Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kim E Boonekamp"'
Autor:
Annie S. P. Yang, Devanjali Dutta, Kai Kretzschmar, Delilah Hendriks, Jens Puschhof, Huili Hu, Kim E. Boonekamp, Youri van Waardenburg, Susana M. Chuva de Sousa Lopes, Geert-Jan van Gemert, Johannes H. W. de Wilt, Teun Bousema, Hans Clevers, Robert W. Sauerwein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life-cycle interruption, understanding of parasite-hepa
Externí odkaz:
https://doaj.org/article/5c88670c6cde4830afc419a55a86cad4
Autor:
Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The heterogeneity underlying cancer organoid phenotypes is not yet well understood. Here, the authors develop an imaging analysis assay for high throughput phenotypic screening of colorectal organoids that allows to define specific morphological chan
Externí odkaz:
https://doaj.org/article/781b445e149e41f2a3b65e3af8beee8f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5349 (2023)
Wnt ligands are secreted signaling proteins that display a wide range of biological effects. They play key roles in stimulating Wnt signaling pathways to facilitate processes such as tissue homeostasis and regeneration. Dysregulation of Wnt signaling
Externí odkaz:
https://doaj.org/article/5c927947edb842a2a2450c5f9ac8d606
Autor:
Qiyun Xiao, Johannes Werner, Nachiyappan Venkatachalam, Kim E. Boonekamp, Matthias P. Ebert, Tianzuo Zhan
Publikováno v:
Biomolecules, Vol 12, Iss 3, p 453 (2022)
Targeting cancer hallmarks is a cardinal strategy to improve antineoplastic treatment. However, cross-talk between signaling pathways and key oncogenic processes frequently convey resistance to targeted therapies. The p53 and Wnt pathway play vital r
Externí odkaz:
https://doaj.org/article/e3c412e2b6274ce6864e11f3cc57ef05
Autor:
Johannes Betge, Niklas Rindtorff, Jan Sauer, Benedikt Rauscher, Clara Dingert, Haristi Gaitantzi, Frank Herweck, Kauthar Srour-Mhanna, Thilo Miersch, Erica Valentini, Kim E. Boonekamp, Veronika Hauber, Tobias Gutting, Larissa Frank, Sebastian Belle, Timo Gaiser, Inga Buchholz, Ralf Jesenofsky, Nicolai Härtel, Tianzuo Zhan, Bernd Fischer, Katja Breitkopf-Heinlein, Elke Burgermeister, Matthias P. Ebert, Michael Boutros
Publikováno v:
Nature communications. 13(1)
Patient-derived organoids resemble the biology of tissues and tumors, enabling ex vivo modeling of human diseases. They have heterogeneous morphologies with unclear biological causes and relationship to treatment response. Here, we use high-throughpu
Autor:
Hans Clevers, Barbara Giovannone, Susana M. Chuva de Sousa Lopes, Kai Kretzschmar, Mandy Koomen, Margit Bleijs, Kim E Boonekamp, Priyanca Asra
Publikováno v:
Stem Cell Reports
Stem Cell Reports, 16(9), 2379-2394. CELL PRESS
Stem Cell Reports, 16(9), 2379-2394. Cell Press
Stem Cell Reports, 16(9), 2379-2394. CELL PRESS
Stem Cell Reports, 16(9), 2379-2394. Cell Press
Summary The skin epidermis is a highly compartmentalized tissue consisting of a cornifying epithelium called the interfollicular epidermis (IFE) and associated hair follicles (HFs). Several stem cell populations have been described that mark specific
Publikováno v:
Journal of Molecular Cell Biology
Nature Reviews Molecular Cell Biology, 12(8), 562-568. Nature Publishing Group
Nature Reviews Molecular Cell Biology, 12(8), 562-568. Nature Publishing Group
Autor:
Michiel Vermeulen, Madelon M. Maurice, Lars Ootes, Maureen Spit, Jeroen M. Bugter, Sylvia F. Boj, Tomasz Witold Radaszkiewicz, Jan Paul Medema, Alba Cristobal, Katerina Hanakova, Max van Osch, Eline Janssen, Vitezslav Bryja, Bon-Kyoung Koo, David Potesil, Zbynek Zdrahal, Kim E. Boonekamp, Rik G.H. Lindeboom, Ingrid Jordens, Nicola Fenderico
Publikováno v:
The EMBO Journal
EMBO journal, 39(18):e103932. Wiley-Blackwell
EMBO Journal, 39
EMBO Journal, 39, 18
EMBO journal, 39(18):e103932. Wiley-Blackwell
EMBO Journal, 39
EMBO Journal, 39, 18
Wnt/β‐catenin signaling is a primary pathway for stem cell maintenance during tissue renewal and a frequent target for mutations in cancer. Impaired Wnt receptor endocytosis due to loss of the ubiquitin ligase RNF43 gives rise to Wnt‐hypersensit
Autor:
Kim E Boonekamp, Antoni P. A. Hendrickx, Benedetta Artegiani, Deborah A. Schaefer, Michael W. Riggs, Inha Heo, Devanjali Dutta, Robert J L Willems, Nino Iakobachvili, Roberta M. O'Connor, Gregory D. Bowden, Hans Clevers, Norman Sachs, Peter J. Peters
Publikováno v:
Nature Microbiology, 3(7), 814-823. Nature Publishing Group
Nature Microbiology, 3(7), 814. Nature Publishing Group
Nature Microbiology
Nature Microbiology, 3(7), 814. Nature Publishing Group
Nature Microbiology
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues, representing valuable systems to model medical disorders such as infectious diseases. Cryptosporidium, a protozoan parasite, is a leading cause of diarrhoea and a
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures
Autor:
Dominique J Wiener, Sepideh Derakhshan, Priyanca Asra, Carmen López-Iglesias, Kim E Boonekamp, Hans Clevers, Onur Basak, Jens Puschhof, Kai Kretzschmar, Peter J. Peters
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 116(29), 14630
Proceedings of the National Academy of Sciences of the United States of America, 116(29), 14630-14638. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 116(29), 14630-14638. National Academy of Sciences
Mammalian epidermal stem cells maintain homeostasis of the skin epidermis and contribute to its regeneration throughout adult life. While 2D mouse epidermal stem cell cultures have been established decades ago, a long-term, feeder cell- and serum-fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10159d32ab64404352f707677fc10612
https://dspace.library.uu.nl/handle/1874/392268
https://dspace.library.uu.nl/handle/1874/392268