Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kim Jonelle Stutzman-Engwall"'
Autor:
Alexandros Papanikolaou, Elaine E. Tseng, Noguchi Hirohide, Michael Aaron Brodney, Michelle Vanase-Frawley, Laura McDowell, Nobuaki Waizumi, Katherine Fisher, Aarti Sawant-Basak, Betty Pettersen, Elena M. Drummond, David M. Rubitski, Anne W. Schmidt, Kim Jonelle Stutzman-Engwall, David E. Johnson, Emily L. Hudson, Sarah Grimwood, Karen J. Coffman
Publikováno v:
Journal of Medicinal Chemistry. 55:9240-9254
The cognitive impairments observed in Alzheimer’s disease (AD) are in part a consequence of reduced acetylcholine (ACh) levels resulting from a loss of cholinergic neurons. Preclinically, serotonin 4 receptor (5-HT4) agonists are reported to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d51b0b91e9707931c753f01d83b2c9f
https://doi.org/10.1021/jm300953p
https://doi.org/10.1021/jm300953p
Autor:
Beverly A. Reitz, Thomas L. Emmons, Alfredo G. Tomasselli, H. David Fischer, Michael J. Bienkowski, S. Edward Lee, David Wasilko, Karl J. Mathis, Kim Jonelle Stutzman-Engwall
Publikováno v:
Protein Expression and Purification. 65:122-132
Compounds capable of stimulating soluble guanylate cyclase (sGC) activity might become important new tools to treat hypertension. While rational design of these drugs would be aided by elucidation of the sGC three-dimensional structure and molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d67ccc292e9fe1d6be21cbe94fae775
https://doi.org/10.1016/j.pep.2009.01.002
https://doi.org/10.1016/j.pep.2009.01.002
Autor:
Hamish A. I. McArthur, Ronald Fedechko, Richard John Fox, Steve Conlon, Stephane J. Jenne, Anke Krebber, Kim Seran, Charlene La, Ying-Xin Zhang, Na Trinh, Yan Chen, Kim Jonelle Stutzman-Engwall, Claes Gustafsson, Katja Pekrun
Publikováno v:
Metabolic Engineering. 7:27-37
The avermectin analog doramectin (CHC-B1), sold commercially as Dectomax, is biosynthesized by Streptomyces avermitilis. aveC, a gene encoding an unknown mechanistic function, plays an essential role in the production of doramectin (avermectin CHC-B1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac7808a0edad7b3cc97d48ec44c9a6a
https://doi.org/10.1016/j.ymben.2004.07.003
https://doi.org/10.1016/j.ymben.2004.07.003
Autor:
Aarti Sawant-Basak, Emily Miller, Michelle Vanase-Frawley, Mihály Hajós, Laura McDowell, David M. Rubitski, Kim Jonelle Stutzman-Engwall, Roxanne R Gorczyca, Weldon Horner, Katherine Fisher, Elaine E. Tseng, David E. Johnson, Sarah Grimwood, Elena M. Drummond, Chester J. Siok, Robin T. Nelson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 341(3)
5-Hydroxytryptamine (5-HT)(4) receptor agonists reportedly stimulate brain acetylcholine (ACh) release, a property that might provide a new pharmacological approach for treating cognitive deficits associated with Alzheimer's disease. The purpose of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e004fc131fe86d44da7998100426a1d2
https://pubmed.ncbi.nlm.nih.gov/22408061
https://pubmed.ncbi.nlm.nih.gov/22408061
Publikováno v:
Scopus-Elsevier
The degradation of Streptomyces avermitilis DNA samples analysed by conventional pulsed-field gel electrophoresis was shown to be due to Tris-dependent, double-strand cleavage. Using alternative electrophoretic conditions, separation of intact DNA mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d017022fc6a32b83c62b6e360b9111
https://doi.org/10.1099/00221287-140-6-1367
https://doi.org/10.1099/00221287-140-6-1367
Autor:
