Zobrazeno 1 - 10
of 20 965
pro vyhledávání: '"Kim L."'
Autor:
Kim L. de Luca, Pim M. J. Rullens, Magdalena A. Karpinska, Sandra S. de Vries, Agnieszka Gacek-Matthews, Lőrinc S. Pongor, Gaëlle Legube, Joanna W. Jachowicz, A. Marieke Oudelaar, Jop Kind
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Accurate repair of DNA damage is critical for maintenance of genomic integrity and cellular viability. Because damage occurs non-uniformly across the genome, single-cell resolution is required for proper interrogation, but sensitive detectio
Externí odkaz:
https://doaj.org/article/4a8adea22a094f2e87579c732274e6d0
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 9, Pp 1513-1527 (2024)
Abstract OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for drug–drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been reported following multiple‐dose rifampicin; one explanati
Externí odkaz:
https://doaj.org/article/5334c41546ee4ed98d6b56aaabccd6a8
Autor:
Shiyi Julia Zhu, Rachel K. Nelligan, Rana S. Hinman, Alexander J. Kimp, Peixuan Li, Anurika De Silva, Jenny Harrison, Kim L. Bennell
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 4, Pp 100536- (2024)
Background: Knee osteoarthritis (OA) is a leading contributor to global disability, with exercise proven to be an effective treatment. Tai Chi is a recommended type of exercise, but it is primarily done in person which imposes an accessibility issue.
Externí odkaz:
https://doaj.org/article/af1d0b720ded495c99d1ebbe54519120
Autor:
Nicola L. Brice, Mark Carlton, David H. Margolin, Martin Bexon, Kim L. Matthews, Lee A. Dawson, Aaron L. Ellenbogen, C. Warren Olanow, Jordan Dubow, Karl Kieburtz
Publikováno v:
EClinicalMedicine, Vol 77, Iss , Pp 102882- (2024)
Summary: Background: CVN424 is a GPR6 inverse agonist that provides selective pharmacological control of the indirect striatopallidal pathway. We assessed the safety and efficacy of CVN424 as an adjunctive treatment to levodopa for reducing OFF-time
Externí odkaz:
https://doaj.org/article/03ffbbb6c9d240da9bd6c36037040312
Autor:
Brandon C. Rosen, Kaitlin Sawatzki, Michael J. Ricciardi, Elise Smith, Inah Golez, Jack T. Mauter, Núria Pedreño-López, Aaron Yrizarry-Medina, Kim L. Weisgrau, Logan J. Vosler, Thomas B. Voigt, Johan J. Louw, Jennifer Tisoncik-Go, Leanne S. Whitmore, Christakis Panayiotou, Noor Ghosh, Jessica R. Furlott, Christopher L. Parks, Ronald C. Desrosiers, Jeffrey D. Lifson, Eva G. Rakasz, David I. Watkins, Michael Gale
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSpontaneous control of chronic-phase HIV/SIV viremia is often associated with the expression of specific MHC class I allotypes. HIV/SIV-specific CD8+ cytotoxic T lymphocytes (CTLs) restricted by these MHC class I allotypes appear to be cr
Externí odkaz:
https://doaj.org/article/a278c58415384153962a8239ac4c5dc6
Autor:
Kira Mascho, Svetlana A. Yatsenko, Cecilia W. Lo, Xinxiu Xu, Jennifer Johnson, Lindsey R. Helvaty, Stephanie Burns Wechsler, Chaya N. Murali, Seema R. Lalani, Vidu Garg, Jennelle C. Hodge, Kim L. McBride, Stephanie M. Ware, Jiuann-Huey Ivy Lin
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction5p deletion syndrome, also called Cri-du-chat syndrome 5p is a rare genetic syndrome with reports up to 36% of patients are associated with congenital heart defects. We investigated the association between left outflow tract obstruction a
Externí odkaz:
https://doaj.org/article/2ea28b86dde34d79982956d3247450a9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chimeric antigen receptor (CAR) T cell therapy has become an important treatment for hematological cancers, and its success has spurred research into CAR T cell therapies for other diseases, including solid tumor cancers and autoimmune diseases. Nota
Externí odkaz:
https://doaj.org/article/017f6d0038bb4ce7b525fc2fead81864
Publikováno v:
Composites Part C: Open Access, Vol 15, Iss , Pp 100520- (2024)
This study explores the potential of mussel shells (MS) as biogenic fillers in polymer composites. The chemical composition and crystal structures of MS were characterised. To improve MS filler dispersion and adhesion within a polypropylene (PP) matr
Externí odkaz:
https://doaj.org/article/50ea2c4b68fe416ab903c75d5ac26373
Autor:
Maximilian A. Selbst, Colin R. Ward, Megan L. Svetgoff, Hector I. Michelena, Anna Sabate-Rotes, Julie De Backer, Laura Muiño Mosquera, Anji T. Yetman, Malenka M. Bissell, Maria Grazia Andreassi, Ilenia Foffa, Dawn S. Hui, Anthony Caffarelli, Yuli Y. Kim, Dongchuan Guo, Rodolfo Citro, Margot De Marco, Justin T. Tretter, Shaine A. Morris, Kim L. McBride, Simon C. Body, Siddharth K. Prakash
Publikováno v:
Hearts, Vol 5, Iss 3, Pp 253-258 (2024)
Bicuspid aortic valve (BAV) is the most common congenital heart malformation in adults, but it can also cause childhood-onset complications. The presentation and clinical course of young adults who present due to BAV complications are relatively unch
Externí odkaz:
https://doaj.org/article/5648bbbc963b4790a6094237ffd36854
Autor:
Kim L. McIntyre, Shafagh A. Waters, Ling Zhong, Gene Hart-Smith, Mark Raftery, Zahra A. Chew, Hardip R. Patel, Jennifer A. Marshall Graves, Paul D. Waters
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica),
Externí odkaz:
https://doaj.org/article/060615f1445d423c8851ce816efb87ee