Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kim L. Mercer"'
Autor:
Rupesh S. Patel, Rodrigo Romero, Emma V. Watson, Anthony C. Liang, Megan Burger, Peter M. K. Westcott, Kim L. Mercer, Roderick T. Bronson, Eric C. Wooten, Arjun Bhutkar, Tyler Jacks, Stephen J. Elledge
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GATA-binding protein 4 (GATA4) is reported to control cell proliferation in cancers. Here the authors show that GATA4’s pro-inflammatory secretome promotes the recruitment of immune cells such as CD8 + T cells to suppress tumour initiation and grow
Externí odkaz:
https://doaj.org/article/0f7b65b8712445b997f900c25649c681
Autor:
Zackery A. Ely, Nicolas Mathey-Andrews, Santiago Naranjo, Samuel I. Gould, Kim L. Mercer, Gregory A. Newby, Christina M. Cabana, William M. Rideout, Grissel Cervantes Jaramillo, Jennifer M. Khirallah, Katie Holland, Peyton B. Randolph, William A. Freed-Pastor, Jessie R. Davis, Zachary Kulstad, Peter M. K. Westcott, Lin Lin, Andrew V. Anzalone, Brendan L. Horton, Nimisha B. Pattada, Sean-Luc Shanahan, Zhongfeng Ye, Stefani Spranger, Qiaobing Xu, Francisco J. Sánchez-Rivera, David R. Liu, Tyler Jacks
Publikováno v:
Nature Biotechnology.
Autor:
Caterina I. Colón, Mary Clare Beytagh, Alexander Muir, Francisco J. Sánchez-Rivera, Santiago Naranjo, Kim L. Mercer, Tania J. González Robles, Matthew G. Vander Heiden, Peter M. K. Westcott, Swanny Lamboy Rodríguez, Sheng Rong Ng, Tyler Jacks, Roderick T. Bronson, Caroline A. Lewis, Laura Z. Liao, Arjun Bhutkar, Peggy P. Hsu, Rodrigo Romero, Leanne Li
Publikováno v:
Nat Cancer
Approximately 20-30% of human lung adenocarcinomas (LUAD) harbor loss-of-function (LOF) mutations in Kelch-like ECH Associated-Protein 1 (KEAP1), which lead to hyperactivation of the nuclear factor, erythroid 2-like 2 (NRF2) antioxidant pathway and c
Autor:
Kim L. Mercer, Jason M. Schenkel, Roderick T. Bronson, Elliot H. Akama-Garren, Tyler Jacks, Arjun Bhutkar, Sheng Rong Ng, William M. Rideout
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SCLC is a deadly disease for which treatment outcomes have not improved significantly for over 30 y due to the lack of effective new therapies. Large-scale sequencing studies have identified many recurrently mutated genes in human SCLC t
Autor:
Jason M. Schenkel, Prajan Divakar, Alex M. Jaeger, Ana P. Garcia, Peter M. K. Westcott, Tyler Hether, Zackery A. Ely, Roderick T. Bronson, Laurens J. Lambert, Jason Reeves, William A. Freed-Pastor, Devan Phillips, Vikram Deshpande, Arjun Bhutkar, Kim L. Mercer, Ömer H. Yilmaz, Tyler Jacks, George Eng, Lin Lin, William L. Hwang, Nimisha B. Pattada, Aviv Regev, Toni Delorey, William M. Rideout
Publikováno v:
Cancer Cell
Summary The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53f9987c16263228fdea161ccfed14
https://europepmc.org/articles/PMC8511341/
https://europepmc.org/articles/PMC8511341/
Autor:
Rupesh S. Patel, Rodrigo Romero, Emma V. Watson, Anthony C. Liang, Megan Burger, Peter M. K. Westcott, Kim L. Mercer, Roderick T. Bronson, Eric C. Wooten, Arjun Bhutkar, Tyler Jacks, Stephen J. Elledge
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The GATA4 transcription factor acts as a master regulator of development of multiple tissues. GATA4 also acts in a distinct capacity to control a stress-inducible pro-inflammatory secretory program that is associated with senescence, a potent tumor s
Autor:
Aviv Regev, Vikram Deshpande, Nimisha B. Pattada, William L. Hwang, Roderick T. Bronson, Jason M. Schenkel, William M. Rideout, Zackery A. Ely, Kim L. Mercer, William A. Freed-Pastor, Toni Delorey, Ana P. Garcia, Peter M. K. Westcott, Tyler Jacks, Laurens J. Lambert, George Eng, Arjun Bhutkar, Devan Phillips, Ömer H. Yilmaz, Lin Lin
Publikováno v:
SSRN Electronic Journal.
The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessful to da
Autor:
Leanne Li, Kim L. Mercer, Rodrigo Romero, Caterina I. Colón, Caroline A. Lewis, Mary Clare Beytagh, Matthew G. Vander Heiden, Arjun Bhutkar, Sheng Rong Ng, Anna F. Farago, David T. Myers, Zhaoqi Li, Mandar Deepak Muzumdar, Christopher S. Nabel, Tyler Jacks, Sarah Phat, Peter M. K. Westcott, Benjamin J. Drapkin, Peggy P. Hsu, Nicholas J. Dyson
Publikováno v:
Sci Transl Med
Small cell lung cancer (SCLC) is an aggressive lung cancer subtype with extremely poor prognosis. No targetable genetic driver events have been identified, and the treatment landscape for this disease has remained nearly unchanged for over 30 years.
Autor:
Nimisha B. Pattada, Laurens J. Lambert, Tyler Jacks, Alex M. Jaeger, George Eng, Kim L. Mercer, Zackery A. Ely, William A. Freed-Pastor, William L. Hwang, Arjun Bhutkar
Publikováno v:
Cancer Research. 81:PO-063
The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. While insights regarding mechanisms of immune escape have fueled tremendous clinical successes in a broad range of tumor types, microsatellite-stable p
Autor:
Megan L. Burger, Roderick T. Bronson, Tyler Jacks, Rodrigo Romero, Rupesh S. Patel, Kim L. Mercer, Emma V. Watson, Peter M. K. Westcott, Eric C. Wooten, Arjun Bhutkar, Anthony C. Liang, Stephen J. Elledge
Publikováno v:
Cancer Immunology Research. 9:IA17-IA17
Cellular senescence is a stress-activated differentiation pathway that causes proliferation arrest governed by two powerful tumor suppressor pathways, USP28-TP53-CDKN1A and CDKN2A-RB. Senescent cells exhibit a pro-inflammatory secretory program terme