Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D

Autor: Ece Canan Sayitoglu, Anna-Maria Georgoudaki, Michael Chrobok, Didem Ozkazanc, Benjamin J. Josey, Muhammad Arif, Kim Kusser, Michelle Hartman, Tamara M. Chinn, Renee Potens, Cevriye Pamukcu, Robin Krueger, Cheng Zhang, Adil Mardinoglu, Evren Alici, Harry Thomas Temple, Tolga Sutlu, Adil Doganay Duru

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments fail to increase overall survival. Natural Killer (NK) cells exert anti-tumor activity upon

Externí odkaz: https://doaj.org/article/7661b8daeda441778d5cd52335100e15

Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity

Autor: Marilyn R. Kehry, Troy D. Randall, Miguel E. Moreno-García, Kim Kusser, David J. Rawlings, Guixiu Shi, Shirly Becker-Herman, Kelly L. Hudkins, Melvin I. Simon, Denny Liggitt, Michael Tighe, Robert Dunn, Ann Marshak-Rothstein, Betty Mousseau, Ravi S. Misra, Charles E. Alpers, Frances E. Lund, Thi Sau Migone, Anil Thankappan

Publikováno v: The Journal of Experimental Medicine

Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gαq subunit of trimeric G proteins (Gnaq−/− mice) have an intrinsic survival advantage over normal B cells, even i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b10f183ff6fa9900d4bf5fd00b4214e
https://doi.org/10.1084/jem.20092735

Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza

Autor: Louise Hartson, Troy D. Randall, Kim Kusser, Javier Rangel-Moreno, Juan Moyron-Quiroz

Publikováno v: Proceedings of the National Academy of Sciences. 104:10577-10582

CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21 (CCL21), and CCL19 are constitutively expressed in secondary lymphoid organs, where they control the placement of lymphocytes and dendritic cells. However, these chemokines are also inducibly e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d5705876c5af3d5cbd16206c6c9a00
https://doi.org/10.1073/pnas.0700591104

Simultaneous Detection of EGFP and Cell Surface Markers by Fluorescence Microscopy in Lymphoid Tissues

Autor: Troy D. Randall, Kim Kusser

Publikováno v: Journal of Histochemistry & Cytochemistry. 51:5-14

Enhanced GFP (EGFP) is a powerful tool for the visualization of tagged proteins and transfected cells and is easily detected by fluorescence microscopy or flow cytometry in living cells. However, soluble EGFP molecules can be lost if cell integrity i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3523d0d0b7147f13595ee5e189cecd3c
https://doi.org/10.1177/002215540305100102

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

Autor: Troy D. Randall, Kim Kusser, William W. Agace, Serge A. van de Pavert, Gera Goverse, Karen Niederreither, Reina E. Mebius, Mark F. R. Vondenhoff, Mascha Greuter, Brenda J. Olivier, Patrick Beke, Rune Blomhoff, Martin Lipp, Uta E. Höpken, Kasia Sitnik, Wouter J. de Jonge

Publikováno v: Nature immunology, 10(11), 1193-1199. Nature Publishing Group
van de Pavert, S A, Olivier, B J, Goverse, G, Vondenhoff, M F R, Greuter, M J, Beke, P, Kusser, K, Hopken, U E, Lipp, M, Niederreither, K, Blomhoff, R, Sitnik, K, Agace, W W, Randall, TD, Jonge, W & Mebius, R E 2009, ' Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation ', Nature Immunology, vol. 10, no. 11, pp. 1193-1U78 . https://doi.org/10.1038/ni.1789
Nature Immunology, 10(11), 1193-1U78. Nature Publishing Group
Nature immunology

The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9af33b53f608c48046e499d872ed3e5
https://pure.amc.nl/en/publications/chemokine-cxcl13-is-essential-for-lymph-node-initiation-and-is-induced-by-retinoic-acid-and-neuronal-stimulation(f96217e1-3767-4eef-a28f-476990955c86).html