Impaired Overall Survival in Young Patients With Acute Myeloid Leukemia and Variants in Genes Predisposing for Myeloid Malignancies

Autor: Martin Kirschner, Benjamin Rolles, Martina Crysandt, Christoph Röllig, Friedrich Stölzel, Michael Kramer, Martin Bornhäuser, Hubert Serve, Uwe Platzbecker, Carsten Müller-Tidow, Kim Kricheldorf, Margherita Vieri, Matthias Begemann, Angela Maurer, Marcin W. Wlodarski, Sushree S. Sahoo, Tim H. Brümmendorf, Edgar Jost, Fabian Beier

Publikováno v: HemaSphere, Vol 6, Iss 11, p e787 (2022)

Externí odkaz: https://doaj.org/article/0e8368a4fdd3492cbeb5fb44412299db

Clinicohematologic and Molecular Response of Essential Thrombocythemia Patients Treated with Pegylated Interferon-Alpha: A Multicenter Study on Behalf of the German Study Group-MPN (GSG-MPN)

Autor: Frank Stegelmann, Lino L. Teichmann, Florian H. Heidel, Carl C. Crodel, Thomas Ernst, Sebastian Kreil, Andreas Reiter, Sara Otten, Stefanie Schauer, Ruth-Miriam Körber, Kim Kricheldorf, Susanne Isfort, Hartmut Döhner, Tim H. Brümmendorf, Martin Griesshammer, Konstanze Döhner, Steffen Koschmieder

Publikováno v: Blood. 140:6874-6876

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b5d0b3cb949a6b24c60f5aa79fd9f9f
https://doi.org/10.1182/blood-2022-165034

Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasms

Autor: Tim H. Brümmendorf, Kim Kricheldorf, Beate Betz, Ulrich Germing, Deniz Gezer, Susanne Isfort, Robert Meyer, Eggermann Thomas, Ingo Kurth, Steffen Koschmieder, Miriam Elbracht, Lino L. Teichmann

Publikováno v: Blood Adv

The molecular causes of myeloproliferative neoplasms (MPNs) have not yet been fully elucidated. Approximately 7% to 8% of the patients carry predisposing genetic germline variants that lead to driver mutations, which enhance JAK-STAT signaling. To id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b78e8ef61b12acdde59b543b9ab2ecc
https://doi.org/10.1182/bloodadvances.2021004811

Germline Variants in MDM4 Cause a Disorder of p53 Dysregulation and Insufficient Telomere Maintenance

Autor: Robert Meyer, Matthias Begemann, Marcus Jakob, Claudia Khurana, Daniela Dey, Tarek Hanafee Alali, Heinz Gabriel, Kim Kricheldorf, Margherita Vieri, Susanne Isfort, Martin Kirschner, Jens Panse, Udo Kontny, Selim Corbacioglu, Tim H. Brümmendorf, Ingo Kurth, Fabian Beier

Publikováno v: Blood. 140:2951-2952

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77dbd8f789d0455873496a87572582c1
https://doi.org/10.1182/blood-2022-168631

Kidney dysfunction is associated with thrombosis and disease severity in myeloproliferative neoplasms: implications from the German Study Group for MPN Bioregistry

Autor: Judith Gecht, Stefani Parmentier, Joachim R. Göthert, Mathias Hänel, Uwe Platzbecker, Tim H. Brümmendorf, Steffen Koschmieder, Christoph Maintz, Richard A. Hansen, Kim Kricheldorf, Martin Kirschner, Fabian Lang, Katja Sockel, Heike L. Pahl, Haifa Kathrin Al-Ali, Ioannis Tsoukakis, Susanne Isfort, Holger Schulz, Norbert Gattermann, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner, Martin Bommer, Martine Klausmann, Florian H Heidel, Wiebke Hollburg

Publikováno v: Cancers 13(16), 4086 (2021). doi:10.3390/cancers13164086 special issue: "Special Issue "Advances in the Pathobiology, Diagnosis and Treatment of Chronic Myeloid Neoplasms" / Special Issue Editors: Dr. Luis Colomo, Guest Editor; Dr. Xavier Calvo, Guest Editor"
Cancers
Volume 13
Issue 16
Cancers, Vol 13, Iss 4086, p 4086 (2021)

Inflammation-induced thrombosis represents a severe complication in patients with myeloproliferative neoplasms (MPN) and in those with kidney dysfunction. Overlapping disease-specific attributes suggest common mechanisms involved in MPN pathogenesis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e59d1837a28a0dea1e297b449541b2
http://publikationen.ub.uni-frankfurt.de/files/62188/container.zip