Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Kim Kultima"'
Autor:
Madelene Braun, Gustaf Boström, Martin Ingelsson, Lena Kilander, Malin Löwenmark, Dag Nyholm, Joachim Burman, Valter Niemelä, Eva Freyhult, Kim Kultima, Johan Virhammar
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-9 (2023)
Abstract Background Neuroinflammatory processes have been suggested to play a role in the pathophysiology of neurodegenerative diseases and post-hemorrhagic hydrocephalus, but have rarely been investigated in patients with idiopathic normal pressure
Externí odkaz:
https://doaj.org/article/29c63bf757a2417695b586f2ee40f15c
Autor:
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Jennifer C. Howell, William T. Hu, Kim Kultima, Henrietta M. Nielsen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background The APOEε4-promoted risk of Alzheimer’s disease (AD) is lower in Black/African-Americans (B/AAs), compared to non-Hispanic whites (NHWs). Previous studies reported lower plasma apolipoprotein E (apoE) levels in NHW APOEε4-carr
Externí odkaz:
https://doaj.org/article/9d920d8987be435a8cabbddb33f40453
Autor:
Aina Vaivade, Anna Wiberg, Payam Emami Khoonsari, Henrik Carlsson, Stephanie Herman, Asma Al-Grety, Eva Freyhult, Ulla Olsson-Strömberg, Joachim Burman, Kim Kultima
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background The common inflammatory disease multiple sclerosis (MS) is a disease of the central nervous system. For more than 25 years autologous hematopoietic stem cell transplantation (AHSCT) has been used to treat MS. It has been shown to
Externí odkaz:
https://doaj.org/article/510fbe6e321c46e7b1ad0509a8b9084a
Autor:
Shaojing Ye, Nilesh M. Agalave, Fei Ma, Dlovan F. D. Mahmood, Asma Al-Grety, Payam E. Khoonsari, Lin Leng, Camilla I. Svensson, Richard Bucala, Kim Kultima, Pedro L. Vera
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4484 (2024)
Bladder pain is a prominent symptom in Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). We studied spinal mechanisms of bladder pain in mice using a model where repeated activation of intravesical Protease Activated Receptor-4 (PAR4) results in
Externí odkaz:
https://doaj.org/article/5f51cd511ebb4d3eab7edb132833d712
Autor:
Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Kalicharan Patra, Daniel Twohig, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Gøril Rolfseng Grøntvedt, Geir Bråthen, Linda R. White, Kim Kultima, Henrietta M. Nielsen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s disease (AD). Although the increased risk of AD in APOE ε4-carriers is well-established, the
Externí odkaz:
https://doaj.org/article/0b717934524e4c6987e325247b45e8c3
Autor:
Akshai P. Sreenivasan, Philip J Harrison, Wesley Schaal, Damian J. Matuszewski, Kim Kultima, Ola Spjuth
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Comparing chemical structures to infer protein targets and functions is a common approach, but basing comparisons on chemical similarity alone can be misleading. Here we present a methodology for predicting target protein clusters using deep
Externí odkaz:
https://doaj.org/article/5f56d2bafe0f4ce6b58a7083f36a5142
Autor:
Stephanie Herman, Staffan Arvidsson McShane, Christina Zjukovskaja, Payam Emami Khoonsari, Anders Svenningsson, Joachim Burman, Ola Spjuth, Kim Kultima
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106906- (2023)
Summary: Progressive multiple sclerosis (PMS) is currently diagnosed retrospectively. Here, we work toward a set of biomarkers that could assist in early diagnosis of PMS. A selection of cerebrospinal fluid metabolites (n = 15) was shown to different
Externí odkaz:
https://doaj.org/article/ac5a24a6e9a145fc90d3ee9d604b0bbc
Autor:
Karl Sjölin, Kim Kultima, Anders Larsson, Eva Freyhult, Christina Zjukovskaja, Kanar Alkass, Joachim Burman
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-8 (2022)
Abstract Glial fibrillary acidic protein (GFAP), myelin basic protein (MBP), neurofilament light chain (NFL), tau and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) are five neuroglial proteins that are used as CSF or blood biomarkers of tissue dama
Externí odkaz:
https://doaj.org/article/ffc787038985489da4241ccd53e17ea3
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Introduction White matter changes (WMC) on brain imaging can be classified as deep white matter hyperintensities (DWMH) or periventricular hyperintensities (PVH) and are frequently seen in patients with idiopathic normal pressure hydrocephal
Externí odkaz:
https://doaj.org/article/4c63fa9b6fcf4d5ab5714e4768ca537a
Autor:
Madelene Braun, Caroline Bjurnemark, Woosung Seo, Eva Freyhult, Dag Nyholm, Valter Niemelä, Kaj Blennow, Henrik Zetterberg, David Fällmar, Kim Kultima, Johan Virhammar
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Lumbar punctures are a common examination in the work-up of patients with idiopathic normal pressure hydrocephalus (iNPH) and cerebrospinal fluid (CSF) biomarkers should therefore be available for use in selection of shunt candida
Externí odkaz:
https://doaj.org/article/806a69f998fe418984bffc91e7adaa6c