec71150fe089c8
https://doi.org/10.1182/blood.v95.11.3489.011k45_3489_3497

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Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice

Autor: Kim L. Stocking, Sandra N. Brown, Sebastian Joyce, Philip J. Morrissey, Monica E. Embers, Naoto Matsuki, Keith Charrier, Eric A. Butz, Lisa M. Sedger, Kenneth Brasel, Moira Glaccum, Jacques J. Peschon, JoAnn C. L. Schuh, Joanne L. Viney, Mary K. Kennedy, Cynthia R. Willis

Publikováno v: The Journal of Experimental Medicine

C57BL/6 mice genetically deficient in interleukin 15 (IL-15−/− mice) were generated by gene targeting. IL-15−/− mice displayed marked reductions in numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype CD8+ T cells, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94442119fb9637300d5cb06846fc344b
https://doi.org/10.1084/jem.191.5.771

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TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

Autor: Jacques J. Peschon, Dauphine S. Torrance, Kim L. Stocking, Moira B. Glaccum, Carol Otten, Cynthia R. Willis, Keith Charrier, Philip J. Morrissey, Carol B. Ware, Kendall M. Mohler

Publikováno v: The Journal of Immunology. 160:943-952

The pleiotropic activities of the potent proinflammatory cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types. The majority of biologic responses classically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb6f71c8b610a603a86ab4382bb25a68
https://doi.org/10.4049/jimmunol.160.2.943

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Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense

Autor: Fred H. Rodriguez, Ping Zhang, Suzanne T. Kanaly, Steve Nelson, Peter Oliver, Jason Zhang, Keith Charrier, Kim L. Stocking, Judd E. Shellito, Weitao Huang, G. J. Bagby, Jay K. Kolls, Paul Schwarzenberger, Jacques J. Peschon, Peng Ye, Jill R. Schurr

Publikováno v: The Journal of Experimental Medicine

Bacterial pneumonia is an increasing complication of HIV infection and inversely correlates with the CD4+ lymphocyte count. Interleukin (IL)-17 is a cytokine produced principally by CD4+ T cells, which induces granulopoiesis via granulocyte colony-st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1397fc6d681960db93fb451ffe87ee0d
https://pubmed.ncbi.nlm.nih.gov/11514607

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An essential role for ectodomain shedding in mammalian development

Autor: Beverly J. Castner, Pranitha Reddy, Raymond J. Paxton, Roy A. Black, Charles Rauch, David C. Lee, Susan W. Sunnarborg, Kim L. Stocking, Douglas P. Cerretti, Nicole Nelson, Jennifer L. Slack, Rogely W. Boyce, Martin F. Wolfson, Carl J. Kozlosky, William E. Russell, Jeffrey N. Fitzner, Richard S. Johnson, Carl J. March, Jacques J. Peschon

Publikováno v: Science (New York, N.Y.). 282(5392)

The ectodomains of numerous proteins are released from cells by proteolysis to yield soluble intercellular regulators. The responsible protease, tumor necrosis factor-α converting enzyme (TACE), has been identified only in the case when tumor necros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb1f43e04dab2db9cb4e9e8d007756f
https://pubmed.ncbi.nlm.nih.gov/9867633

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

Autor: Joseph D. Buxbaum, Richard S. Johnson, Jennifer L. Slack, Yuxia Luo, Kim L. Stocking, Jacques J. Peschon, Roy A. Black, Douglas P. Cerretti, Kang-Nian Liu, Beverly J. Castner

Publikováno v: The Journal of biological chemistry. 273(43)

The amyloid protein, Abeta, which accumulates in the brains of Alzheimer patients, is derived by proteolysis of the amyloid protein precursor (APP). APP can undergo endoproteolytic processing at three sites, one at the amino terminus of the Abeta dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4972c3b8553c8b6202ad785b1ddc19c2
https://pubmed.ncbi.nlm.nih.gov/9774383

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

Publikováno v: Nature. 385(6618)

Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. Modification of the cell surface in this way can alter the cell's responsiveness to its environment and release potent soluble regulatory factors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2c520878f829ffab92255ffaf0d28d
https://pubmed.ncbi.nlm.nih.gov/9034190

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