Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Kim L. R. Brouwer"'
Autor:
William A. Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D. Guy, Manal F. Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Hepatology Communications, Vol 8, Iss 3 (2024)
Background:. NAFLD is highly prevalent with limited treatment options. Bile acids (BAs) increase in the systemic circulation and liver during NAFLD progression. Changes in plasma membrane localization and zonal distribution of BA transporters can inf
Externí odkaz:
https://doaj.org/article/aac573e3c0734319af4532863a1f9a55
Autor:
Chitra Saran, Dong Fu, Henry Ho, Abigail Klein, John K. Fallon, Paavo Honkakoski, Kim L. R. Brouwer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Hepatic cell lines serve as economical and reproducible alternatives for primary human hepatocytes. However, the utility of hepatic cell lines to examine bile acid homeostasis and cholestatic toxicity is limited due to abnormal expression an
Externí odkaz:
https://doaj.org/article/2e928e8ce9f046e3be3c75900b5eddad
Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The sodium taurocholate cotransporting polypeptide (NTCP; gene name SLC10A1) is the primary hepatic basolateral uptake transporter for conjugated bile acids and the entry receptor for the hepatitis B and D virus (HBV/HDV). Regulation of human NTCP re
Externí odkaz:
https://doaj.org/article/b61567257f57433bbe976e0248d56cad
Publikováno v:
ACS Omega, Vol 6, Iss 10, Pp 6708-6713 (2021)
Externí odkaz:
https://doaj.org/article/50085b0e9dfb429eb97f0b07a4e1c799
Autor:
Jacqueline E. McLaughlin, Rebekah L. Layton, Paul B. Watkins, Robert A. Nicholas, Kim L. R. Brouwer
Publikováno v:
PLoS ONE, Vol 17, Iss 12 (2022)
Postgraduate trainees elevate the academic strength of institutions by conducting research, promoting innovation, securing grant funding, training undergraduate students, and building alliances. Rigorous and systematic program evaluation can help ens
Externí odkaz:
https://doaj.org/article/2d903ac2575942c7b1518c2264ccf2ad
Autor:
Raju Khatri, John K. Fallon, Craig Sykes, Natasha Kulick, Rebecca J. B. Rementer, Taryn A. Miner, Amanda P. Schauer, Angela D. M. Kashuba, Kim A. Boggess, Kim L. R. Brouwer, Philip C. Smith, Craig R. Lee
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Pregnancy-related hormones (PRH) are recognized as important regulators of hepatic cytochrome P450 enzyme expression and function. However, the impact of PRH on the hepatic expression and function of uridine diphosphate glucuronosyltransferases (UGTs
Externí odkaz:
https://doaj.org/article/4cac6828a3614bad9e8e1bd1b1e4fcc3
Autor:
Louise Sundqvist, Henry Ho, Jonna Niskanen, Paavo Honkakoski, Kim L. R. Brouwer, Chitra Saran
Publikováno v:
J Pharmacol Exp Ther
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and a major concern in drug development. Altered bile acid homeostasis via inhibition of the bile salt export pump (BSEP) is one mechanism of DILI. Dasatinib, pazopanib, and
Autor:
Kim L. R. Brouwer, Paavo Honkakoski, Melina M. Malinen, Peter W. Swaan, Tuomo Laitinen, Henry Ho, William A. Murphy, James J. Beaudoin, Noora Sjöstedt
Publikováno v:
Molecular Pharmacology. 100:599-608
Organic solute transporter α/β (OSTα/β) is a bidirectional bile acid transporter localized on the basolateral membrane of hepatic, intestinal, and renal epithelial cells. OSTα/β plays a critical role in intestinal bile acid reabsorption and is
Publikováno v:
Transporters and Drug-Metabolizing Enzymes in Drug Toxicity
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 10, Pp 6708-6713 (2021)
ACS Omega, Vol 6, Iss 10, Pp 6708-6713 (2021)
E-cigarette-related hospitalizations and deaths across the U.S. continue to increase. A high percentage of patients have elevated liver function tests indicative of systemic toxicity. This study was designed to determine the effect of e-cigarette che