Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kim L Keen"'
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty. To understand the neu
Externí odkaz:
https://doaj.org/article/0bd6727deed5444eab3e76daa70983fe
Autor:
Kim L. Keen, Andrew J. Petersen, Serkan Erdin, Jaeweon Shin, Robert A. Pearce, Anita Bhattacharyya, Alexander G Figueroa, Benjamin I. Fordyce, Michael E. Talkowski, Ei Terasawa, Rachita Yadav
Publikováno v:
Endocrinology
Gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus play a key role in the regulation of reproductive function. In this study, we sought an efficient method for generating GnRH neurons from human embryonic and induced pluripotent stem c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2cbaf545dc7e1f8f20ac04d90346e9
https://doi.org/10.1210/endocr/bqab120
https://doi.org/10.1210/endocr/bqab120
Autor:
Robert A. Shapiro, Daniel J. Uhlrich, Emily P. Greinwald, Kim L. Keen, David H. Abbott, Ei Terasawa, Matthew T. Flowers, Molly M Willging, Jon E. Levine, Jesi A. Felton
Publikováno v:
Journal of the Endocrine Society
Diminished estradiol (E2) negative feedback action by neuronal ESR1 in the arcuate nucleus (ARC) of the mediobasal hypothalamus (MBH) is hypothesized to cause gonadotropin-releasing hormone (GnRH) hypersecretion, and thus LH excess, contributing to o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c558686aa467ecd96dc39d69892c4ad
http://europepmc.org/articles/PMC7207541
http://europepmc.org/articles/PMC7207541
Publikováno v:
Proceedings of the National Academy of Sciences. 114:13804-13809
Negative and positive feedback effects of ovarian 17β-estradiol (E2) regulating release of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) are pivotal events in female reproductive function. While ovarian feedback on hypothalamo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0fd16b41e69537d3df111746734cd5
https://doi.org/10.1073/pnas.1716097115
https://doi.org/10.1073/pnas.1716097115
Publikováno v:
Seminars in reproductive medicine. 37(2)
To understand the roles of kisspeptin and neurokinin B (NKB) in puberty and sex differences in their involvement, we conducted a series of experiments measuring the release of gonadotropin-releasing hormone (GnRH) and kisspeptin in the median eminenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3d33b729ef77202244c17e6bb0de30
https://pubmed.ncbi.nlm.nih.gov/31847024
https://pubmed.ncbi.nlm.nih.gov/31847024
Publikováno v:
Endocrinology. 157:3588-3603
Reproduction depends on the establishment and maintenance of elevated GnRH neurosecretion. The elevation of primate GnRH release is accompanied by epigenetic changes. Specifically, cytosine residues within the GnRH gene promoter are actively demethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1893ad325de52635a781170edd748287
https://doi.org/10.1210/en.2016-1087
https://doi.org/10.1210/en.2016-1087
Publikováno v:
Endocrinology. 157:70-76
In primates, despite the fact that GnRH neurons are mature at birth, a gonadal steroid independent central inhibition restrains the initiation of puberty. The neural substrates responsible for this central inhibition, however, are unclear. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8800372c442060e4fb39b25c381aedbc
https://doi.org/10.1210/en.2015-1770
https://doi.org/10.1210/en.2015-1770
Autor:
Emily P. Greinwald, Molly M Willging, David H. Abbott, Jesi A. Felton, Jon E. Levine, Robert A. Shapiro, Kim L. Keen, Daniel J. Uhlrich, Matthew T. Flowers, Ei Terasawa
Publikováno v:
Fertility and Sterility. 114:e399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67e2ae0cd82459411788bc91904d599
https://doi.org/10.1016/j.fertnstert.2020.08.1171
https://doi.org/10.1016/j.fertnstert.2020.08.1171
Publikováno v:
Endocrinology. 159(8)
Despite the well-established concept that an increase in pulsatile GnRH release triggers puberty, the precise signaling mechanism responsible for the pubertal increase in GnRH release remains unclear. A recent study indicates that developmental chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d03da07132ba5fe83bfd624444d65b
https://pubmed.ncbi.nlm.nih.gov/29982393
https://pubmed.ncbi.nlm.nih.gov/29982393
Autor:
Ei Terasawa, James P. Garcia, Joseph R. Kurian, Curtis J. Hedman, Brian P. Kenealy, Kim L. Keen
Publikováno v:
Endocrinology. 156:2563-2570
Bisphenol A (BPA) is an industrial compound with pervasive distribution in the environments of industrialized countries. The U.S. Centers for Disease Control recently found that greater than 90% of Americans carry detectable levels of BPA, raising co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4b5e21eb60b72f21f78bcccddc16d6
https://doi.org/10.1210/en.2014-1634
https://doi.org/10.1210/en.2014-1634