Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Kim L. Nelson"'
Autor:
W.B. Jakoby
Publikováno v:
Analytical Biochemistry. 223:171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d9bc8f9cbef0e7704ee7c7f5febb95
https://doi.org/10.1006/abio.1994.1568
https://doi.org/10.1006/abio.1994.1568
Autor:
Jakoby, W.B.
Publikováno v:
Analytical Biochemistry; November 15, 1994, Vol. 223 Issue: 1 p171-171, 1p
Autor:
Dana Huskens, Marilyn C. Darkes, Gary Bridger, Jennifer H. Cox, Simon P. Fricker, Zefferino Santucci, Renee Mosi, Jean Labrecque, Kim L. Nelson, Renato Skerlj, Stefan R. Idzan, Virginia Anastassova, Dominique Schols, Ketan Patel, Rebecca S.Y. Wong, Gloria Lau
Publikováno v:
Biochemical Pharmacology. 83:472-479
In order to enter and infect human cells HIV must bind to CD4 in addition to either the CXCR4 or the CCR5 chemokine receptor. AMD11070 was the first orally available small molecule antagonist of CXCR4 to enter the clinic. Herein we report the molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84cfd78fc63d6410dc6820fa5f20b2e
https://doi.org/10.1016/j.bcp.2011.11.020
https://doi.org/10.1016/j.bcp.2011.11.020
Autor:
Ling Qin, Rebecca Wong, Virginia Anastassov, Simon P. Fricker, Jennifer H. Cox, Renee Mosi, Stefan R. Idzan, Jean Labrecque, Kim L. Nelson, Ognjen Grujic, Gloria Lau, Marilyn C. Darkes, Zeffy Santucci
Publikováno v:
Biochemical Pharmacology. 72:588-596
The chemokine receptor CXCR4 is widely expressed on different cell types, is involved in leukocyte chemotaxis, and is a co-receptor for HIV. AMD3100 has been shown to be a CXCR4 receptor antagonist, and to block HIV infection of T-tropic, X4-using, v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b4db60773ba40fdf51387c794b452a
https://doi.org/10.1016/j.bcp.2006.05.010
https://doi.org/10.1016/j.bcp.2006.05.010
Autor:
J. Thomas Buckley, Kim L. Nelson
Publikováno v:
Journal of Biological Chemistry. 275:19839-19843
Glycosylphosphatidylinositol-anchored proteins may be concentrated in membrane microdomains (lipid rafts) that are also enriched in cholesterol and sphingolipids. The glycosyl anchor of these proteins is a specific, high affinity receptor for the cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4d134b5c8d2eabc64e62be55123a91
https://doi.org/10.1074/jbc.m002785200
https://doi.org/10.1074/jbc.m002785200
Autor:
Robert A. Brodsky, Galina L. Mukhina, Kim L. Nelson, Tracy S. Lawrence, Richard J. Jones, J. Thomas Buckley
Publikováno v:
Blood. 93:1749-1756
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disorder caused by a somatic mutation of the PIGA gene. The product of this gene is required for the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; therefore, the phenotypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18ef1aafeb32d8659f02877dc1625674
https://doi.org/10.1182/blood.v93.5.1749.405k09_1749_1756
https://doi.org/10.1182/blood.v93.5.1749.405k09_1749_1756
Autor:
Melanie Ruzek, Kim L. Nelson, Robert J. Scarborough, Stefan R. Idzan, Gary Bridger, Virginia Anastassov, Kathleen S. Neff, Gloria Lau, Marilyn C. Darkes, Rebecca S.Y. Wong, Jean Labrecque, Zefferino Santucci, Renee Mosi, Veronique Bodart, Ketan Patel, Simon P. Fricker, Ron MacFarland
Publikováno v:
Biochemical pharmacology. 78(8)
CXCR4 is widely expressed in multiple cell types, and is involved in neonatal development, hematopoiesis, and lymphocyte trafficking and homing. Disruption of the CXCL12/CXCR4 interaction has been implicated in stem cell mobilization. Additionally CX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359e653672bf19a6ca4eab59df45de4c
https://pubmed.ncbi.nlm.nih.gov/19540208
https://pubmed.ncbi.nlm.nih.gov/19540208
Publikováno v:
Cellular microbiology. 1(1)
Aerolysin is a channel-forming toxin that binds to glycosylphosphatidylinositol (GPI)-anchored proteins, such as Thy-1, on target cells. Here, we show that subnanomolar concentrations of aerolysin trigger apoptosis of T lymphomas. Using inactive aero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610a44a42e22677780e5cc188442ccd3
https://pubmed.ncbi.nlm.nih.gov/11207542
https://pubmed.ncbi.nlm.nih.gov/11207542
Autor:
J. Thomas Buckley, Kim L. Nelson, Robert A. Brodsky, Patricia L. Chiurazzi, Shiyong Li, Michael J. Borowitz, Galina L. Mukhina
Publikováno v:
American journal of clinical pathology. 114(3)
Paroxysmal nocturnal hemoglobinuria (PNH) is caused by a somatic mutation in the gene PIGA, which encodes an enzyme essential for the synthesis of glycosylphosphatidylinositol (GPI) anchors. The PIGA mutation results in absence or marked deficiency o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e552c93a243cef4c0c96ccde8a2d355
https://pubmed.ncbi.nlm.nih.gov/10989647
https://pubmed.ncbi.nlm.nih.gov/10989647
Autor:
Stephen H. Leppla, Kim L. Nelson, Patrick C. Elwood, J. Thomas Buckley, Rodney K. Tweten, Victoria L. Stevens, Valery M. Gordon
Publikováno v:
The Journal of biological chemistry. 274(38)
The alpha toxin produced by Clostridium septicum is a channel-forming protein that is an important contributor to the virulence of the organism. Chinese hamster ovary (CHO) cells are sensitive to low concentrations of the toxin, indicating that they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e38a18d67b12dd3b47d377d9de12840
https://pubmed.ncbi.nlm.nih.gov/10480947
https://pubmed.ncbi.nlm.nih.gov/10480947