Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Kim L Powell"'
Autor:
Pablo M Casillas-Espinosa, Kim L Powell, Mingfu Zhu, C Ryan Campbell, Jessica M Maia, Zhong Ren, Nigel C Jones, Terence J O'Brien, Slavé Petrovski
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179924 (2017)
The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are an inbreed Wistar rat strain widely used as a model of genetic generalised epilepsy with absence seizures. As in humans, the genetic architecture that results in genetic generalized epilep
Externí odkaz:
https://doaj.org/article/46dee321720a45469b20cc15e9c8f2a9
Autor:
Pablo Miguel Casillas-Espinosa, Ashleigh Hicks, Amy Jeffreys, Terrance P Snutch, Terence J O'Brien, Kim L Powell
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0130012 (2015)
Temporal lobe epilepsy (TLE) is the most common form of drug resistant epilepsy. Current treatment is symptomatic, suppressing seizures, but has no disease modifying effect on epileptogenesis. We examined the effects of Z944, a potent T-type calcium
Externí odkaz:
https://doaj.org/article/c8af601b6b674c3a876036627b8c3e8a
Autor:
Johanna Elms, Kim L Powell, Leena van Raay, Stefanie Dedeurwaerdere, Terence J O'Brien, Margaret J Morris
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73505 (2013)
The mechanisms by which valproate, one of the most widely prescribed anti-epileptic drugs, suppresses seizures have not been fully elucidated but may involve up-regulation of neuropeptide Y (NPY). We investigated the effects of valproate treatment in
Externí odkaz:
https://doaj.org/article/c6ed8113ba8443219612d84180a580e2
Autor:
Pablo M. Casillas-Espinosa, Runxuan Lin, Rui Li, Nanditha M. Nandakumar, Georgia Dawson, Emma L. Braine, Benoît Martin, Kim L. Powell, Terence J. O'Brien
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106217- (2023)
Rationale: Low-voltage-activated or T-type Ca2+ channels play a key role in the generation of seizures in absence epilepsy. We have described a homozygous, gain of function substitution mutation (R1584P) in the CaV3.2 T-type Ca2+ channel gene (Cacna1
Externí odkaz:
https://doaj.org/article/b0a167a094254b4caaf3662017799fba
Autor:
Kim L. Powell, Zining Liu, Claire L. Curl, Antonia J.A. Raaijmakers, Pragati Sharma, Emma L. Braine, Flavia M. Gomes, Shobi Sivathamboo, Vaughan G. Macefield, Pablo M. Casillas-Espinosa, Nigel C. Jones, Lea M. Delbridge, Terence J. O’Brien
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105505- (2021)
Objective: This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic acquired temporal lobe epilepsy (TLE), specifically to examine for changes between th
Externí odkaz:
https://doaj.org/article/2f278a222be74d4a903bacd65e7a477e
Autor:
Kim L. Powell, Xavier Fitzgerald, Claire Shallue, Valentina Jovanovska, Matthias Klugmann, Georg Von Jonquieres, Terence J. O'Brien, Margaret J. Morris
Publikováno v:
Neurobiology of Disease, Vol 113, Iss , Pp 23-32 (2018)
Neuropeptide Y (NPY) is an important 36 amino acid peptide that is abundantly expressed in the mammalian CNS and is known to be an endogenous modulator of seizure activity, including in rat models of Genetic Generalised Epilepsy (GGE) with absence se
Externí odkaz:
https://doaj.org/article/6b6f58fc2d804e83905ae1080be7ef5e
Autor:
Pragati Sharma, David K. Wright, Leigh A. Johnston, Kim L. Powell, Mary E. Wlodek, Sandy R. Shultz, Terence J. O'Brien, Krista L. Gilby
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 33-40 (2017)
Alterations in white matter integrity have been well documented in chronic epilepsy and during epileptogenesis. However, the relationship between white matter integrity and a predisposition towards epileptogenesis has been understudied. The FAST rat
Externí odkaz:
https://doaj.org/article/77ba12423dd142f38dc5193a259148fa
Autor:
Rahel Feleke, Dana Jazayeri, Maya Abouzeid, Kim L Powell, Prashant K Srivastava, Terence J O’Brien, Nigel C Jones, Michael R Johnson
Publikováno v:
Brain : a journal of neurology. 145(11)
Prenatal exposure to the anti-seizure medication sodium valproate (VPA) is associated with an increased risk of adverse postnatal neurodevelopmental outcomes, including lowered intellectual ability, autism spectrum disorder and attention-deficit hype
Autor:
Marco Annandale, Yohanes Nursalim, Van Eyk Je, X. Li, Shiang Y. Lim, Chan Ej, Kim L. Powell, Parisa Koutsifeli, Robert G. Parton, Rajesh Katare, Claire L. Curl, Xueyan Hu, Rui-Ping Xiao, Aaron E. Robinson, Enzo R. Porrello, L.M.D. Delbridge, Koen Raedschelders, Terence J. O'Brien, James E. Hudson, L. J. Daniels, Antonia J.A. Raaijmakers, Johannes V Janssens, U. Varma, Rebecca H. Ritchie, Richard J. Mills, Vicky L. Benson, Roberta A. Gottlieb, Wendy T K Ip, Bell, David J. R. Taylor, Kimberley M. Mellor, Aleksandr Stotland, Chanchal Chandramouli, Regis R. Lamberts, Gabriel B. Bernasochi
SummaryDiabetic heart disease is highly prevalent and characterized by diastolic dysfunction. The mechanisms of diabetic heart disease are poorly understood and no targeted therapies are available. Here we show that the diabetic myocardium (type 1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aee16cd88e4ec16dbf778c4ede38ae6a
https://doi.org/10.1101/2021.06.21.449174
https://doi.org/10.1101/2021.06.21.449174
Autor:
Bridgette D. Semple, Wai Lam Leung, Kim L. Powell, Piero Perucca, Pablo M. Casillas-Espinosa, Pragati Sharma, Terence J. O'Brien
Publikováno v:
Epilepsia. 60:2023-2036
Epidemiological data and gene association studies suggest a genetic predisposition to developing epilepsy after an acquired brain insult, such as traumatic brain injury. An improved understanding of genetic determinants of vulnerability is imperative