Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kim G. Madsen"'
Autor:
Jacob Kofoed, Rasmus Jorgensen, Birgitte Schjellerup Wulff, Kim G. Madsen, Johan F. Paulsson, Søren Dinesen Østergaard
Publikováno v:
Journal of Medicinal Chemistry. 61:10519-10530
In recent years peptide YY (PYY) has attracted attention within the area of diabetes and obesity due to its involvement in food intake regulation and glucose homeostasis. It is well-known that PYY1–36 is rapidly cleaved by dipeptidyl peptidase-4 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cd84dac6651c1b1815b41141ba5b1a6
https://doi.org/10.1021/acs.jmedchem.8b01046
https://doi.org/10.1021/acs.jmedchem.8b01046
Autor:
Kim G. Madsen, Flemming L. Søndergaard, Jonas Ahnfelt-Rønne, Andrew J. Benie, Simon Bjerregaard, Jeanett Borregaard, Tine A. Bækdal, Betty Lomstein Pedersen, Susanne Schéele, Charles Pyke, Marie-Louise Hartoft-Nielsen, Stephen T. Buckley, Tomas Alanentalo, Rikke Bjerring Skyggebjerg, Rikke Kaae Kirk, Lotte Bjerre Knudsen, Stine J. Maarbjerg, Holger M. Strauss, Andreas Vegge, Csaba Fekete, Erzsébet Farkas, Per-Olof Wahlund
Publikováno v:
Science Translational Medicine. 10
Oral administration of therapeutic peptides is hindered by poor absorption across the gastrointestinal barrier and extensive degradation by proteolytic enzymes. Here, we investigated the absorption of orally delivered semaglutide, a glucagon-like pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da23aec5d09c52d95e43b0ca9e999cdb
https://doi.org/10.1126/scitranslmed.aar7047
https://doi.org/10.1126/scitranslmed.aar7047
Autor:
Jacobsen Thomas Amos, Martin S. Jørgensen, Patrik Rydberg, Anne-Marie Jacobsen, Kim G. Madsen, Lars Olsen
Publikováno v:
Angewandte Chemie. 125:1027-1031
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9141229c4f9a3b2fe4e9e41eb80f9669
https://doi.org/10.1002/ange.201206207
https://doi.org/10.1002/ange.201206207
Autor:
Steen Honoré Hansen, Kim G. Madsen, Gunnar Grönberg, Ulrik Jurva, Christian Skonberg, Jørgen Olsen
Publikováno v:
Chemical Research in Toxicology. 21:2035-2041
Troglitazone (TGZ) was developed for the treatment of type 2 diabetes but was withdrawn from the market due to hepatotoxicity. The formation of reactive metabolites has been associated with the observed hepatotoxicity. Such reactive metabolites have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971dcd3e968a526c881cfc7b036930df
https://doi.org/10.1021/tx8002214
https://doi.org/10.1021/tx8002214
Autor:
Tommy N. Johansen, Claus Cornett, Steen Honoré Hansen, Christian Skonberg, Ulrik Jurva, Kim G. Madsen, Jørgen Olsen
Publikováno v:
Chemical Research in Toxicology. 21:1107-1119
Diclofenac is widely used in the treatment of, for example, arthritis and muscle pain. The use of diclofenac has been associated with hepatotoxicity, which has been linked to the formation of reactive metabolites. Diclofenac can be metabolized to 4'-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467a5ef575c2de86823c8c3bdbbe3f81
https://doi.org/10.1021/tx700419d
https://doi.org/10.1021/tx700419d
Publikováno v:
Chemical Research in Toxicology. 20:821-831
A reactive metabolite may react covalently with proteins or DNA to form adducts that ultimately may lead to a toxic response. Reactive metabolites can be formed via, for example, cytochrome P450-mediated phase 1 reactions, and in this study, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b379c0c20dddad7c6edc9b2eecf4f57
https://doi.org/10.1021/tx700029u
https://doi.org/10.1021/tx700029u
Autor:
Jesper Bjerrum, Bente Gammelgaard, Ulrik Sidenius, Lars Bendahl, Jørgen Olsen, Ole Jøns, Kim G. Madsen
Publikováno v:
University of Copenhagen
When humans are supplied with selenium-containing nutritional preparations, one of the selenium-containing metabolites in urine increases relatively more than the other selenium metabolites. The purpose of this study was to identify this major seleni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a29d9ec7822bb2edbc5122e6f663a9b
https://doi.org/10.1039/b209832f
https://doi.org/10.1039/b209832f
Autor:
Marco Persico, Kim G. Madsen, Jacobsen Thomas Amos, Giuseppe Campiani, Jørgen Scheel-Krüger, Caterina Fattorusso, Sandra Gemma, Francesco Trotta, Vinod Kumar, Karin Sandager-Nielsen, Isabella Fiorini, Nausicaa Orteca, Stefania Butini, Egeria Guarino, Silvia Franceschini, Giuseppe Borrelli, Ettore Novellino
As a continuation of our efforts to develop innovative ligands for D(3), 5-HT(1A), and 5-HT(2A) receptors with low propensity to block hERG channels, we propose a series bishetero(homo)arylpiperazines 5a-m as novel and potent multifunctional ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f094d43fed01475204cbbff0a468789e
http://hdl.handle.net/11588/374361
http://hdl.handle.net/11588/374361
Publikováno v:
Expert opinion on drug metabolismtoxicology. 4(4)
Carboxylic acids constitute a large and heterogeneous class of both endogenous and xenobiotic compounds. A number of carboxylic acid drugs have been associated with adverse reactions, linked to the metabolic activation of the carboxylic acid moiety o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d896a19f8dc014790bdd67de7b8e06a
https://pubmed.ncbi.nlm.nih.gov/18433345
https://pubmed.ncbi.nlm.nih.gov/18433345
Autor:
Claus Cornett, Kim G. Madsen, Bente Gammelgaard, Kristoffer Lunøe, Helle Ruesz Hansen, Stefan Stürup, Charlotte Gabel-Jensen, Jesper Bendix
Publikováno v:
Journal of Analytical Atomic Spectrometry. 23:727
The metabolism of methylseleninic acid, MeSeA in the gastro-intestinal tract was studied by incubation of MeSeA with homogenized intestinal epithelial cells from pigs. The major selenium-containing metabolite was identified by analysis of the superna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cf0326fd7b0f4cdc6a04ff797ead709
https://doi.org/10.1039/b715899h
https://doi.org/10.1039/b715899h