Laurie C. Warren, Donghui Xia, Alison H. Varghese, Mark Ammirati, David Cunningham, Kieran F. Geoghegan, Timothy A. Subashi, Dennis E. Danley, Julie Jia Li Hawkins, Mahmoud N. Mansour, Katherine M McGrath, Shirish Shenolikar, Xiayang Qiu, Lise R. Hoth, Matthew C. Griffor, Kim Jonelle Stutzman-Engwall, Andrew P. Seddon, Jeffrey S. Culp
Publikováno v:
Nature structuralmolecular biology. 14(5)
Proprotein convertase subtilisin kexin type 9 (PCSK9) lowers the abundance of surface low-density lipoprotein (LDL) receptor through an undefined mechanism. The structure of human PCSK9 shows the subtilisin-like catalytic site blocked by the prodomai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ebb8fa2c30c4ad0506e21110dad83a
https://pubmed.ncbi.nlm.nih.gov/17435765
https://pubmed.ncbi.nlm.nih.gov/17435765
Autor:
Katherine M McGrath, Timothy A. Subashi, Dennis E. Danley, Ann Subashi, Mark Ammiratti, George A. Karam, Ronald W. Clark, Steven J. Hawrylik, Ing-Kae Wang, Jeffrey S. Culp, Yang Cong, Lise R. Hoth, Kieran F. Geoghegan, Honglei Zhao, Thomas J. McLellan, Xiayang Qiu, Matthew C. Griffor, Thomas B. Freeman, Theresa Dickinson, Anil Mistry, Kim Jonelle Stutzman-Engwall, Boris A. Chrunyk
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8754cd974b61a2508165a58d04428fcb
https://doi.org/10.1096/fasebj.21.6.lb8-b
https://doi.org/10.1096/fasebj.21.6.lb8-b
Autor:
Cheryl Myers Hayward, Matthew C. Griffor, David B. Lloyd, Honglei Zhao, Steven J. Hawrylik, Maruja E. Lira, Boris A. Chrunyk, Andrew P. Seddon, George A. Karam, Kieran F. Geoghegan, Preston Hensley, Anil Mistry, Thomas B. Freeman, Ann Subashi, Kim Jonelle Stutzman-Engwall, Ing-Kae Wang, Ronald W. Clark, Jeffrey S. Culp, Mark Ammirati, Timothy A. Subashi, Dennis E. Danley, John F. Thompson, Xiayang Qiu, Lise R. Hoth, Katherine M McGrath, Yang Cong
Publikováno v:
Nature structuralmolecular biology. 14(2)
Cholesteryl ester transfer protein (CETP) shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species. Inhibition of CE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0f327352a3d62374487890793dec8d
https://pubmed.ncbi.nlm.nih.gov/17277799
https://pubmed.ncbi.nlm.nih.gov/17277799
Autor:
Wei Shou Hu, Claudio D. Denoya, Gargi Seth, Kim Jonelle Stutzman-Engwall, Robin Philp, Katherine M McGrath, Miranda Yap
Publikováno v:
Biotechnology and bioengineering. 90(5)
NS0, a nonsecreting mouse myeloma cell, is a major host line used for recombinant antibody production. These cells have a cholesterol-dependent phenotype and rely on an exogenous supply of cholesterol for their survival and growth. To better understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94997f1d8270bcdfb882290d0e60e86
https://pubmed.ncbi.nlm.nih.gov/15830340
https://pubmed.ncbi.nlm.nih.gov/15830340
Autor:
Barrie Wilkinson, Steven G. Kendrew, Lindsey Low, Rose Mary Sheridan, James Staunton, Rachel E. Lill, Peter F. Leadlay, Alison J. Weston, Ian S. Galloway, Gabriele Wirtz, Sabine Gaisser, Kim Jonelle Stutzman-Engwall, Hamish A. I. McArthur, Andrew L. Kaja, Laurenz Kellenberger
Publikováno v:
Organicbiomolecular chemistry. 1(16)
Ivermectin™, a mixture of 22,23-dihydroavermectin B1a 9 with minor amounts of 22,23-dihydroavermectin B1b 10, is one of the most successful veterinary antiparasitic drugs ever produced. In humans, ivermectin has been used for the treatment of Afric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfad79557051b083e68cf3a1edef2d04
https://pubmed.ncbi.nlm.nih.gov/12968333
https://pubmed.ncbi.nlm.nih.gov/12968333