Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kim L. Nelson"'
Autor:
Dana Huskens, Marilyn C. Darkes, Gary Bridger, Jennifer H. Cox, Simon P. Fricker, Zefferino Santucci, Renee Mosi, Jean Labrecque, Kim L. Nelson, Renato Skerlj, Stefan R. Idzan, Virginia Anastassova, Dominique Schols, Ketan Patel, Rebecca S.Y. Wong, Gloria Lau
Publikováno v:
Biochemical Pharmacology. 83:472-479
In order to enter and infect human cells HIV must bind to CD4 in addition to either the CXCR4 or the CCR5 chemokine receptor. AMD11070 was the first orally available small molecule antagonist of CXCR4 to enter the clinic. Herein we report the molecul
Autor:
Ling Qin, Rebecca Wong, Virginia Anastassov, Simon P. Fricker, Jennifer H. Cox, Renee Mosi, Stefan R. Idzan, Jean Labrecque, Kim L. Nelson, Ognjen Grujic, Gloria Lau, Marilyn C. Darkes, Zeffy Santucci
Publikováno v:
Biochemical Pharmacology. 72:588-596
The chemokine receptor CXCR4 is widely expressed on different cell types, is involved in leukocyte chemotaxis, and is a co-receptor for HIV. AMD3100 has been shown to be a CXCR4 receptor antagonist, and to block HIV infection of T-tropic, X4-using, v
Autor:
J. Thomas Buckley, Kim L. Nelson
Publikováno v:
Journal of Biological Chemistry. 275:19839-19843
Glycosylphosphatidylinositol-anchored proteins may be concentrated in membrane microdomains (lipid rafts) that are also enriched in cholesterol and sphingolipids. The glycosyl anchor of these proteins is a specific, high affinity receptor for the cha
Autor:
Robert A. Brodsky, Galina L. Mukhina, Kim L. Nelson, Tracy S. Lawrence, Richard J. Jones, J. Thomas Buckley
Publikováno v:
Blood. 93:1749-1756
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disorder caused by a somatic mutation of the PIGA gene. The product of this gene is required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; therefore, the phenotypic
Autor:
Robert A. Brodsky, J. Thomas Buckley, Tracy S. Lawrence, Galina L. Mukhina, Richard J. Jones, Kim L. Nelson
Publikováno v:
Blood. 93:1749-1756
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disorder caused by a somatic mutation of the PIGA gene. The product of this gene is required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; therefore, the phenotypic
Autor:
Melanie Ruzek, Kim L. Nelson, Robert J. Scarborough, Stefan R. Idzan, Gary Bridger, Virginia Anastassov, Kathleen S. Neff, Gloria Lau, Marilyn C. Darkes, Rebecca S.Y. Wong, Jean Labrecque, Zefferino Santucci, Renee Mosi, Veronique Bodart, Ketan Patel, Simon P. Fricker, Ron MacFarland
Publikováno v:
Biochemical pharmacology. 78(8)
CXCR4 is widely expressed in multiple cell types, and is involved in neonatal development, hematopoiesis, and lymphocyte trafficking and homing. Disruption of the CXCL12/CXCR4 interaction has been implicated in stem cell mobilization. Additionally CX
Publikováno v:
Cellular microbiology. 1(1)
Aerolysin is a channel-forming toxin that binds to glycosylphosphatidylinositol (GPI)-anchored proteins, such as Thy-1, on target cells. Here, we show that subnanomolar concentrations of aerolysin trigger apoptosis of T lymphomas. Using inactive aero
Autor:
J. Thomas Buckley, Kim L. Nelson, Robert A. Brodsky, Patricia L. Chiurazzi, Shiyong Li, Michael J. Borowitz, Galina L. Mukhina
Publikováno v:
American journal of clinical pathology. 114(3)
Paroxysmal nocturnal hemoglobinuria (PNH) is caused by a somatic mutation in the gene PIGA, which encodes an enzyme essential for the synthesis of glycosylphosphatidylinositol (GPI) anchors. The PIGA mutation results in absence or marked deficiency o
Autor:
Stephen H. Leppla, Kim L. Nelson, Patrick C. Elwood, J. Thomas Buckley, Rodney K. Tweten, Victoria L. Stevens, Valery M. Gordon
Publikováno v:
The Journal of biological chemistry. 274(38)
The alpha toxin produced by Clostridium septicum is a channel-forming protein that is an important contributor to the virulence of the organism. Chinese hamster ovary (CHO) cells are sensitive to low concentrations of the toxin, indicating that they
Autor:
Rodney K. Tweten, Dzung B. Diep, Bret R. Sellman, Tracy S. Lawrence, Kim L. Nelson, J. Thomas Buckley
Publikováno v:
Molecular microbiology. 31(3)
Summary Aerolysin is a bilobal channel-forming toxin secreted by Aeromonas hydrophila. The alpha toxin produced by Clostridium septicum is homologous to the large lobe of aerolysin. However, it does not contain a region corresponding to the small lob